Best At-Home Syphilis Tests

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At-home syphilis tests provide a convenient and discreet option for sexually transmitted infection (STI) testing. However, if your test is positive, the lab is required to report it to the public health department and may ask you to cooperate with partner notification. If you’ve recently had sexual contact with someone who has syphilis or who is unsure of their syphilis status, you should get tested. However, testing too soon might lead to a false negative (i.e., falsely reassuring) test result. Generally, it takes anywhere from a few days to a few weeks for syphilis infections to show up in the blood, so be sure to check with the company offering the test to determine the optimum time to do the test.

The best at-home syphilis tests utilize reputable labs that are accredited by Clinical Laboratory Improvement Amendments (CLIA) or the College of American Pathologists (CAP) to ensure that proper lab protocols are being followed. In addition, they offer post-result support from in-house healthcare providers for those who test positive for syphilis or other STIs.

Best At-Home Syphilis Tests of 2022

Best Overall : My LabBox At Home Syphilis Test


Key Specs
  • Cost: Approximately $89
  • Availability: 49 states
  • Time for Results: 2-5 days
Why We Chose It

The My LabBox At Home Syphilis Test is easy to use, moderately priced, tests only for syphilis, and offers results as quickly as two to five days after receiving your sample.

Pros & Cons
Pros
  • Results in 2-5 days

  • Free 2-day shipping

  • CLIA- and CAP-accredited

Cons
  • More expensive than other syphilis-only tests

  • Not available in New York

Overview

The My LabBox At Home Syphilis Test costs approximately $89 with free two-day shipping. You can pay for the test with your flexible spending account (FSA) or health savings account (HSA) card.

You can order the test online, and when it arrives, you need to activate the kit before collecting your finger-prick blood sample. Once you take the sample and submit it by mail, you can expect to receive your results online within two to five days after the lab receives the sample.

This test checks only for syphilis, and the results are read at a CLIA- and CAP-accredited laboratory. However, it’s not available for residents of New York.

Best for Accuracy : LetsGetChecked Complete 8


LetsGetChecked Complete 8

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Key Specs
  • Cost: Approximately $249
  • Availability: 49 states
  • Time for Results: 2-5 days
Why We Chose It

LetsGetChecked’s Complete 8 test is analyzed by CLIA-certified laboratories, the same caliber of lab used by hospitals and doctors.

Pros & Cons
Pros
  • Results in 2-5 days

  • CLIA-accredited labs

  • Tests for 8 different STIs

Cons
  • More expensive than other STI tests

  • Not available in New York

  • Some complaints of slow results

Overview

The Complete 8 from LetsGetChecked costs approximately $249 with free shipping and can be paid for using your FSA or HSA card. With a subscription, you can save 30% by having a test delivered every three months for about $174.30.

This test checks for chlamydia, gonorrhea, HIV, syphilis, mycoplasma, ureaplasma, trichomoniasis, and Gardnerella.

After ordering the test online and receiving your kit, you need to activate it. Then, collect a finger-prick blood sample and a urine sample. Once you return the sample and it’s received by the lab (all are CLIA-accredited), your results will be ready within two to five days.

If you have a positive result, you can consult with one of LetsGetChecked’s healthcare providers. The company also provides medication for chlamydia, mycoplasma, ureaplasma, trichomoniasis, and Gardnerella.

With the LetsGetChecked app (for iOS or Android), you can order tests, track your tests, and view results. Note that this test isn’t available in New York.

Best for Rapid Results : LetsGetChecked Standard 5


LetsGetChecked Standard 5

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Key Specs
  • Cost: Approximately $149
  • Availability: 49 states
  • Time for Results: 2-5 days
Why We Chose It

LetsGetChecked offers results in as little as two days after receiving your sample.

Pros & Cons
Pros
  • Tests for five common STIs

  • Results in 2-5 days

  • Certain medications provided at no extra cost

Cons
  • More expensive than syphilis-only tests

  • Not available in New York

  • Reviewers say results may be slow in some cases

Overview

LetsGetChecked Standard 5 costs $149 with free shipping, and you can pay for the test using HSA or FSA funds. With a subscription, you'll receive one test every three months at a 30% discount (or about $104.30 per test).

This test checks for chlamydia, gonorrhea, HIV, syphilis, and trichomoniasis, and the kit can be ordered online through the LetsGetChecked website. Once you receive it, you need to activate the test and collect your finger-prick blood sample and urine sample. After you submit the sample, the CLIA-certified lab will analyze your kit and return your results to view online within two to five days.

With a positive result, you can get a phone consultation with one of LetsGetChecked’s healthcare providers. If needed, medication for chlamydia and trichomoniasis are included for no extra fee.

The LetsGetChecked app allows you to order and track tests, view your test results, and more. However, the kit can’t be purchased in New York.

Best on a Budget : EverlyWell Syphilis Test


Key Specs
  • Cost: Approximately $49
  • Availability: 49 states
  • Time for Results: 5-7 business days
Why We Chose It

At approximately $49, the EverlyWell Syphilis Test is the least expensive reputable home syphilis test.

Pros & Cons
Pros
  • Inexpensive

  • CLIA-certified

  • Provider follow up for positive results

Cons
  • Slower results than other companies

  • Not available in New York

  • Can't contact customer service by phone

  • Not for people who've been reinfected with syphilis

Overview

EverlyWell’s Syphilis Test costs about $49 with free shipping and is part of EverlyWell’s membership program, allowing you to get this test or another similarly priced one for about $24.99 per month. You also can use FSA or HSA funds to pay for these tests.

After ordering the kit online and receiving it, you need to activate it before you collect your finger-prick blood sample. Then, submit it to the lab according to the mailing instructions included in the test. Your results should be ready in five to seven business days after being analyzed by EverlyWell’s CLIA-accredited lab.

It's important to note that this test screens for a type of antibody that remains in your system after you've had—and been treated for—syphilis. Therefore, if you've previously had syphilis but are concerned you've been reinfected, this is not the test for you to take. This test is also not available in New York.

Best for Ease of Use : EverlyWell STD Test—Female


Key Specs
  • Cost: Approximately $149
  • Availability: 49 states
  • Time for Results: 5-7 business days
Why We Chose It

EverlyWell’s test kits are easy to use, with clear instructions and straightforward sample collection devices.

Pros & Cons
Pros
  • Tests for seven STIs

  • Targeted tests for men and women

  • CLIA-certified

Cons
  • More expensive than syphilis-only testing

  • Not available in New York

  • No direct phone line for customer service

Overview

The At-Home STD Test from EverlyWell is $149 for men and women, with free shipping on the order. You can choose a semi-annual subscription to save 15%, and the purchase can be made with HSA or FSA funds.

This test—whether you choose the male or female option—measures chlamydia, gonorrhea, hepatitis C, HIV, syphilis, herpes simplex type II, and trichomoniasis.

You can order the test directly from the EverlyWell website. The first step to taking your test is to register the kit; then, collect your samples. Men need to complete a finger-prick blood test and a urine sample, and women must complete a finger-prick blood test and vaginal swab. Once the lab receives your samples in the mail, it will process them and return your results to view online within five to seven business days.

If you test positive for one or more STIs, you will be referred to a physician in the EverlyWell network who can consult with you by phone and potentially provide treatment if appropriate. Note that the test isn’t available in New York.

Best for Multiple STIs : My LabBox Total Box


Key Specs
  • Cost: Approximately $379
  • Availability: 49 states
  • Time for Results: 2-5 days
Why We Chose It

The My LabBox Total Box tests for 10 different STIs, including HIV I and II, hepatitis C, herpes simplex type II, syphilis, genital/throat/rectal chlamydia, genital/throat/rectal gonorrhea, trichomoniasis, Mycoplasma genitalium, and HPV (for an extra fee, for women).

Pros & Cons
Pros
  • Tests for 10 different STIs

  • Results in 2-5 days

  • CLIA- and CAP-accredited

Cons
  • HPV testing costs extra

  • Expensive

  • Shipping and results may be slower than advertised

Overview

The comprehensive Total Box from My LabBox costs $379 at full price with free two-day shipping, but you can save 15% by subscribing and will receive one test every six months. You also can pay for your tests using your FSA or HSA card.

After ordering the test, receiving your kit, and activating it, you need to take four different samples: a finger-prick blood test, urine sample (for men) or vaginal swab (for women), rectal swab, and oral swab. Then, you’ll box your samples and submit them. The lab should have your results ready in two to five days after receiving your samples.

My LabBox works with CLIA- and CA-accredited labs, and if any of your tests come back positive, you’ll have an opportunity to speak with one of their healthcare providers for no extra fee. Note that the kit is not available in New York. 

Final Verdict

Only a small handful of companies offer at-home STI testing from reputable, CLIA- and CAP-approved laboratories. These include Everlywell, LetsGetChecked, and My LabBox. All of these companies offer follow-up with a healthcare provider for positive results, so any one of them is a solid choice. However, My LabBox offers the best at-home syphilis test.

For syphilis testing, the My LabBox At Home Syphilis Test is straightforward, easy to use, and moderately priced—especially when compared to tests that check for multiple STIs. It’s an ideal choice if you are experiencing syphilis symptoms or if you’ve recently had sex with someone who has syphilis.

Compare the Best At-Home Syphilis Test

Company Cost Time for Results Availability (# of states) Data Collection Method
My LabBox At Home Syphilis Test
Best Overall
Approx. $89 2-5 days 49 Finger prick
LetsGetChecked Complete 8
Best for Accuracy
Approx. $249 2-5 days 49 Finger prick, urine sample
LetsGetChecked Standard 5
Best for Rapid Results
Approx. $149 2-5 days 49  Finger prick, urine sample
EverlyWell Syphilis Test
Best on a Budget
Approx. $49 5-7 business days 49 Finger prick
Everlywell STD Test—Female or STD Test—Male
Best for Ease of Use
Approx. $149 5-7 business days 49 Finger prick, urine sample (male), vaginal swab (female)
My LabBox Total Box
Best for Multiple STIs
Approx. $379 2-5 days 49 Finger prick, vaginal swab or urine sample, oral swab, rectal swab

Guide for Choosing the Best At-Home Syphilis Test

Comparing At-Home Syphilis Tests

When choosing which home syphilis test is best for you, consider the following factors:

  • Cost: The price for syphilis and multiple-STI tests can range from roughly $50 to more than $300, depending on how many STIs are tested with the kit.
  • Time for results: For faster results, you may want to go with LetsGetChecked. It offers results in as little as two days.
  • Accuracy: All of the kits and companies mentioned in this list use CLIA- and/or CAP-accredited labs, which helps ensure that proper lab protocols for safety and accuracy are followed.
  • Privacy: Each of these testing companies sends your test in discreet packaging and keeps your personal health data completely private by adhering to HIPAA law.
  • Number of STIs tested: You can test for syphilis alone, but some tests check for up to 10 separate STIs; more STIs included in a test will increase the price.
  • Availability: These tests are not available in New York.

Ordering Your Syphilis Test Kit

After you’ve chosen the test you want to purchase, order the kit directly from the company website. When you receive the kit in the mail, thoroughly read through all of the instructions. Usually, you will need to activate your kit before you collect your sample. After activation, follow the instructions to collect your sample, repackage it, and mail it to the lab. Once you receive your results, you will have an opportunity to discuss them with a healthcare provider and potentially receive a prescription for treatment if you qualify.

Frequently Asked Questions

How Much Does an At-Home Syphilis Test Cost?

Home syphilis tests range from approximately $50 for a test that checks only for syphilis to $300 or more for a test that checks for the presence of several STIs.

How Soon Can An At-Home Syphilis Test Be Taken?

Generally, at-home Syphilis tests can be taken between one to three weeks of suspected infection because it takes time for antibodies to form in high enough concentrations in your body to be detected by at-home tests.

However, because there are different types of syphilis tests on the market, each testing company has different guidelines on the optimum time to do their tests. For example, LetsGetChecked recommends waiting at least 12 weeks before taking the tests it offers. As a result, be sure to check with the company offering the test before taking it.

Is an At-Home Syphilis Test Accurate?

These tests are accurate, as home syphilis tests are typically read by some of the same labs that read samples collected by healthcare providers. To ensure accuracy and that proper protocols are followed, look for a home testing company that employs CLIA- or CAP-accredited labs.

Who Should Take an At-Home Syphilis Test?

Anyone who’s had recent sexual contact with someone who has syphilis, or who is unsure if they have syphilis, should take a syphilis test. Additionally, you should test for syphilis if you’re experiencing any of the following symptoms of syphilis:

  • Round, painless sores (typically in the genital area, but they can appear anywhere)
  • Rough, red, or brown patches on your palms or the soles of your feet
  • Fever
  • Sore throat
  • Headaches
  • Unexplained weight loss or hair loss
  • Unexplained muscle aches or fatigue

Those who may be at a higher risk of contracting syphilis include any sexually active people who:

  • Are biological men who have sex with other biological men
  • Have HIV
  • Have a partner with syphilis

Methodology

After a thorough online search, we uncovered three testing companies that provide home syphilis tests along with other STI testing, utilize CLIA- or CAP-accredited laboratories, and offer treatment options with positive results. Two products from each of these three companies are included here; for each, generally one is a less expensive, less comprehensive test and the other is a more expensive, more comprehensive test.

Edited by Brian Abbott
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2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. Syphilis.

  2. Centers for Disease Control and Prevention. Syphilis - CDC fact sheet.