How Do Artificial Sweeteners Stack Up Against Each Other?

Comparing 5 Major Sweeteners on the Market

Artificial sweetener packets
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Americans eat an average of 20 teaspoons of sugar a day, according to the U.S.Food and Drug Administration (FDA). And most of this sugar is hidden in the foods we buy.

Sugar is found in obviously sweet foods, like sodas and packaged baked goods, and also in the not-so-obvious, like spaghetti sauces and canned soups. But, artificial sweeteners replace sugar and cut calories in a host of products from oatmeal to fruit juice.


Artificial sweeteners are so much sweeter than sugar that very small amounts are needed to create a sweet taste. That is what minimizes the calories of the sweeteners.

Artificial sweeteners contribute almost no carbohydrates to foods, so people with diabetes can enjoy their favorite foods without affecting blood glucose levels. Keep in mind, however, that even "sugar-free" foods may still contain carbohydrates which become sugar in your body.

While there are many artificial sweeteners in foods (you can spot sugar alcohols on food labels by their "ol" ending), these are the five major FDA-approved artificial sweeteners on the market.


Saccharin is the original artificial sweetener, developed in 1879. After being suspected of causing bladder cancer in rats in 1972, many studies were done which ultimately disproved any link to cancer.

According to the National Cancer Institute, "Human epidemiology studies (studies of patterns, causes, and control of diseases in groups of people) have shown no consistent evidence that saccharin is associated with bladder cancer incidence." 

Times sweeter than sugar: 200 to 700

Brand names: Sweet N' Low, Sweet Twin and Necta Sweet.


Aspartame was approved by the FDA in 1981. Its chemical compound breaks down into a substance known as phenylalanine. This can pose a danger for people who have phenylketonuria (PKU), but overall aspartame is considered safe for the general public.

Times sweeter than sugar: 200 

Brand names: Equal and Nutrasweet


Acesulfame-K was approved in 1988 as a "tabletop sweetener" and in 2003 as a general purpose sweetener. It is not metabolized by the body, which means that no calories are absorbed when it's digested. It is frequently blended with other artificial sweeteners.

Times sweeter than sugar: 200 

Brand names: Sweet One and Sunett


Sucralose is derived from sugar, but it is 600 times sweeter. It isn't absorbed by the body, so it does not add calories to foods. In 1999, it was approved as a general purpose sweetener. It can also be used in home baking to reduce calories in homemade foods.

Times sweeter than sugar: 600

Brand name: Splenda


Neotame is a cousin to aspartame and is the most intensely sweet of the artificial sweeteners. It was approved in 2002 as a general purpose sweetener. Although it is related to aspartame, it doesn't carry the same warning about phenylalanine since only a minimal amount is produced during digestion.

Times sweeter than sugar: 7,000 to 13,000

Brand name: Newtame

Artificial Sweetener Reference

Artificial Sweeteners
Generic Name Brand Name Sweetness Factor Uses Additional Facts FDA Approval
Saccharin Sweet'N Low, Sweet Twin, Necta Sweet, Equal 200 to 700 times sweeter than sugar Tabletop sweetener, beverages, baked goods, jams, gum Heat stable 1879
Aspartame Nutrasweet 200 times sweeter than sugar In processed foods and beverages Not heat stable 1981
Acesulfame-K Sunett, Sweet One 200 times sweeter than sugar General purpose Heat stable to 392 degrees F 1998
Sucralose Splenda 600 times sweeter than sugar General purpose Can be used in home baking 1998
Neotame Newtame 7,000 to 13,000 times sweeter than sugar General purpose Similar to aspartame 2002

Does Splenda cause cancer? Read more.

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Article Sources
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  1. Bowman SA, Clemens JC, Martin CL, Anand J, Steinfeldt LC, and Moshfegh AJ. Added Sugars Intake of Americans: What We Eat in America, NHANES 2013-2014. Food Surveys Research Group. Dietary Data Brief No. 18. May 2017

  2. Food and Drug Administration. Additional Information about High-Intensity Sweeteners Permitted for Use in Food in the United States. Updated February 8, 2018.

  3. National Cancer Institute. Artificial Sweeteners and Cancer. Reviewed August 10, 2016.

  4. van Wegberg AMJ, MacDonald A, Ahring K, et al. The complete European guidelines on phenylketonuria: diagnosis and treatmentOrphanet J Rare Dis. 2017;12(1):162. Published 2017 Oct 12. doi:10.1186/s13023-017-0685-2

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