Autoimmune Diseases That Can Be Fatal By Elizabeth Pratt Elizabeth Pratt is a medical journalist based in Australia. She has a Master's degree in Health Communication and a Bachelor's degree in journalism. Learn about our editorial process Elizabeth Pratt Published on December 22, 2020 Print There are over 100 autoimmune diseases, and in the large majority of cases, these diseases are not life-threatening. However, there are some conditions that can be fatal or lead to life-threatening complications. Autoimmune Disease List Here is a closer look at autoimmune disease that can be fatal. Getty Images Giant Cell Myocarditis Giant cell myocarditis is a rare cardiovascular disorder that progresses rapidly and is often fatal. In this disease, there is inflammation in the heart muscle (myocardium). Initial symptoms can include: FatigueShortness of breathSwelling in the anklesChest painHeart palpitations Irregular heartbeats (arrhythmias) can cause light-headedness or loss of consciousness. The average time span from the onset of symptoms to complications that can be life-threatening or the need for a heart transplant is five and a half months. Both men and women can be impacted by giant cell myocarditis and the condition can occur at any age. In the majority of cases, the disease occurs in young or middle-aged people with a median age of 42. It is a rare disease with roughly 300 cases recorded in the literature. There is no proven cure for giant cell myocarditis. Anti-NMDA Receptor Encephalitis Anti-NMDA receptor encephalitis was first recognized as a neurologic disease in 2007. In this autoimmune disease, the immune system creates antibodies against the NMDA receptors in the brain, which play a crucial role in memory. The antibodies interrupt signaling in the brain and cause swelling in the brain, also referred to as encephalitis. Some will also experience tumors that are associated with the disease. The disease mainly affects young people and is more common in women. Anti-NMDA receptor encephalitis can cause a variety of symptoms. Typically, the disease will appear with symptoms that are less severe and progress quickly to the point of hospitalization. Common symptoms include: Changes to behavior (aggression, paranoia, hallucinations)Problems with cognitionDifficulty with memoryProblems with speechLoss of consciousnessAbnormal movements in the face, mouth, arms, and legsSeizures While many cases of anti-NMDA receptor encephalitis will result in a full recovery, in some cases it can be fatal. It’s estimated that roughly 6% of people will die from anti-NMDA receptor encephalitis. Treatment options vary but often involve a combination of tumor removal (if needed), steroids, plasma exchange, and intravenous immunoglobulin. Mixed Connective Tissue Disease Mixed Connective Tissue Disease (MCTD) is a rare condition that can cause pain and inflammation in multiple joints. It is most common in women under 30. MCTD can cause symptoms also seen in lupus, scleroderma, and rheumatoid arthritis. Signs and symptoms can include: Muscle weaknessFeverFatigueBuild-up of fluid in the hands causing puffinessRashesViolet color of the eyelidsHair lossKidney diseaseDysfunction in the esophagus There is no cure for MCTD, but treatment options can help with symptoms from the condition. Over-the-counter remedies can help with pain in the joints and inflammation of muscles. If complications occur—or during disease flares—glucocorticoids may be given. Some people experiencing MCTD will require long term immunosuppressants. Generally speaking, the long-term outlook for those living with MTCD is good, however, this varies based on the symptoms present. Some people will have symptom-free periods that can stretch for years and not require treatment. The 10-year survival rate is 80%, but even with treatment, the disease can worsen in roughly 13% of cases. In these severe cases, the disease can cause potentially fatal complications in six to 12 years of disease onset. Autoimmune Vasculitis Vasculitis causes narrowing and inflammation of the blood vessels, which comprise the arteries, veins, and capillaries. The blood vessels are responsible for carrying blood between the heart and other organs in the body. In this disease, the immune system wrongly attacks the blood vessels, mistaking them for an invader like a virus or bacteria. Vasculitis can occur in isolation or alongside rheumatoid arthritis, lupus, or Sjogren's syndrome. Signs and symptoms vary and are dependent on the organs involved and the severity of the condition. While some people will only experience mild symptoms, other people can become very ill. Common symptoms include fever, weight loss, loss of appetite, fatigue, and generalized aches and pains. Symptoms specific to certain organs throughout the body can include: Lungs: Coughing up blood, shortness of breathGI tract: Stomach pain, sores in the mouth. In severe cases, blockages and rupture of the intestinesEar, throat, nose, and sinuses: Chronic middle ear infections, hearing lossEyes: Redness, itchiness, sensitivity to light, blurred vision, and in rare cases, blindness. Brain: Headaches, problems with cognition, stroke-like symptoms such as paralysisNerves: Numbness or tingles, loss of strength or feeling in hands In severe cases, the disease causes blood vessels to shut, so blood can’t pass through. This can result in an aneurysm. At its severe stage, vasculitis can cause organ damage and death. Treatment options vary based on the severity of the disease and the organs affected. Those who have severe vasculitis receive corticosteroids like prednisolone in an attempt to reduce inflammation in the blood vessels. If these don’t work, anti-rheumatic drugs may be used. Are Autoimmune Disease More Prevalent in Women? There are over 100 types of autoimmune diseases that predominantly affect women. Approximately 80% of all patients diagnosed with autoimmune diseases are women.It's unclear why this is the case, but it's thought that women tend to be more vulnerable to autoimmune disease due to variation within the sex chromosomes and hormonal changes. For example, hormonal changes during puberty and pregnancy. A Word From Verywell In the large majority of cases, autoimmune diseases are not fatal, and those living with an autoimmune disease can expect to live a regular lifespan. There are some autoimmune diseases that can be fatal or lead to life-threatening complications, but these diseases are rare. If you are concerned about your health or worry you may have an autoimmune disease, speak with your doctor. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. American Autoimmune Related Diseases Association. Giant cell myocarditis. National Organization For Rare Disorders. Giant cell myocarditis. Penn Medicine. Could your loved one have autoimmune encephalitis? Updated June 13, 2016. Penn Medicine. Anti-NMDAR encephalitis. National Center For Advancing Translational Sciences. Mixed connective tissue disease. Arthritis Foundation. Vasculitis. Invernizzi P, Pasini S, Selmi C, Gershwin ME, Podda M. Female predominance and X chromosome defects in autoimmune diseases. Journal of Autoimmunity. 2009;33(1):12-16. doi:10.1016/j.jaut.2009.03.005