Digestive Health Inflammatory Bowel Disease Surgery Are Probiotics Helpful For Pouchitis? By Amber J. Tresca Amber J. Tresca Facebook LinkedIn Twitter Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16. Learn about our editorial process Updated on August 14, 2022 Medically reviewed by Jay N. Yepuri, MD, MS Medically reviewed by Jay N. Yepuri, MD, MS Facebook LinkedIn Twitter Jay Yepuri, MD, MS, is board-certified in gastroenterology. He is a partner with Digestive Health Associates of Texas and a medical director at Texas Health Harris Methodist HEB Hospital. Learn about our Medical Expert Board Print Pouchitis is a condition that can affect people who have had j-pouch (ileal pouch-anal anastomosis [IPAA]) surgery for ulcerative colitis. The mechanism of pouchitis is not well understood, and it is thought that it might include several different types of disease. It is the most common complication in people with j-pouches. KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images Symptoms of pouchitis can include: more frequent and urgent bowel movementsabdominal crampingrectal bleedingfever Pouchitis typically responds to treatment with antibiotics but can recur in about two-thirds of patients. About 10% of patients experience recurring pouchitis that does not respond to antibiotic therapy. These recurring bouts of pouchitis can cause a decrease in the quality of life for people with a j-pouch. Getting treatment for pouchitis, especially in the period right after surgery, is very important. Anyone who has had pelvic pouch surgery should contact their doctor right away when the pouch seems "off" and there are symptoms of pain, fever, and blood in the stool. Why Would Probiotics Help? Researchers discovered that people who experience pouchitis have fewer beneficial bacteria, namely lactobacilli and bifidobacteria, in their digestive tract. The next logical step was to conduct trials to see whether increasing the beneficial bacteria in the digestive tract would help improve the symptoms of pouchitis. Supplements of these beneficial bacteria are called "probiotics" and may include a wide variety of live bacterial strains. The Evidence For the Use of Probiotics The American Gastroenterology Association (AGA) released clinical practice guidelines in 2020 regarding the use of probiotics for managaing digestive health conditions, including pouchitis. For adults and children, the group conditionally recommends a combination of eight strains of probiotics as opposed to other probiotics or none at all. The eight strains are L paracasei subsp paracasei, L plantarum, L acidophilus, L delbrueckii subsp bulgaricus, B longum subsp longum, B breve, B longum subsp infantis, and S salivarius subsp thermophilus over no or other probiotics. The AGA guidelines further note that patients for whom the feasibility and cost of using this combination of bacterial strain is problematic may reasonably select no probiotics. As far as specific research goes, there have been several meta-analyses investigating the safety and effectivness of probiotics for managing symptoms associated with pouchitis. Certain probiotics, different for each process, have proven to be effective and beneficial in cases of pouchitis and other digestive health complications. The Bottom Line While the medical evidence is sparse on the topic of probiotics, it is fair to say that while probiotics may help for maintaining remission, they are not necessarily helpful in treating acute pouchitis. Your physician will be able to help you determine when probiotics are useful for pouchitis, as well as which product to use, and how much to take. Important points to remember: Probiotics may be helpful for maintaining remission after pouchitis has been treated with antibiotics or in delaying the initial onset of pouchitisProbiotics have not yet proven helpful in treating acute, severe pouchitisIt is important to discuss the use of probiotics with a physician to ensure that the proper type and amounts are takenThe evidence for use of probiotics is not yet complete, and results of future studies may change use of probiotics for pouchitis 2 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Su G, Ko C, Bercik, P, ET al. AGA clinical practice guidelines on the role of probiotics in the management of gastrointestinal disorders. Gastroenterology. June 9 2020. doi:10.1053/j.gastro.2020.05.059 Sebastián Domingo JJ. Review of the role of probiotics in gastrointestinal diseases in adults. Gastroenterol Hepatol. 2017;40(6):417-429. doi:10.1016/j.gastrohep.2016.12.003 Additional Reading Liu Z1, Song H, Shen B. Pouchitis: Prevention and treatment. Curr Opin Clin Nutr Metab Care. Sep 2014;17(5):489-95. doi:10.1097/MCO.0000000000000094 By Amber J. Tresca Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit