Antibiotics Used to Treat Acne

Antibiotics are frequently used to treat moderate to severe acne that is not responsive to other treatments. Some, like tetracycline, are commonly prescribed. Others, like amoxycillin, less so. But in all cases, antibiotics are used to help decrease the number of bacteria that become trapped in and around hair, hair follicles, and sebaceous glands.

Aside from taming breakouts, antibiotics can help limit consequences like permanent scarring, which occurs in about 20% of all people living with severe acne. While effective, these drugs have side effects that should be considered.

This article details the antibiotics commonly used to treat acne and how they work. It presents information about side effects, as well as the growing problem of antibiotic resistance that may affect how and when they're prescribed.

A girl touching the acne on her face
Bunlue Nantaprom / EyeEm/Getty Images

How Antibiotics Work on Acne

Antibiotics work by several mechanisms. The most important one is the decrease in the number of acne-related bacteria in and around the hair follicle.

Specifically, the follicle becomes obstructed and an overgrowth of normal skin bacteria destroys the lining of the follicle. As a result, the bacteria and debris enter the dermis layer of the skin, causing an inflammatory response.

Antibiotics also work by reducing the irritating chemicals produced by white blood cells. Finally, antibiotics reduce the concentration of free fatty acids in the sebum, also reducing the inflammatory response.

How Long Does It Take For Antibiotics to Clear Acne?

Generally speaking, expect to use antibiotics for three to four months before you notice significant acne improvement. The recommended course will, however, differ depending on the medication used and your skin.

Some people may take an antibiotic for much longer, with one study of amoxicillin reporting an average duration of 37 weeks. Your dermatologist will ensure they're prescribing safe and effective treatment.

It's important to complete the full course of any antibiotic treatment prescribed for acne. Don't expect immediate results.


Tetracycline was once the most widely prescribed class of antibiotic for acne, but it's the tetracycline derivatives like doxycycline and minocycline that are more commonly used today.

There are several antibiotics within the entire class, including tetracycline, which remains available in both 500-milligram (mg) and 250-mg formulations.

The usual starting dose is 500 mg twice a day continued until a significant decrease in acne lesions is seen. The dose can then be decreased to 250 mg twice a day or discontinued.

Tetracycline should not be given to people who are pregnant or children under 9 years of age.

Tetracycline may cause stomach upset. Eating it with non-dairy foods is often advised, as dairy products decrease absorbtion and render it less effective.


Minocin (minocycline) is a tetracycline derivative that has been used effectively for decades as a treatment for acne. It is especially useful for pustular type acne. A pustule is a pus-containing vesicle such as a whitehead surrounded by redness.

While the absorption of minocycline is decreased with food, it is not as significant as the decrease seen with tetracycline. The usual starting dose is 50 to 100 mg twice a day.

Major side effects of minocycline include dizziness, nausea, vomiting, skin pigmentation changes, and tooth discoloration. The skin and tooth changes are seen more often in people who have taken minocycline for a long time.

Minocycline (and theoretically any tetracycline derivative) should be avoided in those who are using Accutane (isotretinoin) as the combination of these may result in a condition in which there is increased pressure within the skull (pseudotumor cerebri).


Doxycycline is often used for people who do not respond to or cannot tolerate erythromycin or tetracycline, or for those who will likely have difficulty with the "no food" guidelines of some drugs.

The dosage of doxycycline is started at 50 mg to 100 mg twice a day. It should be taken with food; otherwise, it can cause significant nausea.

Doxycycline is more likely than tetracycline to increase sensitivity to the sun or cause sunburns, a phenomenon known as photosensitivity. There are other acne medications that may cause photosensitivity as well, such as benzoyl peroxide, alpha-hydroxy acids, and topical retinoids.

Doxycycline is available under these brand names: Doryx, Oracea, Monodox, Atridox, Morgidox, Vibra-Tabs, Alodox, Ocudox, Doxy, Acticlate, and Vibramycin.


Click Play to Learn More About Doxycycline Acne Treatments

This video has been medically reviewed by Casey Gallagher, MD.


Amoxicillin is not considered a first-line drug for treating acne. However, a study of 26 people who were first treated with other antibiotics without success found that 85% of them saw improvement with amoxicillin when used alongside topical treatments and/or hormone therapy.

Amoxicillin for acne has certain advantages. High among them is that it is safe for use in pregnant people. It can be used when drugs in the tetracycline class aren't an option.

It typically has fewer side effects, though nausea, diarrhea, and headache can occur.

Amoxicillin for acne also may be a good option for people with allergies to doxycycline and other first-line drugs. A daily dose of 1000 mg, or in more serious cases 1500 mg, appears to work well.

In the United States, amoxicillin is sold under brand names including:

  • Amoxicot
  • Amoxil
  • DisperMox
  • Moxilin
  • Trimox

However, because it's in the penicillin class of antibiotics, it can't be used in people with penicillin allergies or, in some cases, those diagnosed with certain health conditions. Tell your healthcare provider about these conditions, which include:

  • Kidney disease
  • Asthma
  • Hay fever
  • Mononucleosis

Septra/Bactrim and Macrolides

Septra or Bactrim (sulfamethoxazole/trimethoprim) and Zithromax (azithromycin) a macrolide, have often been used to treat moderate to severe inflammatory acne.

Studies do not seem to favor one antibiotic over another with this condition, but treatment appears to work much better when combined with topical therapy.

Allergic reactions (sulfa allergy) are fairly common with sulfanomides, and significant resistance has been seen with both of these categories of antibiotics.

Topical Antibiotics

Clindamycin is most widely prescribed as a topical antibiotic. The starting dose is 75 to 150 mg twice a day.

The major side effect of oral clindamycin therapy (which is rarely used anymore) is a serious intestinal infection called pseudomembranous colitis caused by the bacteria, Clostridioides difficile (C. difficile or C. diff).

A C. difficile infection is much more common with oral clindamycin but has been reported with the topical product as well.

Topical clindamycin is available as Cleocin-T, Clinda-Derm, Clindagel, Clindets, C/T/S, and Evoclin.

Antibiotic Side Effects

All antibiotics can cause vaginal yeast infections. Tetracycline seems to be the antibiotic that most frequently has this side effect.

All oral antibiotics can also lessen the effectiveness of birth control pills, so those who are taking these antibiotics should use a backup birth control method. Nausea is fairly common with erythromycin and doxycycline.

It's important to talk to your dermatologist about any potential side effects and when you should call with any symptoms.

Concerns About Antibiotic Resistance

In recent years, healthcare professionals have been seeing increasing resistance of the bacteria Propionibacterium acnes against the oral antibiotics used.

Current strategies to reduce resistance recommend using antibiotics in combination with topical treatments and limiting the duration of use when possible. This, however, has impacted the overall effect of antibiotics on acne.

As is the case with prescribing any medication, the risks have to be weighed against the rewards. Discuss all of your options with your healthcare provider.

While short-term use of antibiotics is generally considered best, not finishing a recommended course of one of these drugs can actually contribute to the problem of antibiotic resistance.

A Word From Verywell

Antibiotics can be very helpful for some people with acne and work by a combination of mechanisms. Some antibiotics work better for particular types of acne and your dermatologist can make the best choice by understanding your history of acne as well as your lifestyle.

As with any medications, side effects may occur. Fortunately, there are several different choices available if one of the above is not helpful. Antibiotics are usually used in combination with topical treatments and good daily skin care for acne-prone skin.

Frequently Asked Questions

  • Which antibiotic is best for acne?

    The most effective and safe antibiotic treatment for acne depends on the case and the type of acne. Doxycycline remains among the most commonly prescribed antibiotics for acne, along with minocycline and sarecycline.

  • Can amoxicillin worsen acne?

    Some topical antibiotics can lead to symptoms associated with skin purging, such as dry and flaky skin. This is when acne appears worse for up to a few weeks because of an interruption of the skin cell-replacement process. Systemic antibiotic like amoxicillin are less likely to cause this, however.

14 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945-73.e33. doi:10.1016/j.jaad.2015.12.037

  2. Baldwin H. Oral Antibiotic Treatment Options for Acne Vulgaris. J Clin Aesthet Dermatol. 2020 Sep;13(9):26-32. Epub 2020 Sep 1. PMID: 33133338

  3. McLaughlin J, Watterson S, Layton AM, Bjourson AJ, Barnard E, McDowell A. Propionibacterium acnes and acne vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studiesMicroorganisms. 2019;7(5):128. doi:10.3390%2Fmicroorganisms7050128

  4. American Academy of Dermatology. How Long Can I Take an Antibiotic to Treat My Acne?

  5. Guzman AK, Choi JK, James WD. Safety and effectiveness of amoxicillin in the treatment of inflammatory acne. Int J Womens Dermatol. 2018 Jun 8;4(3):174-175. doi:10.1016/j.ijwd.2018.03.006.

  6. Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009;1(3):162–169. doi:10.4161/derm.1.3.9364

  7. Goetze S, Hiernickel C, Elsner P. Phototoxicity of doxycycline: A systematic review on clinical manifestations, frequency, cofactors, and prevention. Skin Pharmacol Physiol. 2017;30(2):76-80. doi:10.1159/000458761

  8. MedlinePlus. Amoxicillin: Drug information.

  9. Bienenfeld, A., Nagler, A., and S. Orlow. Oral antibacterial therapy for acne vulgaris: An evidence-based review. American Journal of Clinical Dermatology. 2017 Aug;18(4):469-490. doi:10.1007/s40257-017-0267-z

  10. Tan CB, Rajan D, Shah M, et al. Toxic megacolon from fulminant Clostridium difficile infection induced by topical silver sulphadiazineBMJ Case Rep. 2012;2012:bcr2012006460. doi:10.1136/bcr-2012-006460

  11. Gonçalves B, Ferreira C, Alves CT, Henriques M, Azeredo J, Silva S. Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors. Crit Rev Microbiol. 2016;42(6):905-27. doi:10.3109/1040841X.2015.1091805

  12. Tan AU, Schlosser BJ, Paller AS. A review of diagnosis and treatment of acne in adult female patientsInt J Womens Dermatol. 2017;4(2):56–71. doi:10.1016/j.ijwd.2017.10.006

  13. Adler B, Kommehl H, Armstrong A. Antibiotic resistance in acne treatment. JAMA Dermatology. 2017;153(8):810-811. doi:10.1001/jamadermatol.2017.1297

  14. Liu H, Yu H, Xia J, Liu L, Liu GJ, Sang H, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. Cochrane Database Syst Rev. 2020 May 1;5(5):CD011368. doi:10.1002/14651858.CD011368.pub2.

Additional Reading
  • Weller, Richard P. J. B., Hamish J.A. Hunter, and Margaret W. Mann. Clinical Dermatology. Chichester (West Sussex): John Wiley & Sons Inc., 2015. Print.

By Heather L. Brannon, MD
Heather L. Brannon, MD, is a family practice physician in Mauldin, South Carolina. She has been in practice for over 20 years.