9 At-Home Syphilis Tests We Recommend in 2023

If you think you have syphilis, an at-home test can help you get on the road to treatment

We independently evaluate all recommended products and services. If you click on links we provide, we may receive compensation. Learn more.

If you’ve recently been exposed to the sexually transmitted infection (STI) syphilis, it’s crucial to get tested to ensure the safety of yourself and your partner(s). While you should always consult a medical provider if you think you may have an STI, some people may not have immediate access to a doctor, nurse or clinic able to perform testing. Fortunately, at-home tests provide a convenient and discreet option for initial STI testing. However, it’s important that you not use at-home testing in place of a visit to a health care provider. No at-home test is infallible and, while these convenient diagnostics can offer some insights, they cannot replace the expertise and thorough physical exam a medical professional provides. 

The best at-home syphilis tests utilize reputable labs that are accredited by Clinical Laboratory Improvement Amendments (CLIA) or the College of American Pathologists (CAP) to ensure that proper lab protocols are being followed. In addition, they offer post-result support from in-house healthcare providers for those who test positive for syphilis or other STIs. If your test is positive, the testing lab is required to report it to the public health department and may also ask you to cooperate with partner notification. You should also see a qualified medical professional immediately for confirmation and treatment. 

We collected data on and researched dozens of companies that offer at-home syphilis tests processed by high-quality labs to put together this list..  We considered factors such as price, convenience, and medical support; we also consulted with Lindsay Modglin, a subject matter expert with over a decade of healthcare experience. Finally, this article was medically reviewed by Dr. Chris Vincent, MD, an expert in family medicine.

Our Top Nine Picks for At-Home Syphilis Testing in 2023

For Quick Shipping : My LabBox At Home Syphilis Test


My LabBox

My LabBox

Key Specs
  • Cost: Approximately $89
  • Availability: 49 states
  • Time for Results: 2-5 days
Pros & Cons
Pros
  • Results in 2-5 days

  • Free standard shipping

  • $45 overnight shipping available

Cons
  • More expensive than other syphilis-only tests

  • Not available in New York

Why We Chose It

The myLabBox At Home Syphilis Test is easy to use, moderately priced, tests only for syphilis, and offers results as quickly as two to five days after the lab receives your sample. We also particularly like the overnight shipping option for $45. It costs approximately $89 and is shipped for free. You have the option to pay for the test with a regular credit card or you can use your flexible spending account (FSA) or health savings account (HSA) card.

When the test arrives, you will need to activate the kit online before collecting your finger-prick blood sample. Once you take the sample and submit it by mail, you can expect to receive an email to alert you when your results are available (typically within two to five days after the lab receives the sample). 

This test checks only for syphilis, and the results are read at a CLIA- and CAP-accredited laboratory. However, it’s not available for residents of New York.

For Accuracy : LetsGetChecked Complete 8


LetsGetChecked Complete 8

LetsGetChecked

Key Specs
  • Cost: Approximately $249
  • Availability: 49 states
  • Time for Results: 2-5 days
Pros & Cons
Pros
  • Results in 2-5 days

  • CLIA-accredited and ISO-accredited labs

  • Tests for 8 different STIs

Cons
  • More expensive than other STI tests

  • Not available in New York

  • Some complaints of slow results

Why We Chose It

Complete 8 test from LetsGetChecked is analyzed by CLIA-certified laboratories, the same caliber of lab used by hospitals and doctors, as well as ISO-accredited, which specifically evaluates lab test accuracy. The at-home test costs approximately $249 with free shipping and can be paid for using your FSA or HSA card. For a more budget-friendly option, you can sign up for a subscription, which allows you to save 30% by having a test delivered every three months for about $174.30.

This comprehensive test checks for chlamydia, gonorrhea, HIV, syphilis, mycoplasma, ureaplasma, trichomoniasis, and Gardnerella. After ordering the test online and receiving your kit, you will need to activate it and then collect a finger-prick blood sample and a urine sample. Once you return the sample and it’s received by the lab (all are ISO-accredited and CLIA-accredited), your results will be ready to view within two to five days.

An extra benefit of this test is that if you have a positive result, you can consult with one of LetsGetChecked’s healthcare providers for $39. The company also provides medication for chlamydia, mycoplasma, ureaplasma, trichomoniasis, and Gardnerella. With the LetsGetChecked app (for iOS or Android), you can order tests, track your tests, and view results. Note that this test isn’t available in New York.

For For Ease of Use : LetsGetChecked Standard 5


LetsGetChecked

LetsGetChecked

Key Specs
  • Cost: Approximately $149
  • Availability: 49 states
  • Time for Results: 2-5 days
Pros & Cons
Pros
  • Tests for five common STIs

  • Results in 2-5 days

  • Certain medications provided at no extra cost

Cons
  • More expensive than syphilis-only tests

  • Not available in New York

  • Reviewers say results may be slow in some cases

Why We Chose It

The LetsGetChecked Standard 5 test not only comes with clear directions for collecting your samples, but there is a helpful instructional video that demonstrates exactly how to use its test. The Standard 5 kit is priced at $149 with free shipping, and you can pay for it using a credit card as well as with HSA or FSA funds. If you opt to sign up for a LetsGetChecked subscription, you'll receive one test every three months at a 30% discount (or about $104.30 per test).

This test kit checks for chlamydia, gonorrhea, HIV, syphilis, and trichomoniasis, and can be ordered online through the LetsGetChecked website. Once you receive it, you will need to activate the test and collect your finger-prick blood sample and urine sample. After you submit the sample, the CLIA-certified lab will analyze your kit and return your results to view online within two to five days.

With a positive result, you can get a phone consultation with one of LetsGetChecked’s healthcare providers for $39. If needed, medication for chlamydia and trichomoniasis are included for no extra fee.

The LetsGetChecked app allows you to order and track tests, view your test results, and more. However, the kit can’t be purchased in New York.

Our Budget Pick : EverlyWell Syphilis Test


EverlyWell Syphilis Test

EverlyWell

Key Specs
  • Cost: Approximately $69
  • Availability: 49 states
  • Time for Results: 5-7 business days
Pros & Cons
Pros
  • Inexpensive

  • CLIA-certified

  • Provider follow up for positive results

Cons
  • Slower results than other companies

  • Not available in New York

  • Can't contact customer service by phone

  • Not for people who've been reinfected with syphilis

Why We Chose It

At $69, EverlyWell’s Syphilis Test is one of the most affordably-priced options for at-home syphilis testing. Additionally, if you sign up for a membership, you can get this test or another similarly priced one for about $24.99 per month. You also have the option to use FSA or HSA funds to pay for these tests.

After ordering the kit online and receiving it, you will need to activate it before you collect your finger-prick blood sample. Once the kit is registered and you’ve collected your sample, submit it to the lab according to the mailing instructions included in the test. Your results should be ready in five to seven business days after being analyzed by EverlyWell’s CLIA-accredited lab.

It's important to note that this test screens for a type of antibody that remains in your system after you've had—and been treated for—syphilis. Therefore, if you've previously had syphilis but are concerned you've been reinfected, this is not the test for you to take. This test is also not available in New York.

For a Subscription : iDNA Syphilis Test


iDNA

iDNA 

Key Specs
  • Cost: $78
  • Availability: 49 states
  • Time for Results: two to seven Days 
Pros & Cons
Pros
  • Test takes five minutes to complete

  • Price is on the lower end

  • Free shipping both ways

Cons
  • Only tests for syphilis

  • Can’t pay using FSA or HSA funds

Why We Chose It 

You can buy a single iDNA Syphilis Test for $78. Or, you can opt to subscribe to iDNA for $50 a month. The membership includes either one free test (for syphilis or any iDNA test of your choosing) or one free doctor consultation per month. With a subscription, any additional doctor consultations or tests will be discounted.  iDNA makes the sample collection and testing process straightforward with clear, simple instructions.i It only takes five minutes to complete and easy-to-read results are delivered through the company’s online portal. You can pay for this test using a regular credit card, but you cannot use FSA or HSA funds. 

Once your kit arrives, you’ll need to register it online. Then, follow the instructions included with the kit to collect a blood sample (you do not need to fast before taking the sample). Once everything is packed up, you will ship it back to iDNA for free. Processing will take two to seven days after the kit has been delivered to the lab; when testing is complete you’ll receive an email alerting you that your results are available through the portal. Unfortunately, a medical provider consultation is not included with the test kit, so if you want help interpreting your results, you’ll have to book a separate appointment with an iDNA provider (for $80 without a membership) or other medical professional. 

The iDNA Syphilis Test is not available in New York. 

For Multiple STIs : My LabBox Total Box


My LabBox

My LabBox

Key Specs
  • Cost: Approximately $369
  • Availability: 49 states
  • Time for Results: Two to five days
Pros & Cons
Pros
  • Tests for 14 different STIs

  • Results in 2-5 days

  • CLIA- and CAP-accredited

Cons
  • HPV testing costs extra

  • Expensive

  • Shipping and results may be slower than advertised

Why We Chose It

The comprehensive Total Box from My LabBox tests for 14 different STIs, including HIV I and II, hepatitis C, herpes simplex type II, syphilis, genital/throat/rectal chlamydia, genital/throat/rectal gonorrhea, trichomoniasis, Mycoplasma genitalium, and HPV (for an extra fee, for people with vaginas). It costs $369 at full price with free First Class Mail shipping, but you can save on each box by subscribing to receive one test every six months ($332.10 per test). You also can pay for your tests using your FSA or HSA card.

After ordering the test, receiving your kit, and activating it, you need to take four different samples: a finger-prick blood test, urine sample (for people with penises) or vaginal swab , rectal swab, and oral swab. Then, you’ll box your samples and submit them. The lab should have your results ready in two to five days after receiving your samples.

My LabBox works with CLIA- and CAP-accredited labs, and if any of your tests come back positive, you’ll have an opportunity to speak with one of their healthcare providers for no extra fee. Note that the kit is not available in New York. 

For Medical Support : Nurx Basics Covered STI Home Test Kit


Nurx Basics Covered STI Home Test Kit

Nurx 

Key Specs
  • Cost: $44.50+ with insurance; approximately $179.50 without  
  • Availability: 34 states
  • Time for Results: Up to seven business days
Pros & Cons
Pros
  • Accepts insurance

  • Comes with one year of unlimited messaging with provider

  • Tests for four STIs

Cons
  • Required provider consultation is additional cost

  • Slower results

Why We Chose It 

The Nurx Basics Covered STI Home Kit includes a consultation with a medical professional as well as unlimited messaging with your medical team for a full year whether you test positive or not. It tests for syphilis, HIV, chlamydia, and gonorrhea and has a self-pay price at $150 plus a required $15 provider consultation and $14.50 service fee. You can save quite a bit on the test if you pay through insurance, as the test cost drops to as low as $29.50 (plus the $15 consultation fee). Nurx does accept HSA and FSA funds for payment. 

In order to get a test kit,Nurx requires a virtual consultation with one of its providers. From there, you can order your kit, which will be shipped to you for free. Once the kit arrives, you’ll follow instructions to collect urine and blood samples, then you’ll ship them back to Nurx for free. You will receive results within seven days after the sample arrives at the lab. 

Regardless of whether your tests come back positive or negative, you will have access to free unlimited messaging with a provider for a full year after your initial consultation. Nurx is currently unavailable for residents living in Alaska, Arizona, Arkansas, Delaware, Hawaii, Idaho, Kansas, Minnesota, Mississippi, Nevada, New Hampshire, New Mexico, North Dakota, Oklahoma, Vermont, and West Virginia.

For Same-Day Results : Priority STD Syphilis Test


Priority STD

Priority STD

Key Specs
  • Cost: $69 
  • Availability: 44 states
  • Time for Results: Approximately 24 hours or less
Pros & Cons
Pros
  • Same-day results

  • FDA-approved

  • Less expensive than many alternatives

Cons
  • Requires going to a lab

  • Labs may be far from you

  • Does not accept insurance

Why We Chose It

If you need to know your syphilis status as soon as possible, your best bet is to order a test through Priority STD and go to a lab for sample collection. With Priority STD, you don’t need to see a clinician to order a test. You can order it yourself online and head to the nearest affiliate lab. While you sacrifice the privacy of a fully at-home experience, in many cases, you’ll be able to get your test results the same day you order the syphilis test.

To order a syphilis test from Priority STD, you’ll head to its website, search for and select the test you want (you can order a standalone syphilis test, or the 10-Panel STD Test, which includes testing for syphilis, gonorrhea, chlamydia and seven other common STIs), then search for your nearest lab. Priority STD will send the order to the lab and you can head there at your earliest convenience; no need to schedule an appointment (but keep in mind, you may have to wait if others have arrived before you). A technician will draw your blood to be tested for syphilis. The whole process will take about five minutes. You’ll get an email notifying you your results are ready to view through a secure login, usually within 24 to 72 hours. 

A standalone syphilis test costs $68 from Priority STD. Or, you can be tested for syphilis and nine other STIs with the company’s 10-panel test, for $198.

For a Fast Full Panel : STDcheck.com Full 10 Test Panel


stdcheck.com

stdcheck.com

Key Specs
  • Cost: $139, or $259 to include HIV RNA early detection 
  • Availability: 50 states
  • Time for Results: Less than 24 hours
Pros & Cons
Pros
  • Results typically in one to two days

  • FDA-approved

  • Option to add on early HIV detection test

  • Doctor consultation available with positive test

Cons
  • Requires going to a lab

  • No consultation if you no positive results or only a positive HSV-1 test

  • Does not accept insurance

Why We Chose It 

While you’re getting tested for syphilis, you may want to go ahead and find out whether you have any other STIs. If you want to know quickly, we recommend STDcheck.com’s full 10 test panel, which includes tests for HIV, gonorrhea, chlamydia and other common infections. We particularly like that you can choose to add on early HIV testing, which can detect infection in as little as 10 days after exposure. You don’t need a prescription and can order your own test. 

The downside of STDcheck.com is that you’ll have to go to one of its 4,500 partner labs for sample collection (rather than doing this yourself, at home), although patients can often get tested the same day they place their order. Unlike most fully at-home tests, STDcheck.com’s are fully FDA-cleared and approved. The inconvenience of going to a lab is also what ensures speedy results. You can choose your panel from its website, find the most convenient lab location for you. While STDcheck.com does have labs in every state, keep in mind that there may not be one particularly close to you, or you may have to cross state lines to get to the nearest one. In this case, STDcheck.com may not be right for you. 

STDcheck.com’s full 10 test panel costs $139, unless you add on early HIV detection, which bumps the price up to $259. The company doesn’t accept insurance, but you can pay with an HSA/FSA card. Results are generally available in one to two days and, if you test positive for anything, you have the option of a free consultation with a doctor. Free consults are not offered if your results are all negative, or if you only test positive for HSV-1 (the form of herpes responsible for oral cold sores, which is extremely common).

Compare the Best At-Home Syphilis Test

Company  Cost Time for Results Availability (# of States) Sample Collection Method
myLAB Box At Home Syphilis Test For Quick Shipping Approx. $89 2-5 days 49 Finger prick
LetsGetChecked Complete 8 For Accuracy Approx. $249 2-5 days 49 Finger prick, urine sample
LetsGetChecked Standard 5 For Ease of Use Approx. $149 2-5 days 49 Finger prick, urine sample
Everlywell Syphilis Test Our Budget Pick Approx. $69 5-7 business days 49 Finger prick
iDNA Syphilis Test For a Subscription Approx. $78 2-7 business days 49 Finger prick
myLAB Box Total Box For Multiple STIs Approx. $369 2-5 days 49 Finger prick, vaginal swab or urine sample, oral swab, rectal swab
Nurx Basics Covered STI Home Test Kit For Medical Support Approx. $44.50+ with insurance; $179.50 without  Up to 7 business days 34 Finger prick, urine sample
Priority STD Syphilis Test For Same-Day Results $69 Approx. 24 hours or less 44 Blood draw
STDcheck.com Full 10 Test Panel For a Fast Full Panel $139 ($259 with early HIV test add-on) 1-2 days 50 Blood draw, urine sample

How to Choose the Best  At-Home Syphilis Test for You

Comparing At-Home Syphilis Tests

When choosing which home syphilis test is best for you, consider the following factors:

  • Cost: The price for syphilis and multiple-STI tests can range from roughly $30 to more than $300, depending on how many STIs are tested with the kit.
  • Time for results: For faster results, you may want to go with LetsGetChecked. It offers results in as little as two days.
  • Accuracy: All of the kits and companies mentioned in this list use CLIA- and/or CAP-accredited labs, which helps ensure that proper lab protocols for safety and accuracy are followed.
  • Privacy: Each of these testing companies sends your test in discreet packaging and keeps your personal health data completely private by adhering to HIPAA law.
  • Number of STIs tested: You can test for syphilis alone, but some tests check for up to 14 separate STIs; more STIs included in a test will increase the price.
  • Availability: These tests are not available in New York.

Key Considerations

What is Syphilis?

Syphilis is a sexually transmitted infection (STI) that causes sores, which are usually painless, in the genital area, but can be asymptomatic. It’s easily curable but, if left untreated, it can move into the central nervous system, heart, liver and bones and can even be fatal to someone with an undiagnosed infection, or to an infant who contracts the infection during pregnancy. It can spread during any kind of sexual contact when one person has an active infection, which they are often unaware of. It affects people of every gender, sexual orientation and race equally, although risks are higher when you have multiple sexual partners or don’t use protection such as condoms. 

It takes about three weeks for syphilis symptoms (including sores in the genital areas) to become apparent or detectable, and is asymptomatic in about half of cases. A blood test is the only way to confirm a syphilis diagnosis, but this should be paired with medical care.

When Should I Take an At-Home Syphilis Test?

If you know or suspect you’ve been exposed to syphilis, you should take a test three weeks after your exposure, even if you don’t have symptoms, since not everyone who gets syphilis has noticeable signs. If you have symptoms, you should still test as well as see a health care provider. Left undiagnosed and untreated, syphilis can spread to your central nervous system and to sexual partners (even if you don’t have intercourse). 

How Syphilis Is Diagnosed 

If you suspect you may have syphilis, you should see a medical professional for testing and a physical exam. Syphilis is a bacterial infection that spreads through sexual contact, when skin comes into contact with a sore caused by the infection, called a chancre. Cancers typically don’t develop until about three weeks after infection. They are often painless and may be in hard-to-see spots like the vagina, rectum or underside of the penis. As a result, they often go undiagnosed. Medical professionals look for these sores, but always use blood tests to confirm a diagnosis. 

An at-home or self-ordered test should never replace a visit to a clinician. But, if you’ve waited long enough to test, they can give you an idea of your status before confirming with a clinic, doctor or nurse practitioner. Even if your home test is not positive, you should still cross-check the results with a qualified provider. While the tests listed here have been validated (meaning they were tested for accuracy), many at-home STI tests are not FDA cleared (the testing equivalent of approval).

Ordering Your Syphilis Test Kit

After you’ve chosen the test you want to purchase, order the kit directly from the company website. When you receive the kit in the mail, thoroughly read through all of the instructions. Usually, you will need to activate your kit before you collect your sample. After activation, follow the instructions to collect your sample, repackage it, and mail it to the lab. Once you receive your results, you will have an opportunity to discuss them with a healthcare provider and potentially receive a prescription for treatment if you qualify.

Syphilis Tests and FDA-Approval 

You may notice that not all at-home syphilis tests are approved or cleared by the FDA. Diagnostic tests can get “cleared” (a lower bar of proof) by the FDA if they are similar enough to other diagnostics that have already been cleared. Diagnostic testing consists of two general components: Sample collection and the device(s) involved and the test analysis that’s done in the lab. The analysis part of at-home STI tests on this list is done at the same certified labs that doctors send samples to. 

At-home STI tests use the same types of samples as labs (blood, urine, saliva and vaginal and rectal swabs). FDA approval is technically not mandatory for a home syphilis test to go to market because they fall into a regulatory gray-area. The FDA has not approved or cleared at-home sample collection methods, which raises some concern about their reliability. Many companies have done their own tests showing that self-collected samples return equally accurate results on STI tests, and some states send self-collection kits to residents. But so far, the proof hasn’t met the FDA’s standards and any test comes with a risk of false-negatives or false-positives. This is one reason you should always see a health care provider for diagnosis of syphilis. 

Frequently Asked Questions

  • How Much Does an At-Home Syphilis Test Cost?

    Home syphilis tests range from approximately $30 to $300 or more depending on what’s included with the test (if it looks for more STIs, the price tends to be higher).

  • How Soon Can an At-Home Syphilis Test Be Taken?

    Generally, the window period of syphilis is 21 days (three weeks) from exposure because it takes time for antibodies to form in high enough concentrations in your body to be detected by at-home tests. However, because there are different types of syphilis tests on the market, each testing company has different guidelines on the optimum time to do their tests, such as LetsGetChecked, which recommends waiting at least 12 weeks to take its tests. Always check with the company offering the test before taking it.

  • Is an At-Home Syphilis Test Accurate?

    The lab analysis of these tests is accurate, as home syphilis tests are typically read by some of the same labs that read samples collected by healthcare providers. However, user error and contamination during sample collection can lead to inaccurate results. The risk of inconclusive or inaccurate results is nearly eliminated when sample collection is done by technicians in a lab. To ensure accuracy and that proper protocols are followed, look for a home testing company that employs CLIA- or CAP-accredited labs.

  • Who Should Take an At-Home Syphilis Test?

    Anyone who’s had recent sexual contact with someone who has syphilis, or who is unsure if they have syphilis, should take a syphilis test. Additionally, you should test for syphilis if you’re experiencing any of the following symptoms:

    • Round, painless sores (typically in the genital area, but they can appear anywhere)
    • Rough, red, or brown patches on your palms or the soles of your feet
    • Fever
    • Sore throat
    • Headaches
    • Unexplained weight loss or hair loss
    • Unexplained muscle aches or fatigue2

    Those who may be at a higher risk of contracting syphilis include any sexually active people who:

    • Are biological men who have sex with other biological men
    • Have HIV
    • Have a partner with syphilis

Methodology

We collected data on the costs, shipping, accuracy, timelines, availability, insurance coverage, company reputations and validation studies of 10 companies that offer STI-testing. We also searched for other companies and conducted additional research on these. We followed up with the companies to confirm claims made on their websites and ask for documentation of the accuracy of their tests and made sure the companies on this list utilize CLIA- or CAP-accredited laboratories, and offer consultations and/or treatment options with positive results.

Red pen on Immunology form ordering HIV/AIDS blood tests

RapidEye / Getty Images

Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. CDC. "Detailed STD Facts - Syphilis." Retrieved April 24, 2023 from https://www.cdc.gov/std/syphilis/stdfact-syphilis-detailed.htm

  2. Pew. "Diagnostic Tests Not Reviewed by FDA Present Growing Risks to Patients." Retrieved April 25, 2023 from https://www.pewtrusts.org/en/research-and-analysis/fact-sheets/2021/10/diagnostic-tests-not-reviewed-by-fda-present-growing-risks-to-patients

  3. NIH.gov. "At-home specimen self-collection and self-testing for sexually transmitted infection screening demand accelerated by the COVID-19 pandemic: A Review of Laboratory Implementation Issues." Journal of clinical microbiology.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525576/

  4. CDC. gov. Detailed Fact Sheet - Syphilis. https://www.cdc.gov/std/syphilis/stdfact-syphilis-detailed.htm

By Ashley Ziegler
​Ashley Ziegler is a lifestyle writer specializing in motherhood, family health, and consumer products. She has written for Romper, Moms.com, and more. She received her Bachelor of Arts in Communication from Purdue University and her Master of Science in Management from Indiana Wesleyan University.

Edited by Ally Hirschlag
Allison "Ally" Hirschlag

Ally is a senior editor for Verywell, who covers topics in the health, wellness, and lifestyle spaces. She has written for The Washington Post, The Guardian, BBC Future, and more.

Learn about our editorial process