Health Benefits of Benfotiamine

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Benfotiamine is a dietary supplement that is a derivative of thiamine (also known as vitamin B1), a B vitamin found in a variety of foods including legumes, nuts and seeds, wheat germ, fortified grain products such as bread, cereal, pasta, rice, and flour, and some meat and fish. Since benfotiamine is fat-soluble and appears to have higher bioavailability and absorption by the body than thiamine, some people use it to raise their thiamine levels and manage certain health conditions.

Indications for Use

Thiamine deficiency is considered rare in the United States. With that being said, people who mainly eat highly refined carbohydrates (such as white rice) or unfortified white flour products or avoid whole grains may be at greater risk for a thiamine deficiency. People with prolonged diarrhea, Crohn's disease, and alcohol dependency may also be at risk. Strenuous exercise and conditions like hyperthyroidism increase the body's demand for thiamine.

Thiamine deficiency requires medical treatment. It is linked to a range of health problems, including nerve, heart, and brain conditions (including a serious condition known as Wernicke's encephalopathy).

Proponents suggest that benfotiamine can shield the body from the harmful effects of advanced glycation end products (AGEs), glycotoxins found in high-fat meats that trigger inflammation and accelerate many aging-related degenerative diseases.

In addition, some believe that benfotiamine in supplement form may aid in the treatment:

Current Evidence

To date, relatively few studies have examined the potential health benefits of taking benfotiamine supplements. Here's a look at some key study findings:


Benfotiamine may be of some benefit to people with diabetes. In a study published in Diabetes Care in 2006, for instance, people with type 2 diabetes consumed 1,050 mg of benfotiamine daily. Participants were given a meal high in AGEs before and after the three day period. Study results showed that benfotiamine appeared to protect against oxidative stress induced by dietary AGEs.

In a 2010 study published in Diabetes Care, researchers investigated the effect of benfotiamine in people with type 2 diabetes and nephropathy. For the study, participants took benfotiamine or a placebo daily for 12 weeks. Results revealed that benfotiamine did not reduce urinary albumin excretion (a test used to monitor kidney disease) or levels of KIM-1 (a marker of kidney injury).

A 12-week study published in PLoS One in 2012 found that benfotiamine didn't significantly affect markers that lead to hyperglycemia-induced vascular complications.

Diabetic Neuropathy

Several small studies suggest that benfotiamine may aid in the treatment of diabetic neuropathy (a condition marked by nerve damage that results from a diabetes-related elevation in blood sugar levels).

A 2012 study from Diabetes Care, however, found that 24 months of treatment with benfotiamine had no significant effects on peripheral nerve function or markers of inflammation in participants with type 1 diabetes.

Alzheimer's Disease

Benfotiamine may have a place in the treatment of Alzheimer's disease, according to a very small 2016 study published in Neuroscience Bulletin. Five participants with mild to moderate Alzheimer's disease took benfotiamine (300 mg daily) for 18 months.

At the study's end, the five participants showed cognitive improvement. The researchers examined three of the participants by PET scan and found an improvement compared to their initial scans.

Side Effects

Although little is known about the safety of taking benfotiamine for an extended period of time, there's some concern that benfotiamine supplements may trigger certain side effects (such as upset stomach, nausea, dizziness, hair loss, weight gain, body odor, and a decrease in blood pressure). Benfotiamine is also known to contain sulfur and should be avoided by anyone with a sulfur sensitivity.

Also, keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.

Due to the paucity of research, the safest dosage of benfotiamine is unknown. If you are considering taking the supplement, speak with your health provider to determine what, if any, amount is right for you.

Where to Buy

Widely available for purchase online, benfotiamine supplements can also be found in many natural-foods stores and in stores specializing in dietary supplements. It does not require a prescription.

A Word From Verywell

While benfotiamine may show promise for conditions such as Alzheimer's disease and diabetic neuropathy, not all studies have found benefits. As such, can't be sure about any of the claims until large-scale clinical trials are conducted.

If you think you may have a thiamine/vitamin B1 deficiency, be sure to speak with your doctor. A simple blood test may be all that is needed to confirm the suspicion.

A number of compounds in food are also being explored as possible AGE inhibitors. These include quercetin (found in capers, onions, cranberries, and apples), catechins (in green tea), and resveratrol (in red grapes, blueberries, red wine, and dark chocolate). Avoiding foods high in AGEs may also help.

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Article Sources
  • Alkhalaf A, Kleefstra N, Groenier KH, et al. Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. PLoS One. 2012;7(7):e40427. 
  • Alkhalaf A, Klooster A, van Oeveren W, et al. A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. Diabetes Care. 2010 Jul;33(7):1598-601. 
  • Fraser DA, Diep LM, Hovden IA, et al. The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care. 2012 May;35(5):1095-7. 
  • Pan X, Chen Z, Fei G, et al.Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease.Neurosci Bull. 2016 Dec;32(6):591-596.