The 7 Best Over-the-Counter Yeast Infection Medicines to Buy in 2018

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Yeast infections—no one wants one, but most women will get at least one at some point in their lives. Also known as vaginal candidiasis (as they’re caused by an overgrowth of candida yeast), they can cause itching, burning, and a host of other uncomfortable symptoms that can range from mildly annoying to downright debilitating until you get relief.

They can be brought on by anything that changes the acidity of the vagina, including pregnancy, stress, antibiotics, and the use of contraceptives. To get a definitive diagnosis and/or if you frequently get symptoms of a yeast infection, it’s important that you consult with a healthcare professional.

While yeast infections are rarely anything to worry about, they do need to be treated to avoid complications. In some cases, they can be a symptom of a more serious condition.

Fortunately, most vaginal yeast infections can be treated with over-the-counter (OTC) medications. They come in a variety of formulas and forms, including suppositories, tablets, and creams. Here are the top over-the-counter yeast infection medicines to consider, depending on your condition and preferences.

Our Top Picks


Best Overall: Monistat 1-Day Maximum Strength Vaginal Antifungal

When it comes to the treatment of a yeast infection and relief from its accompanying symptoms, many women trust Monistat. This maximum strength formula requires just one day of treatment and promises results fast (in as little as four hours).

The kit has everything you need. It includes an insert to treat the infection, a tube of external cream, and four soothing wipes to help relieve itching and burning while the medication does its job.

It can be used day or night as it uses a “less-mess ovule” that makes it easy to insert and keep the medication (miconazole nitrate) in place, right at the site of the infection.

While some women report burning and increased itching upon initial use of this highly concentrated product (the packaging warns of this), many say it’s the most effective and efficient way to treat yeast infections.


Best Three-Day Treatment: Vagistat 3

For a simple, three-day yeast infection treatment, this one from Vagistat is the choice for many women. The combination pack includes three vaginal suppositories with disposable applicators to treat the infection internally and an external cream to provide relief from itching and burning in the short-term. The main ingredient is miconazole nitrate.

The three-day treatment promises to cure most vaginal yeast infections. Women say they like the slim suppositories and that the side effects (increased itching and burning upon first use) aren’t as bad as with some other products. Overall, most note that it provides the relief they need.


Best Suppositories: NutraBlast Boric Acid Vaginal Suppositories

For a natural option, Boric acid has been found to be particularly effective in treating recurrent yeast infections. And women give this brand of suppositories that contain it top marks.

Each capsule contains 600 milligrams of boric acid, which is thought to support a woman’s pH balance and overall vaginal health. To use it, insert one capsule into the vagina (with or without an applicator) at bedtime for seven days.

While acid may sound a bit harsh, this particular type of acid is generally regarded as safe with few, if any, side effects—and women say it works well. “I struggle with chronic yeast infections and this seems to be the only remedy that works for me,” one reviewer wrote on Amazon.

Boric acid is, however, considered an alternative treatment. So, it’s a good idea to consult with your doctor before using it.


Best Prevention Pills: Yeastgard Advanced Homeopathic Capsules

If you’d rather pop a pill than mess with creams and inserts, consider these capsules from Yeast Gard. They promise homeopathic relief from yeast infection symptoms and may even stave ​off future infections.

The capsules contain a mix of ingredients in a probiotic base and are intended to help the body rebalance its yeast on its own and heal. They can be used in conjunction with the company’s other products that deliver yeast infection treatment via suppositories or douche.

Because it’s a homeopathic product, its effectiveness hasn’t been evaluated by the U.S. Food and Drug Administration. Yet, plenty of women swear by these capsules for preventing recurring yeast infections without using drugs. As always, please consult a medical professional before starting a supplement regime. 


Best Budget: Taro Clotrimazole 7 Vaginal Cream


Courtesy of Amazon

While it doesn’t have the name brand recognition, this seven-day Taro clotrimazole cream gets high marks for effectively treating vaginal yeast infections. It comes with seven days of cream you insert via an applicator as well as an external cream to relieve itching and external irritation.

Similar to other products that contain clotrimazole, this one offers significant savings. Women say it works well, doesn't burn, and is as good, if not better, than similar, higher-priced products.

Some do note, however, that it’s a bit more tedious to use than products with multiple disposable applicators since it only comes with one that you have to wash after each use.


Best Itch Relief: Vagisil Maximum Strength Instant Anti-Itch Vaginal Crème

While this cream from Vagisil won’t actually treat a yeast infection (you’ll need to find an additional method for that), it does promise to deliver immediate relief from the itching and burning that typically comes along with one.

Its hypoallergenic formula is designed to help relieve the most painful burning and itching quickly without irritation. It can also be used for vaginal itching due to other causes, so it’s a good one to have on hand.  

The cream, which you apply with your finger, contains two external analgesics (benzocaine and resorcinol) and a blend of Vitamins A, D, E, and aloe.

Customers say it provides effective, long-lasting relief. They also like that this particular pack comes in four 1-ounce tubes, so it’s convenient to store in your purse, makeup bag, and other places you might need it.


Best for Use During Pregnancy: Monistat 7-Day Vaginal Antifungal Pack


Courtesy of Target

While some prescription treatments should be avoided in pregnancy, experts say the active ingredient in Monistat (miconazole nitrate) is safe for mom and baby, with no risk of birth defects or other complications. It comes with seven disposable applicators to be used once a night at bedtime for a week.

Doctors say that longer treatments such as this are better during pregnancy than more concentrated formulas that offer treatment in just one or several days. This seven-day treatment provides the least concentrated dose of medication, but women say it’s still effective and doesn’t come with the burning and itching of stronger formulas.

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