Antihistamines for Treating Nasal Allergies

Second-generation antihistamines are generally preferred

Histamine is a chemical released from allergic cells in the body (such as mast cells and basophils), usually in response to an allergen like cat dander or pollen.

When histamine is released by allergic cells in the nose and eyes, the result is sneezing, runny nose, itchy eyes/nose/throat, nasal congestion, and post-nasal drip. These are the symptoms of hay fever, also known as allergic rhinitis.

Antihistamines are medications that block the receptor for histamine, thereby stopping the symptoms that histamine causes. Antihistamines are the most commonly used medications to treat allergic rhinitis.

Antihistamines in blister pack
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Examples of Antihistamines

Older antihistamines, called first-generation antihistamines, include:

These antihistamines have significant side effects termed “anticholinergic” side effects, which may include dry mouth, sleepiness, constipation, and urinary retention. Because of the side effects of these medications, they are generally considered to be too sedating for routine daytime use.

Therefore, this article will only discuss the newer antihistamines, as described below.

Newer antihistamines, called second-generation antihistamines include:

  • Zyrtec (cetirizine)
  • Allegra (fexofenadine)
  • Clarinex (desloratadine) 
  • Claritin, Alavert (loratadine)
  • Xyzal (levocetirizine) 
  • Astelin, Astepro (azelastine)

Each of the medications on the list above have a generic version available. These newer antihistamines tend to have fewer anticholinergic side effects and therefore are termed “low-sedating” or “non-sedating.”

It's important to note that montelukast (Singulair) is not an antihistamine, but rather an antileukotriene medication. Leukotrienes are chemicals released from a variety of allergic and immune cells and may cause allergy symptoms, including nasal congestion.

What Symptoms of Hay Fever Do Antihistamines Treat?

Antihistamines block the action of histamine, and histamine-related symptoms include:

  • Sneezing
  • Runny nose
  • Itchy eyes
  • Itchy nose
  • Itchy ears
  • Itchy throat

Other symptoms, including post-nasal drip, cough, and nasal congestion may also be caused by histamine, and therefore can be treated by antihistamines.

However, antihistamines are generally less effective at treating post-nasal drip and nasal congestion symptoms, since other chemicals other than histamine may be involved.

Which Antihistamine Works the Best?

The answer to this question is completely based on my experiences and opinions as a board-certified allergist. Studies are very helpful in deciding which medication works best, but it also must be kept in mind which company is paying for the study.

It is my opinion that Zyrtec (cetirizine) and Allegra (fexofenadine) are very closely matched, and very good antihistamines. I think these medications work much better than either Claritin (loratadine) or Clarinex (desloratadine). At the present time, I feel that Zyrtec is the best antihistamine available in the U.S. for the treatment of allergic rhinitis.

Which Antihistamine Causes the Least Amount of Sedation?

The topic of sedation is an important one. Sedation refers to the concept that someone feels tired. This is different than impairment, which refers to the concept that someone’s ability to perform various mental and physical tasks is affected.

The only truly non-sedating antihistamine currently available is Allegra. Zyrtec causes sedation 5% to 10% more than placebo. Claritin and Clarinex cause minimal sedation. None of these second-generation antihistamines, when used in recommended doses for allergic rhinitis, have been shown to result in impairment. This is in comparison to the older antihistamines, such as Benadryl, which are well known to result in the impairment of mental and physical tasks.

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8 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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