Allergies Common Treatments Antihistamines and How They're Used By Daniel More, MD Daniel More, MD, is a board-certified allergist and clinical immunologist. He is an assistant clinical professor at the University of California, San Francisco School of Medicine and currently practices at Central Coast Allergy and Asthma in Salinas, California. Learn about our editorial process Daniel More, MD Medically reviewed by Medically reviewed by John Carew, MD on January 02, 2020 twitter linkedin John Carew, MD, is board-certified in otolaryngology and is an adjunct assistant professor at New York University Medical Center. Learn about our Medical Review Board John Carew, MD Updated on January 23, 2020 Print Histamine is a chemical that's normally produced in your body and stored in allergic cells, such as mast cells and basophils. If you have allergies, histamine is released from these cells in a response to allergens. Your histamine binds to the histamine receptor which is present on various cells in your body and results in allergic symptoms such as sneezing, itchy eyes, itchy nose, hives, or even anaphylaxis. Antihistamines are medications that block the receptor for histamine, thereby stopping the symptoms that histamine causes like sneezing, runny nose, itchy eyes, and swollen throat. Mario Tama Collection / Getty Images Most Common Uses of Antihistamines Antihistamines are commonly used for the treatment of various allergic diseases, and can be taken in oral, nasal spray, eye drop, and injected forms. The diseases antihistamines are used for include: Hay fever (allergic rhinitis): Newer oral antihistamines, such as Xyzal (levocetirizine), Zyrtec (cetirizine), Allegra (fexofenadine), Clarinex (desloratadine), and Clarinex (desloratadine), are very effective therapies for the treatment of hay fever. Older antihistamines, like diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), and hydroxyzine (Atarax), also work well but have many side effects. Oral antihistamines work well when they're taken as-needed, meaning that your allergy symptoms improve within an hour or two of taking the medication. Antihistamines are also available as nasal sprays for the treatment of allergic rhinitis (nasal allergies). Nasal antihistamine sprays include Astelin (azelastine) and Patanase (olopatadine). Corticosteroid nasal sprays are often used to treat allergies as well. Examples of these include Rhinocort (budesonide), Flonase (fluticasone propionate), Nasonex (mometasone), and Nasacort Allergy 24 Hour (triamcinolone). Eye allergies: Oral antihistamines can help treat the symptoms of eye allergies. They're also available as eye drops, such as Optivar (azelastine), Emadine (emedastine), Visine-A (pheniramine), and Alaway (ketotifen). Corticosteroid eye drops may be used to treat eye allergies when antihistamines don't work. Examples include Flarex (fluorometholone), Alrex (loteprednol), and Omnipred (prednisolone). Hives (urticaria): Oral antihistamines are the main treatment for hives. Newer, low-sedating antihistamines, such as Zyrtec or Claritin, are preferred over the older, sedating antihistamines such as Benadryl or Atarax. Topical antihistamine creams, present in many forms of over-the-counter anti-itch creams, should not be used for the treatment of hives or other skin allergies because using topical antihistamines on the skin, such as Benadryl cream, can cause contact dermatitis due to the antihistamine. Other Uses for Antihistamines Antihistamines are frequently used for the treatment of other allergic conditions, although they may not be as effective as they are for hay fever and hives. These conditions may include: The common cold Itching of the skin (pruritus) Insect stings and bites Allergic reactions to medications Anaphylaxis Common Oral Antihistamines Common oral antihistamines include these categories: Over-the-counter (OTC): Probably the most well-known oral antihistamine is Benadryl, which is an older, sedating antihistamine. While Benadryl is a reasonable medication for the treatment of various allergic conditions, side effects limit its routine use, especially during the daytime. Benadryl, and many other older antihistamines, such as Chlor-Trimeton (chlorpheniramine), are available OTC without a prescription. Newer, less-sedating antihistamines, Claritin, Allegra, and Zyrtec, are also available OTC without a prescription. These medications cause much less sedation and are therefore preferred over the older, sedating forms. Prescription only: While many older, sedating antihistamines are now available OTC, Atarax is still only available by prescription. Atarax is extremely sedating and is commonly prescribed for the treatment of skin allergies such as hives and itching. The active metabolite of Atarax, Zyrtec, is available OTC and causes much less sedation. Xyzal and Clarinex, two less sedating antihistamines, are still available only by prescription, as is Periactin (cyproheptadine). Side Effects Older antihistamines, such as Benadryl and Atarax, have a significant amount of anticholinergic side effects, including dry mouth, drowsiness, constipation, headache, and urinary retention. Because of the side effects of these medications, they are generally considered to be too sedating for routine daytime use. Since older antihistamines can impair mental and motor functioning, they can diminish your ability to operate motor vehicles or heavy machinery. In many states, you can be charged with driving-under-the-influence (DUI) if you operate a motor vehicle while taking medications such as Benadryl. Newer, low-sedating antihistamines, such as Claritin and Zyrtec, tend to have fewer anticholinergic side effects. While these newer antihistamines may still cause drowsiness or a dry mouth, they haven’t been shown to impair your ability to operate a motor vehicle. Allegra is the only antihistamine that is truly considered to be non-sedating. Weight Gain In addition to sedation and dry mouth, antihistamines may have the unwanted side effect of increased appetite and weight gain. This may be due to the similar chemical structure of antihistamines and certain psychiatric medications, such as anti-depressants, which are known to increase appetite and lead to weight gain. In fact, numerous people who have used Xyzal reported an increase in appetite and weight gain. The package insert for Xyzal confirms weight gain as a known side effect but reports this as only occurring in 0.5 percent of people in studies who were taking this medication. Older antihistamines, such as Periactin (cyproheptadine), have actually been used for the purpose of increasing appetite and weight gain in underweight children and cancer patients undergoing chemotherapy. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Scadding GK. Optimal management of allergic rhinitis. Arch Dis Child. 2015;100(6):576-82. doi:10.1136/archdischild-2014-306300 Church MK, Church DS. Pharmacology of antihistamines. Indian J Dermatol. 2013;58(3):219-24. doi:10.4103/0019-5154.110832 Ross A, Fleming D. Hayfever--practical management issues. Br J Gen Pract. 2004;54(503):412-4. PMID: 15186559 Yadav S, Bajaj AK. Management of difficult urticaria. Indian J Dermatol. 2009;54(3):275-9. doi: 10.4103/0019-5154.55641 Additional Reading Seresirikachorn K, Khattiyawittayakun L, Chitsuthipakorn W, Snidvongs K. Antihistamines for treating rhinosinusitis: systematic review and meta-analysis of randomised controlled studies. J Laryngol Otol. 2018;132(2):105-110. doi:10.1017/S002221511700192X.