Average Wholesale Price of HIV Drugs

The wholesale price of HIV drugs is determined by a number of factors. Firstly, the manufacturer releases a wholesale acquisition cost (WAC), which is essentially the asking price of a drug before any discounts or rebates are added for volume purchases and/or prompt payment.

Pills on split across twenty dollar bills
Chris Potter / Flickr / CC BY 2.0

From this, a suggested wholesale price (SWP) is set. This is the price recommended by the manufacturer to wholesalers when determining prices for their customers, including retailers, hospitals, and institutions. The SWP is not the actual transactional cost, but rather a baseline from which wholesalers can make competitive pricing decisions.

By contrast, the average wholesale price (AWP) is the average price that retailers and others are reportedly paying for a particular drug. The AWP is reported by the manufacturers and compiled by independent publishers. That data is used by governments, insurance companies, and others to determine the reimbursement and retail prices of prescription drugs.

Because AWP relies on third-party reporting—and is, therefore, vulnerable to price manipulation—some institutions have begun to abandon its use in favor of the SWP.

Finally, the direct price (DIRP or DP) is the price a non-wholesale buyer—namely, you—would expect to pay at the cash register. Generally speaking, there's a 20% to 30% markup between the WAC and DIRP.

Here are the average wholesale prices for antiretroviral drugs per month (as of 12/18/2019).

Drug Adult Strength Dose Count AWP per month
Aptivus (tipranavir) 250mg capsule 2 twice daily 120 $2,008
Atripla (tenofovir disoproxil + emtricitabine + efavirenz) 300/200/600mg tablet 1 daily 30 $3,429
Biktarvy (bictegravir + tenofovir alafenamide + emtricitabine) 50/25/200mg tablet 1 daily 30 $3,707
Cabenuva (cabotegravir + rilpivirine) 400/600 mg by injection 1 injection of each monthly 1 $4,752 (estimated) 
Cimduo (lamivudine + tenofovir disoproxil) 300/300mg tablet 1 daily 30 $1,207
Combivir (zidovudine + lamivudine) 300/150mg tablet 1 twice daily 60 $1,082
Complera (tenofovir disoproxil + emtricitabine + ripilvirine) 300/200/25mg tablet 1 daily 30 $3,375
Delstrigo (doravirine + lamivudine + tenovofir disoproxil) 100/300/300mg tablet 1 daily 30 $2,464
Descovy (tenofovir alafenamide + emtricitabine) 25/250mg tablet 1 daily 30 $2,109
Dovato (dolutegravir + lamivudine) 50/300mg tablet 1 daily 30 $2,754
Edurant (rilpivirine) 25mg tablet 1 daily 30 $1,338
Emtriva (emtricitabine) 200mg capsule 1 daily 30 $644
Epivir (lamivudine) 300mg tablet 1 daily 30 $499
Epzicom (abacavir + lamivudine) 600/300mg tablet 1 daily 30 $1,550
Evotaz (atazanavir + cobicistat) 350/150mg tablet 1 daily 30 $1,927
Fuzeon (enfuvirtide) 90mg injection 1 twice daily 60 $4,303
Genvoya (elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide) 150/150/200/10mg tablet 1 daily 30 $3,708
Intelence (etravirine) 200mg tablet 1 twice daily 60 $1,628
Isentress (raltegravir) 400mg tablet 1 twice daily 60 $1,889
Isentress HD (raltegravir) 600mg tablet 1 twice daily 60 $1,889
Juluca (dolutegravir + rilpivirine) 50/25 mg tablet 1 daily 30 $3,249
Kaletra (lopinavir + ritonavir) 200/50mg tablet 2 twice daily or 4 daily 120 $1,229
Lexiva (fosamprenavir) 700mg tablet 2 twice daily 120 $1,812
Norvir (ritonavir) 100mg tablet 1 daily 30 $309
Odefsey (rilpivirine + tenofovir alafenamide + emtricitabine) 25/25/200mg tablet 1 daily 30 $3,375
Pifeltro (doravirine) 100mg tablet 1 daily 30 $1,656
Prezista (darunavir) 400mg tablet 2 daily 60 $2,028
Prezista (darunavir) 600mg tablet 1 twice daily 60 $2,028
Prezcobix (darunavir + cobicistat) 80/150mg tablet 1 daily 60 $2,317
Retrovir (zidovudine, AZT) 300mg tablet 1 twice daily 60 $54-$365 (generic only) 
Reyataz (atazanavir) 200mg capsule 2 daily 60 $1,756
Reyataz (atazanavir) 300mg capsule 1 daily 30 $1,739
Rukubio (fostemsavir) 600mg tablet 1 twice daily 60 $9,180
Selzentry (maraviroc) 150mg tablet 1 twice daily 60 $1,556
Selzentry (maraviroc) 300mg tablet 1 twice daily 60 $1,556
Stribild (tenofovir + emtricitabine + elvitegravir + cobicistat) 300/200/150/ 150mg tablet 1 daily 30 $3,889
Sustiva (efavirenz) 600mg tablet 1 daily 30 $1,177
Symtuza (darunavir + cobicistat + tenofovir alafenamide + emtricitabine) 80/150/10/200mg tablet 1 daily 30 $4,466
Symfi (efavirenz + tenofovir disoproxil + lamivudine) 600/300/150mg tablet 1 daily 30 $1,961
Symfi Lo (efavirenz + tenofovir disoproxil + lamivudine) 400/300/150mg tablet 1 daily 30 $1,961
Tivicay (dolutegravir) 50mg tablet 1 daily 30 $2,089
Tivicay (dolutegravir) 50mg tablet 1 twice daily 60 $4,178
Triumeq (abacavir + lamivudine + dolutegravir) 600/300/50mg tablet 1 daily 30 $3,467
Trizivir (abacavir + zidovudine + lamivudine) 300/300/100mg tablet 1 twice daily 60 $1,932
Trogarzo (ibalizumab-uiyk) 200mg vial for intravenous infustion 800mg every two weeks 8 vials $10,896
Truvada (tenofovir + emtricitabine) 300/150mg tablet 1 daily 30 $2,011
Tybost (cobicistat) 150mg tablet 1 daily 30 $277
Viramune (nevirapine) 200mg tablet 1 twice daily 60 $1,087
Viramune XR (nevirapine) 400mg tablet 1 daily 30 $1,008
Viread (tenofovir) 300mg tablet 1 daily 30 $1,435
Ziagen (abacavir) 300mg tablet 2 daily 60 $670
Was this page helpful?
Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Mattingly J. Understanding drug pricing. US Pharm. 2012;37(6):40-5.

Additional Reading