Can Antispasmodics Treat IBS?

How drugs target smooth muscle to alleviate symptoms

Studies have suggested that as many as 20% of Americans experience the symptoms of irritable bowel syndrome (IBS), a functional gastrointestinal disorder that causes abdominal pain and changes in bowel habits.

As researchers have yet to identify the cause of IBS, treatment is primarily aimed at relieving the symptoms of the disorder (including abdominal pain, cramping, bloating, diarrhea, and constipation).

Among the various drugs used to treat IBS, antispasmodics have proven moderately effective in alleviating symptoms by targeting and relaxing the smooth muscles of the digestive tract. Since the symptoms tend to be most profound after a person has eaten, the drugs are typically taken 30 to 60 minutes before a meal.

There are several different types of antispasmodic used to treat IBS, including:

Woman with stomach issues
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Anticholinergics are a class of drug designed to block the compound acetylcholine. This is the chemical produced by the body that acts on the autonomic nervous system (the part of the nervous system associated with involuntary functions).

By blocking acetylcholine receptors in the digestive tract, anticholinergics can decrease the severity of muscle spasms and the overproduction of mucus. Unfortunately, the drug can also affect other organ systems, triggering side effects ranging from blurred vision and constipation to decreased urination and dizziness.

Due to the risk of constipation, anticholinergics are best used in cases of diarrhea-predominant IBS (IBS-D) rather than constipation-predominant IBS (IBS-C). Gastric reflux is also a common side effect.

The most commonly prescribed anticholinergics include:


Mebeverine is a musculotropic spasmolytic that works similarly to anticholinergics but does not have the acetylcholine side effects. Allergic reactions have been reported in some, mostly in the form of low-grade rashes.

Mebeverine is commonly prescribed to people with IBS and is available under many different brand names including Colofac, Duspamen, and Duspatalin.

Peppermint Oil

Peppermint oil is an over-the-counter supplement that contains menthol, a substance which appears to have a relaxing effect on smooth muscle.

A 2014 review of studies by the University of California, San Diego concluded that persons with IBS symptoms were nearly three times more likely to achieve relief with peppermint oil compared to those provided a placebo.

While considered safe for short-term use, peppermint oil is known to cause heartburn (a situation which may be avoided with the use of enteric-coated capsules). Be sure to consult your doctor before taking peppermint oil or any other over-the-counter supplement.

Peppermint oil should be used with caution in people with heartburn, hiatal hernia, severe liver damage, gallbladder inflammation, or bile duct obstruction.

Dietary Changes

In addition to antispasmodic medications, dietary changes can also significantly improve IBS symptoms. Depending on the types you're experiencing, you may want to:

  • Increase dietary fiber or use a fiber supplement to relieve IBS constipation or diarrhea.
  • Increase water intake if constipated.
  • Avoid caffeine (peppermint tea is an excellent substitute).
  • Avoid legumes to decrease bloating.
  • Limit foods containing lactose, fructose, or FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols).
  • Take a daily probiotic to maintain healthy digestive flora.
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  4. Alammar N, Wang L, Saberi B, et al. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. BMC Complement Altern Med. 2019;19(1):21. doi:10.1186/s12906-018-2409-0

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