Antipyrine and Benzocaine Otic Solution (Aurodex) for Ear Pain

Antipyrine and benzocaine otic solution is a medication that is used for ear pain, specifically pain caused by acute otitis media (middle ear infections). This medication may also reduce inflammation in the ear. It is intended to be used at the same time as an approved antibiotic for the treatment of an ear infection.

A woman with an earache using her ear drops

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Who Can Use It

Antipyrine and benzocaine otic solution should not be used by individuals who currently have synthetic ventilation tubes in their ears or by individuals who may have a ruptured or otherwise impaired eardrum. Using this medication when the eardrum is damaged may cause inner ear damage to occur. Check with your doctor or pharmacist and inform them of any medications, prescription or over-the-counter that you may be taking prior to using this medication. You should not use this medication if you are allergic to any of the ingredients including antipyrine or benzocaine.

How It's Used

Antipyrine and benzocaine otic solution comes in liquid form, typically in a bottle with a dropper. It may be more comfortable and less likely to cause dizziness if it is warmed prior to being put into the ear. You can do this by either holding it in your hands for a few minutes or running the bottle under warm (not hot) water for a few minutes. Ear drops are best administered by a second person if possible.

  1. The person receiving the drops should lay down on their side with the affected ear up.
  2. The ear should be pulled slightly back and up in order to straighten out the ear canal.
  3. After the prescribed number of drops are placed in the ear the person receiving the drops should continue to lay on their side for a minute or two so that the medication can fully penetrate the ear canal.
  4. You may also wish to moisten a small piece of cotton with the drops and place it in the outer ear.

This medication is usually used as needed, sometimes as frequently as every hour (follow the directions on the bottle), in order to control pain. You do not need to worry if you miss a dose but pain control will be best achieved by using the medication at regular intervals.

This medication is only intended to be used in the ears, do not get it in your mouth or eyes. If you accidentally swallow this medication you should contact poison control immediately at 1-800-222-1222.

Side Effects

As with all medications, it is possible to have an allergic reaction to antipyrine and benzocaine otic solution. Signs of an allergic reaction include itching, redness, or hives. A serious allergic reaction may cause difficulty breathing, swelling or the face, mouth, lips or throat. If you have symptoms of a serious allergic reaction go to the emergency room or call 911 immediately.

Other side effects of this medication include burning or stinging when the ear drops or first applied. You should contact your doctor if you experience any of the following side effects: ear discharge or drainage, new or worsening redness or the ear or a rash, increased ear pain.

Be aware of the following, particularly if your child is nonverbal. If you notice an increase in pain or you notice they start swallowing more frequently when you insert the drops stop using the ear drops until you see a physician. This can occur if your child has intact ear tubes or a ruptured eardrum. The pain is a result of the medication flowing into the inner ear, and the swallowing is a result of the fluid draining through the eustachian tube into the back of your child's throat. Continued use without seeing a physician could result in ear damage if the eardrum is not completely whole.

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Article Sources
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  • Medline Plus. Antipryine-Benzocaine Otic.