Aloe Vera Benefits

A centuries-old treatment for burns and other concerns

Aloe vera is a succulent plant that has been used medicinally for centuries. Most commonly known as a remedy for sunburn, aloe vera is useful for rashes, burns, wounds, and other skin conditions. It also helps to improve digestive health and may help regulate blood sugar in people with diabetes.

The aloe vera plant has long, thick triangular leaves and is relatively easy to grow at home. The outer layer is the rind, the middle layer is a bitter yellow sap, and the center is a gel (which can be applied directly to the skin). The plant can also be peeled and juiced; oral supplements are also available.

This article discusses the health benefits of aloe vera and the scientific research behind it. It also discusses potential side effects and harms from aloe vera, who should not use aloe vera, and what to look for when choosing aloe products.

Forms of aloe vera
 Verywell / JR Bee

Dietary supplements are not regulated in the United States, meaning the FDA does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. However, even if supplements are third-party tested, that doesn’t mean they are safe for all or effective in general. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications.

Supplement Facts

  • Active Ingredient(s): Aloe vera
  • Alternate Name(s): Aloe Barbadensis Miller, Burn Plant, Elephant's Gall, Kathalai (Ayurvedic), Lu Hui (traditional Chinese)
  • Legal Status: As of 2002, the FDA banned laxative manufacturers from including aloe in OTC laxative products due to a lack of data submitted by manufacturers supporting its safety. These products can be purchased legally but are now sold as supplements rather than drugs. FDA regulation of supplements is less strict than that for drugs and does not require approval from the FDA before entering the market. Aloe gel and whole leaf extract are also sold under this category. Topical aloe gels are considered cosmetics and do not require pre-market approval from the FDA. The FDA has also approved aloe as a natural flavoring in foods.
  • Suggested Dose: There are no formal recommendations for aloe dosing. When applied to the skin (topically), the quantity will vary significantly based on individual needs. Studies of oral aloe gel capsules for type 2 diabetes and prediabetes frequently use doses of 300 to 500 milligrams twice daily for two to three months.
  • Safety Considerations: Studies in rodents have suggested that aloe latex and whole leaf aloe extract (which includes aloe latex if not decolorized) may promote cancer. Case studies in humans have associated the use of aloe latex with hepatitis (liver inflammation), kidney failure, gastrointestinal upset, and increased risk of bleeding.

Uses of Aloe Vera

Aloe vera has been used to treat many conditions. As you review the science surrounding aloe vera, please remember that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.

Skin Health

People have used aloe vera gel to treat many skin conditions, such as sunburn, thermal burns, and other common skin conditions.

A randomized controlled trial in humans suggested that topical aloe gel reduces markers of inflammation. Laboratory research supports that aloe vera also promotes the creation of new skin cells, protective cells (keratinocytes), and cells that help skin strength (fibroblasts). Additionally, laboratory research has suggested that components of aloe gel act as antioxidants and have antibacterial effects.

However, is there evidence that aloe can significantly impact your health? The available research is often conflicting. Studies of topical aloe vera's effect on wound healing are inconsistent, with some studies showing delays. Although clinical trials specifically assessing aloe vera and thermal burns are supportive that applying aloe can improve recovery.

Even though aloe vera gel is commonly used for sunburn treatment, research on this topic is minimal. Of the few studies available, the majority support that aloe vera gel can increase the speed of recovery from sunburn. Research on pain relief with the topical use of aloe is also scarce, and results are inconsistent. More research on pain relief is needed before conclusions can be drawn.

While some laboratory and animal studies suggest aloe could benefit people living with psoriasis and eczema, high-quality human research is needed. A review article published in the American Journal of Clinical Dermatology found that there was not enough evidence to recommend using aloe vera to treat these conditions. No research on using aloe vera to treat rashes from allergenic plants such as poison oak and ivy is available.

Diabetes & Metabolism

Diabetes mellitus is a condition that results in changes in the body's ability to control blood sugar levels. Type 2 diabetes is a common condition and has a major impact on the health of those living with the condition and is a focus area for new therapies. Research on the effect of aloe vera on diabetes is somewhat mixed and studies are often hard to compare due to the different forms of aloe vera used (such as aloe gel powder, aloe juice, or whole leaf extract).

Researchers created a summary of many studies (i.e., a systematic review) on type 2 diabetes. The researchers found "moderate-quality" evidence supporting the use of aloe vera to lower blood sugar levels in people with type 2 diabetes. Many unknowns remain, including which form of aloe vera supplement is most effective. It's worth noting that aloe vera gel and gel-based products (i.e., aloe juice, typically made from the gel) were the most common forms used in the studies.

People living with type 2 diabetes often experience changes in cholesterol and triglycerides, referred to as dyslipidemia. An overview of systematic reviews assessed the effect of aloe vera on cholesterol and triglyceride levels. A significant difference in LDL (bad cholesterol) was not seen with aloe vera supplementation. However, a significant increase in HDL (good cholesterol) was noted. Additionally, a significant reduction in triglyceride levels was seen in the aloe vera group.

Gastrointestinal Health

Aloe vera's effects on gastrointestinal (GI) health is another area of interest for researchers and those affected by GI conditions. Conditions such as irritable bowel syndrome, inflammatory bowel disease, and gastroesophageal reflux disease are common and disruptive to many people's lives. These conditions are common and impact the quality of life. A closer look at aloe vera and whether it can affect these conditions is warranted.

Irritable Bowel Syndrome (IBS)

Researchers have studied aloe vera for its impact on IBS, a disorder of the gut-brain axis (previously called function GI disorders). Irritable bowel syndrome is diagnosed by the signs and symptoms of those with the condition when there isn't another apparent cause. Signs and symptoms may include one or a combination of the following:

  • Abdominal pain
  • Abdominal discomfort
  • Constipation
  • Diarrhea

The evidence that aloe vera can reduce IBS symptoms is weak. A review of studies looking at the impact of aloe vera (in gel form and decolorized extract) found that the few studies available in this area showed no real benefit. Ultimately higher-quality research in this area is needed to form any firm conclusions.

Inflammatory Bowel Disease (IBD)

Researchers have studied aloe vera for its effect on a set of conditions called inflammatory bowel disease. These more specific conditions are Crohn's disease and ulcerative colitis. Crohn's disease results in higher levels of inflammation and can impact any portion of the gastrointestinal tract. Ulcerative colitis primarily affects the large bowel (colon, rectum, and anus) but may also affect the last part of the small bowel, the ileum. Symptoms of inflammatory bowel disease are as follows:

  • Abdominal cramps
  • Pain
  • Rectal bleeding
  • Bloody diarrhea

Inflammatory bowel disease can result in severe complications, and additional options are needed to help manage the condition. However, is there evidence that aloe vera can positively impact people with this condition? Little research has been done in this area, and more research is needed.

One early study of 44 people with mild to moderate ulcerative colitis found that aloe vera gel, taken twice daily, had a "response" after four weeks to the treatment more often than those receiving a placebo. By a "response," the authors meant that participants had improvement of their symptoms or remission of the condition. Unfortunately, this is just one small study, and additional research is needed to confirm these results.

Gastroesophageal Reflux Disease (GERD)

GERD is a condition where the movement of stomach contents results in unpleasant symptoms, such as burning (heartburn) or bloating. Those with GERD may experience injury to the lining of their esophagus, which can increase the risk for esophageal cancer, bleeding, and other complications.

Little research has been conducted on aloe vera's impact on gastroesophageal reflux disease (GERD). A small randomized controlled trial including 79 participants compared the effects of aloe vera gel on GERD symptoms, compared with standard treatments. These standard treatments included ranitidine (an H2-receptor antagonist) and omeprazole (a proton pump inhibitor). Researchers ultimately found that the aloe vera gel significantly reduced all symptoms assessed (for example, heartburn, regurgitation, and belching) and had an effect similar to ranitidine and omeprazole. Though the current research may produce optimism, more, higher-quality studies need to confirm the results.

What Are the Side Effects of Aloe Vera?

Side effects of aloe vera are uncommon. The risk of side effects may vary based on the form of aloe vera and whether it is applied to the skin or taken orally.

For example, aloe vera gel appears to be associated with fewer adverse reactions than aloe vera whole leaf extract and aloe latex. The gel has been associated with skin discomfort, pain, and dermatitis in some individuals. Overall, adverse reactions with aloe vera gel appear uncommon and non-severe.

Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain

Severe Side Effects

  • Allergic reaction: When applied to the skin or consumed orally, aloe vera may cause dermatitis, hives, cramping, and diarrhea in those that also have allergies to other plants in the lily family (for example, onions, garlic, and tulips).
  • Hepatitis (liver inflammation): Damage to the liver is more likely to occur when aloe or aloe latex supplements are taken in larger quantities. The exact amount and duration required to have an effect are unknown and likely vary from one person to the next. However, as little as 500 milligrams every two to three days has been associated with hepatitis. The average duration identified by a review of case studies was 60 weeks or about 15 months of supplementation. Data regarding doses of aloe vera latex that have negative side effects are even more limited.
  • Kidney injury: The quantity and duration of aloe vera extract and latex that cause renal (kidney) damage are also limited. A published expert statement from a toxicologist that prolonged use of greater than 1 gram per day of aloe vera latex can result in acute renal failure is commonly quoted. However, the source and quality of this information are unknown.
  • Possible cancer risk: There have long been concerns about an association between laxatives that contain anthraquinones (such as aloe vera) and colorectal cancer. A systematic review and meta-analysis was recently carried out on this topic. This means that researchers reviewed current studies on this topic and combined the data to let us best understand what the recent research says as a whole. The researchers found that the studies had limited quality and could not determine with certainty that there is an association between anthraquinone laxatives and colorectal cancer.

Do Aloe Vera Products Contain Latex?

The aloe plant contains various substances, including latex. The latex contains anthraquinones, which are thought to give aloe latex its laxative effect.

In 2002, the Food and Drug Administration (FDA) required that aloe latex be removed from over-the-counter (OTC) laxative products due to a lack of available safety data. As a result, these products are now sold as nutritional supplements, which the FDA does not as closely regulate.


The use of non-decolorized whole leaf aloe vera extract or latex may pose additional unique risks to specific populations:

  • Pregnancy: Stimulant laxatives, such as aloe vera latex and non-decolorized whole leaf aloe vera extract, should be avoided in pregnancy. This is because there is concern that they may stimulate uterine contraction. This may increase the risk of miscarriage or preterm labor, though research here is very limited.
  • Breastfeeding: Aloe vera latex and non-decolorized whole leaf aloe vera extract should also be avoided when breastfeeding. Little research is available here, but compounds from the aloe vera are transferred to breast milk. This could result in adverse effects, such as diarrhea, in your baby.

The aloe plant contains anthraquinones, which are thought to give aloe latex its laxative effect. However, in 2002, the Food and Drug Administration (FDA) required aloe latex be removed from over-the-counter (OTC) laxative products due to a lack of available safety data. As a result, these products are now sold as nutritional supplements, which the FDA does not as closely regulate.

How Much Aloe Vera Should I Take?

Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.

There are no standard doses of aloe vera in any form. The effects and risk of side effects can vary based on the type of aloe vera supplement, your age, weight, and health status.

Aloe vera gel-based products meant for the skin may be in concentrations as little as 0.5% to over 99%. There is no data to suggest that lower concentrations are less effective than higher concentrations. It may be best to begin with a lower concentration and monitor for improvement of symptoms as well as adverse effects. Adjustments can be made from there as needed in consultation with your healthcare provider. Stop using a supplement immediately if you notice any adverse effects.

Oral forms of aloe may come in capsules, powders, and juices. Supplement doses available vary significantly, and this is partly related to the type of aloe vera supplement as well. Please remember that aloe vera latex and non-decolorized whole leaf extract are associated with more adverse effects than aloe vera gel. You should discuss the use of all nutritional supplements with your healthcare provider, especially when using those with a higher risk of adverse reactions.

Aloe vera gel is relatively safe and doses of 300 milligrams (mg) taken twice daily appear to be associated with improvements in blood sugar. Doses of 500 milligrams taken twice daily appears to be associated with improvements in blood sugar and lipids (cholesterol and triglycerides).

What Happens if I Take Too Much Aloe Vera?

Aloe vera can be toxic if you take too much, especially for an extended period. Toxicity means that the aloe vera begins having negative effects on the body, which can even be life-threatening.

While animal studies have shown that aloe vera gel can have toxic effects, there is little evidence of this in humans. Aloe vera gel may have adverse effects when applied to the skin, such as discomfort, pain, and dermatitis. There is no evidence that aloe vera gel has toxic effects in humans when taken orally. However, nutritional supplements are loosely regulated in the United States, and the quality of supplements varies. If aloe vera latex is not correctly removed from an aloe vera gel supplement, the risk of toxicity will be greater. Stop using the product immediately and consult with your healthcare provider if symptoms are severe or persistent.

Aloe vera latex and non-decolorized whole leaf extract (which contains the latex) have a greater toxicity risk than aloe vera gel. Unfortunately, the amount and duration required to produce toxicity are unclear. However, as little as 500 milligrams per day of non-decolorized whole leaf extract has been associated with adverse effects. The average duration identified by a review of case studies was 60 weeks or about 15 months of supplementation.

It is unclear if a safe and effective amount of aloe vera latex exists. Experts have stated that high doses, such have 1 gram per day, can be fatal. Due to the uncertainty regarding the amount of non-decolorized whole leaf extract and latex required to cause toxicity, these products should be avoided unless recommended by your healthcare provider.


Aloe vera may interact with certain medications. This means it may have the opposite effect of drugs you already take. Or it may ultimately result in a greater overall impact. This can lead to problems with side effects or the treatment of your existing health conditions.

Speaking with your healthcare provider before adding supplements or alternative medicine products is always a good idea. That's especially true if you are taking:

  • Diabetes medications, including insulin: Aloe vera gel can reduce blood sugar. If you're already taking medications that reduce blood sugar, your blood sugar levels could go too low.
  • Laxatives: As aloe vera latex and non-decolorized whole leaf extract act as laxatives, taking this along with other laxatives could result in diarrhea. This may increase the risk of dehydration and electrolyte abnormalities.
  • Diuretics (water pills) like Lasix (furosemide): The laxative effects of aloe vera latex and non-decolorized whole leaf extract can cause diarrhea and the loss of water and potassium in the stool. Furosemide and other loop diuretics result in the loss of potassium in the urine in addition to water. Diuretics and certain aloe vera products could increase the risk of dehydration and low potassium blood levels (if using a loop diuretic like furosemide).
  • Heart rhythm medications like digoxin: Low blood potassium levels can increase the risk of toxic effects from digoxin. As aloe vera latex and non-decolorized whole leaf extract increase the risk of low potassium levels, they could also increase the risk of toxicity from digoxin.
  • Anticoagulants (such as aspirin, warfarin, and enoxaparin): Research has shown that aloe vera can also act similar to anticoagulants (or blood thinners) and reduce blood's ability to clot. Taking aloe vera with anticoagulant medications could therefore increase the risk for bleeding.

It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications.

How to Store Aloe Vera

Store aloe vera in a cool, dry place. Keep it away from direct sunlight. Discard the supplement as recommended by the manufacturer on the packaging.

Similar Supplements

There are other supplements with effects that overlap with aloe vera. Several are listed below.

Other aloes, senna, rhubarb, and cascara sagrada are all anthraquinone laxatives, similar to aloe vera. Magnesium may have laxative effects. Turmeric (Curcuma longa) and its biologically active component, curcumin, have been associated with other benefits similar to aloe vera. For example, curcumin has been associated with improvements in blood sugar and possibly skin health.

Sources of Aloe Vera & What to Look For

Pure aloe vera gel contains healing amino acids, fibers, lipids, sterols, and vitamins. The gel from the plant is safe to eat, but you should not consume store-bought aloe vera gel.

Aloe vera products include topical gels, juice, and oral capsules.

These are approved for cosmetic or dietary supplement use, but are not intended to treat any medical condition. They are also not tested for quality or safety.

Since few aloe vera supplements are certified by the U.S. Pharmacopeia (USP) or similar certifying bodies, stick with well-known brands with an established market presence.


People have used Aloe vera for medicinal purposes for centuries. It remains an alternative medicine option today, but the research supporting its health benefits is limited.

Its most common use is its application to the skin to assist in burn healing. There is weak evidence to support its effectiveness in supporting recovery from ultraviolet radiation and thermal burns. Additionally, a limited amount of evidence supports aloe vera's ability to improve blood sugar and lipids. Additionally, more research is needed regarding the effect of aloe vera on gastrointestinal conditions.

Finally, aloe vera latex, also found in non-decolorized whole leaf extract, has laxative properties. However, latex is also associated with more adverse effects than aloe vera gel. Due to this, you mustn't use this product before talking with your healthcare provider. To be safe, you should always discuss with your healthcare provider before beginning a new nutritional supplement.

Frequently Asked Questions

  • Who is at risk for an aloe vera allergy?

    People with known allergies to other plants in the lily family are at risk for an aloe vera allergy. Members of the lily family that are commonly eaten include onion and garlic.

  • How do I care for an aloe vera plant?

    Plant it in a potting mix for cactus and other succulent plants. Keep the aloe vera in bright, indirect light. Let the top third of the soil dry out before watering so the roots don't rot.

  • How do you get aloe vera gel out of the plant?

    With clean hands, snip one of the leaves close to the bottom of the plant. Put the cut side down in a glass to allow the latex to drain for about 10 minutes. Then remove the leaf spikes and use a vegetable peeler to get to the clear gel inside. Scoop it out and store in a clean container.

41 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Center for Complementary and Integrative Health. Aloe vera.

  2. Surjushe A, Vasani R, Saple DG. Aloe vera: a short reviewIndian J Dermatol. 2008;53(4):163-166. doi:10.4103/0019-5154.44785

  3. Food and Drug Administration. Does FDA approve cosmetics before they go to market.

  4. Food and Drug Administration. Code of Federal Regulations Title 21.

  5. Suksomboon N, Poolsup N, Punthanitisarn S. Effect of Aloe Vera on Glycaemic Control in Prediabetes and Type 2 Diabetes: A Systematic Review and Meta-AnalysisJournal of Clinical Pharmacy and Therapeutics. 2016;41(2):180-188. doi:10.1111/jcpt.12382

  6. Guo X, Mei N. Aloe vera: a review of toxicity and adverse clinical effectsJ Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016;34(2):77-96. doi:10.1080/10590501.2016.1166826

  7. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial aloe vera gel in the treatment of slight to moderate psoriasis vulgarisJ Eur Acad Dermatol Venerol. 2005;19(3):326-331. doi: 10.1111/j.1468-3083.2004.01186.x

  8. Sahebnasagh A, Ghasemi A, Akbari J, et al. Prevention of acute radiation-induced proctitis by aloe vera: a prospective randomized, double-blind, placebo controlled clinical trial in pelvic cancer patientsBMC Complement Med Ther. 2020;20(1):146. doi:10.1186/s12906-020-02935-2

  9. Teplicki E, Ma Q, Castillo DE, et al. The effects of aloe vera on wound healing in cell proliferation, migration, and viabilityWounds. 2018;30(9):263-268.

  10. Nejatzadeh-Barandozi F. Antibacterial activities and antioxidant capacity of aloe vera. Org Med Chem Lett. 2013;3(1):5. doi:10.1186/2191-2858-3-5

  11. Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD008762.pub2

  12. Burusapat C, Supawan M, Pruksapong C, Pitiseree A, Suwantemee C. Topical aloe vera gel for accelerated wound healing of split-thickness skin graft donor sites: a double-blind, randomized, controlled trial and systematic reviewPlast Reconstr Surg. 2018;142(1):217-226. doi:10.1097/PRS.0000000000004515

  13. Beikert FC, Schönfeld BS, Frank U, Augustin M. Antiinflammatorische Wirksamkeit von 7 Pflanzenextrakten im Ultraviolett-Erythemtest. Eine randomisierte, placebokontrollierte Studie [Antiinflammatory potential of seven plant extracts in the ultraviolet erythema test. A randomized, placebo-controlled study]. Hautarzt. 2013;64(1):40-46. doi:10.1007/s00105-012-2505-x

  14. Haesler E. Evidence summary: wound management low resource communities - aloe vera for wound healingWound Practice & Research: Journal of the Australian Wound Management Association. 2017;25(2). doi:10.3316/informit.927808614590746

  15. Talbott W, Duffy N. Complementary and alternative medicine for psoriasis: what the dermatologist needs to knowAmerican Journal of Clinical Dermatology. 2015;16(3):147-165. doi:10.1007/s40257-015-0128-6

  16. Centers for Disease Control and Prevention. National Diabetes Statistics Report.

  17. Araya-Quintanilla F, Gutiérrez-Espinoza H, Cuyul-Vásquez I, Pavez L. Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: an overview of systematic reviewsDiabetes Metab Syndr. 2021;15(6):102292. doi:10.1016/j.dsx.2021.102292

  18. Khavandi M, Duarte F, Ginsberg HN, Reyes-Soffer G. Treatment of dyslipidemias to prevent cardiovascular disease in patients with Type 2 diabetesCurrent Cardiology Reports. 2017;19(1). doi:10.1007/s11886-017-0818-1

  19. Canavan C, West J, Card T. The epidemiology of irritable bowel syndromeClin Epidemiol. 2014;6:71-80. doi:10.2147/CLEP.S40245

  20. Rosen MJ, Dhawan A, Saeed SA. Inflammatory dowel disease in children and adolescents. JAMA Pediatr. 2015;169(11):1053-1060. doi:10.1001/jamapediatrics.2015.1982

  21. Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R. The changing epidemiology of gastroesophageal reflux disease: are patients getting younger? J Neurogastroenterol Motil. 2018;24(4):559-569. doi:10.5056/jnm18140

  22. Wilmes L, Collins JM, O’Riordan KJ, O’Mahony SM, Cryan JF, Clarke G. Of bowels, brain and behavior: a role for the gut microbiota in psychiatric comorbidities in irritable bowel syndromeNeurogastroenterology & Motility. 2021;33(3). doi:10.1111/nmo.14095

  23. Farmer AD, Wood E, Ruffle JK. An approach to the care of patients with irritable bowel syndromeCMAJ. 2020;192(11):E275-E282. doi:10.1503/cmaj.190716

  24. Fifi A, Axelrod C, Chakraborty P, Saps M. Herbs and spices in the treatment of functional gastrointestinal disorders: a review of clinical trialsNutrients. 2018;10(11):1715. doi:10.3390/nu10111715

  25. Langmead L, Feakins RM, Goldthorpe S, et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis: ALOE VERA FOR ULCERATIVE COLITISAlimentary Pharmacology & Therapeutics. 2004;19(7):739-747. doi:10.1111/j.1365-2036.2004.01902.x

  26. Clarrett DM, Hachem C. Gastroesophageal reflux disease (GERD)Mo Med. 2018;115(3):214-218.

  27. Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Sahebkar A. Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trialJ Tradit Chin Med. 2015;35(6):632-636. doi:10.1016/s0254-6272(15)30151-5

  28. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitisAnn Pharmacother. 2007;41(10):1740-1743. doi:10.1345/aph.1K132

  29. Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature reviewKorean J Gastroenterol. 2014;64(1):54-58. doi:10.4166/kjg.2014.64.1.54

  30. Tovar RT, Petzel RM. Herbal toxicityDis Mon. 2009;55(10):592-641. doi:10.1016/j.disamonth.2009.05.001

  31. Lombardi N, Crescioli G, Maggini V, et al. Anthraquinone laxatives use and colorectal cancer: a systematic review and meta-analysis of observational studiesPhytother Res. 2022;36(3):1093-1102. doi:10.1002/ptr.7373

  32. Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M. Is it safe to consume traditional medicinal plants during pregnancy?Phytother Res. 2021;35(4):1908-1924. doi:10.1002/ptr.6935

  33. Kopec K. Herbal medications and breastfeedingJ Hum Lact. 1999;15(2):157-161. doi:10.1177/089033449901500219

  34. Finn D, Sett A, Ryan CA. Aloe vera induced toxic colitis in a breast-feeding baby: a case reportCase Reports in Perinatal Medicine. 2013;2(1-2). doi:10.1515/crpm-2013-0021

  35. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with aloe vera in pre-diabetic subjects: a randomized controlled-trialJ Diabetes Metab Disord. 2015;14:22. doi:10.1186/s40200-015-0137-2

  36. Leonard CE, Razzaghi H, Freeman CP, Roy JA, Newcomb CW, Hennessy S. Empiric potassium supplementation and increased survival in users of loop diureticsPLoS One. 2014;9(7):e102279. Published 2014 Jul 16. doi:10.1371/journal.pone.0102279

  37. Chan KE, Lazarus JM, Hakim RM. Digoxin associates with mortality in ESRD. J Am Soc Nephrol. 2010;21(9):1550-1559. doi:10.1681/ASN.2009101047

  38. Abebe W. Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenuesEPMA J. 2019;10(1):51-64. doi:10.1007/s13167-018-0158-2

  39. Lombardi N, Crescioli G, Maggini V, et al. Anthraquinone laxatives use and colorectal cancer: a systematic review and meta-analysis of observational studies. Phytother Res. 2022;36(3):1093-1102. doi:10.1002/ptr.7373

  40. Marton LT, Pescinini-E-Salzedas LM, Camargo MEC, et al. The effects of curcumin on diabetes mellitus: a systematic reviewFront Endocrinol (Lausanne). 2021;12:669448. doi:10.3389/fendo.2021.669448

  41. Vollono L, Falconi M, Gaziano R, et al. Potential of curcumin in skin disordersNutrients. 2019;11(9):2169. doi:10.3390/nu11092169

Additional Reading

By Brandon Petrovich, RD
& peer-reviewed author with over five years of work in nutrition and healthcare.

Originally written by
Cathy Wong
Cathy Wong

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

Learn about our editorial process