Baxdela (Delafloxacin) - Oral


Use of Baxdela (delafloxacin) has been associated with serious side effects, including tendonitis (irritated or torn tendons), tendon rupture, peripheral neuropathy (nerve problems such as burning, numbness, tingling, and pain), effects on the brain (such as mood changes, bad headaches, confusion), and worsening muscle weakness of a rare condition known as myasthenia gravis.

Since you can experience tendon problems several months after treatment, seek medical help immediately if you have pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints or if you are having problems moving/bearing weight on a joint. You should discuss the risks and benefits of this medication with your healthcare provider before you take it, especially if you are at risk of developing any of these side effects.

What Is Baxdela?

Baxdela (delafloxacin) is a prescription-only medication used to treat skin infections caused by bacteria and bacterial community-acquired pneumonia (CAP).

Baxdela belongs to a class of medications known as fluoroquinolone antibiotics. It works by blocking the activity of specific proteins needed for bacteria growth. Baxdela should only be prescribed for infections caused by the bacteria that Baxdela can effectively treat. This helps to reduce the development of antibiotic-resistant bacteria.

Baxdela is available in tablet form to be taken by mouth. It can also be given intravenously (into the vein). However, this article will focus on the oral form of delafloxacin.

Drug Facts

Generic Name: Delafloxacin

Brand Name(s): Baxdela

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Fluoroquinolone antibiotic

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Delafloxacin

Dosage Form(s): Tablet

What Is Baxdela Used For?

The U.S. Food and Drug Administration (FDA) approved Baxdela to treat skin infections and community-acquired pneumonia caused by certain bacteria.

The skin infections Baxdela treats include a broad group of diseases and may present as mild to potentially life-threatening symptoms.

How to Take Baxdela

Take your medication exactly as directed by your healthcare provider. If you don't finish the prescribed course, the bacteria can grow back and become resistant to Baxdela, making it ineffective against that specific bacteria.

Generally, Baxdela is taken every 12 hours, with the duration of treatment depending on the type and severity of the bacterial infection. You should take Baxdela at least two hours before or six hours after antacids containing magnesium or aluminum, Carafate (sucralfate), iron, multivitamins with zinc or iron, or with the medication didanosine (a medication used to treat human immunodeficiency virus (HIV)).


Store Baxdela in a cool, dry place (68 F to 77 F). Do not store it in areas exposed to extremely hot or cold temperatures, like your car or refrigerator. These environments can affect how well your medication works. Do not freeze this medication. Keep it out of reach of children and pets to prevent accidental consumption.

Off-Label Uses

There are currently no off-label uses for Baxdela. It is important to ensure you take Baxdela only as your healthcare provider intends.

How Long Does Baxdela Take to Work?

Baxdela is quickly absorbed, reaching maximum levels in the body one hour after taking it. Baxdela takes about three days to reach a consistent level in the body.

What Are the Side Effects of Baxdela?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your pharmacist or a healthcare provider. You may report side effects to the FDA at or 800-FDA-1088.

Common Side Effects

Common side effects that have been associated with Baxdela use include the following:

Severe Side Effects

Call your healthcare provider immediately if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Tendon rupture and tendonitis
  • Peripheral neuropathy, such as numbness, tingling, pain
  • Effects on the brain, including trouble sleeping, confusion, seeing or hearing things that are not there (hallucinations), seizures, headaches, or mood changes like depression or suicidal thoughts
  • Tears or bursting of a major heart vessel (aorta), which can result in major bleeding. This rare but life-threatening event may happen within two months of taking Baxdela. Adults 65 and older are at the highest risk. Seek immediate medical help if you have sudden chest or back pain or trouble breathing.
  • Severe allergic reaction and hives

Long-Term Side Effects

Talk to your healthcare provider if you are at risk for any of the following:

Report Side Effects

Baxdela may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Baxdela Should I Take?

Drug Content Provided by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For acute bacterial skin and skin structure infections:
      • Adults—450 milligrams (mg) every 12 hours for 5 to 14 days.
      • Children—Use and dose must be determined by your doctor.
    • For community acquired bacterial pneumonia:
      • Adults—450 milligrams (mg) every 12 hours for 5 to 10 days.
      • Children—Use and dose must be determined by your doctor.


Treatment adjustments for Baxdela may be necessary in the following cases.


There is currently limited information on how Baxdela may affect a fetus or pregnant individual. However, animal studies showed some adverse effects, such as toxicity to the pregnant animal and reduced birth weight. Baxdela should only be used during pregnancy if the potential benefits outweigh the risks. 


There is currently no information on the presence of Baxdela in human breast milk, its effects on a breastfed infant, or its effects on milk production.


There is currently no information on the presence of Baxdela in human breast milk, its effects on a breastfed infant, or its effects on milk production.

Adults 65 and Older

Adults 65 and older are at an increased risk of developing a tendon rupture or tendonitis when treated with fluoroquinolone antibiotics. Caution should be used when prescribing Baxdela to people in this age group, especially if they are also taking a class of medications known as corticosteroids.

Kidney Damage

Baxdela is not recommended if you have severe kidney damage (an estimated glomerular filtration rate (eGFR) of 15 milliliters per minute or less) or end-stage kidney disease.

Missed Dose

If you miss a dose, you should take it as soon as possible, up to eight hours before your next dose. If less than eight hours are remaining before your next dose, only take the upcoming scheduled dose and skip the missed one.

Overdose: What Happens If I Take Too Much Baxdela?

Contact your healthcare provider if you take too much Baxdela. You may need medical observation to ensure you are appropriately treated.

What Happens If I Overdose on Baxdela?

If you think you or someone else may have overdosed on Baxdela, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Baxdela, call 911 immediately.


Drug Content Provided by IBM Micromedex®

It is very important that your doctor check your progress at regular visits to make sure it is working properly. Blood and urine tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Delafloxacin may cause inflammation (tendinitis) or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are using the medicine or after you finish using it. The risk of having tendon problems may be increased if you are over 60 years of age, are using steroid medicines (eg, dexamethasone, prednisolone, prednisone, Medrol®), have severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or if you have received an organ transplant (eg, heart, kidney, or lung). Check with your doctor right away if you have sudden pain or swelling in a tendon (eg, ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are unable to bear weight or move the affected area. Refrain from exercise until your doctor says otherwise.

Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

Tell your doctor right away if you have any of the following symptoms while using this medicine: seizures, feeling anxious, confused, or depressed, seeing, hearing, or feeling things that are not there, severe headache, trouble sleeping, or unusual thoughts or behaviors.

Delafloxacin may worsen myasthenia gravis (severe muscle weakness) in people who already have this condition. Talk to your doctor if you have concerns.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you use this medicine.

This medicine may increase your risk for aortic aneurysm (bulge in the wall of the largest artery). Check with your doctor right away if you have sudden chest, stomach, or back pain, trouble breathing, cough, or hoarseness.

Delafloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Delafloxacin may cause some people to become dizzy or lightheaded than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

If you are a diabetic patient taking diabetes medicine by mouth: Delafloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you experience symptoms of low blood sugar, check with your doctor right away.

  • Symptoms of low blood sugar can include: anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty with concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Reasons I Shouldn’t Take Baxdela?

Do not take Baxdela if you:

  • Have a rare condition known as myasthenia gravis
  • Have severe kidney damage or end-stage kidney disease
  • Develop a severe reaction to this medication or any other fluoroquinolones

What Other Medications Interact With Baxdela?

Some medications can stick to Baxdela in the body, reducing its absorption and making it less effective. For this reason, take Baxdela at least two hours before or six hours after certain medications and supplements, such as:

  • Antacids containing aluminum or magnesium
  • Iron
  • Multivitamins with iron or zinc
  • Sucralfate

Tell your healthcare provider about any other medicines you take or plan to take, including over-the-counter (OTC) nonprescription products, vitamins, herbs, supplements, and plant-based medicines.

What Medications Are Similar?

Baxdela belongs to a class of medications known as fluoroquinolone antibiotics. The following drugs are also part of this class:

  • Cipro (ciprofloxacin)
  • Levofloxacin
  • Avelox (moxifloxacin)
  • Ofloxacin

This is a list of other fluoroquinolone antibiotics similar to Baxdela. It is NOT a list of drugs recommended to take with Baxdela. You should not take these drugs together. Talk to your pharmacist or your healthcare provider if you have questions.

Frequently Asked Questions

  • Can Baxdela be used to treat viral infections?

    No, Baxdela is an antibiotic and is only effective against certain bacteria.

  • Can I stop taking Baxdela once I start to feel better?

    No, you should finish all the prescribed medication even if you start feeling better. This is recommended to minimize the risk of bacteria becoming resistant to Baxdela.

  • How much does Baxdela cost?

    How much you pay for your medication will depend on your health insurance. If cost concerns you, talk to your healthcare provider or pharmacist. They can point you to savings cards or other affordability assistance programs for prescription medications.

How Can I Stay Healthy While Taking Baxdela?

It is important to take this medication exactly as directed by your healthcare provider. Do not stop taking the prescribed course early, even if you feel better. Doing so can cause the bacteria to become resistant to the medication, potentially making it ineffective against your infection if you need to take it again.

Along with taking your medication as prescribed, drink water to stay hydrated and get plenty of rest as you recover from your infection.

Pay attention to discomfort or pain, as Baxdela can cause tendon and nerve issues. Stop taking your medication and contact a healthcare provider immediately if you hear a pop or snap in the tendon or develop nerve pain in the hands, arms, legs, or feet.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

The author would like to recognize and thank Cody Ryan Thomas for contributing to this article.

3 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. DailyMed. Label: baxdela- delafloxacin meglumine tablet, baxdela- delafloxacin meglumine injection, powder, lyophilized, for solution.

  2. Saravolatz LD, Stein GE. Delafloxacin: a new anti-methicillin-resistant staphylococcus aureus fluoroquinolone. Clinical Infectious Diseases. 2019;68(6):1058-1062. doi:10.1093/cid/ciy600

  3. Mogle BT. Clinical review of delafloxacin: a novel anionic fluoroquinolone. Journal of Antimicrobial Chemotherapy. 2018;73(6):1439-1451. doi:10.1093/jac/dkx543