Can Headaches Be a Symptom of Breast Cancer?

Headaches are common, albeit unpleasant, experiences. They are not generally a symptom of breast cancer unless the cancer is advanced and spreads to the brain. Individuals diagnosed with breast cancer may also experience headaches related to treatment.

This article explores the possible causes and management options for headaches associated with advanced breast cancer or breast cancer treatments.

Person with breast cancer and their spouse describe headache to a healthcare provider

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What Are Headaches?

A headache is a pain or discomfort in the head or face. Headaches vary in severity, location, and quality. They are generally classified as primary or secondary.

Primary headaches exist independently, whereas secondary headaches arise from an underlying condition, such as a health problem or medication.

Primary Headaches

Most primary headaches fall into these three categories:

  • Tension-type headaches feel like a tightening or a sensation of pressure around the head. The pain is mild to moderate in intensity and can be associated with shoulder and upper back stiffness.
  • Migraine headaches feel like throbbing pain on one or both sides of the head. The pain is moderate to severe in intensity and may be associated with nausea, vomiting, and sensitivity to light, sound, and smell.
  • Cluster headaches feel like an excruciatingly sharp or stabbing pain on one side of the head. These headaches are associated with restlessness, red or watery eyes, stuffy nose, or forehead sweating.

Secondary Headaches

Secondary headaches vary based on their underlying origin. They may arise from a brain infection, tumor, injury, or other problem with the nerves or blood vessels within your head or neck.

Are Headaches a Symptom of Breast Cancer?

Headache is not a symptom of breast cancer, but it might occur if cancer spreads to the brain. Treatments used in breast cancer may also cause headaches as a side effect. In both instances, such a headache is considered a secondary headache.

Advanced Breast Cancer

Breast cancer develops when abnormal breast cells grow uncontrollably within the breast lobules (glands that make milk), ducts (tubes that carry milk to the nipple), or fatty tissue.

Advanced breast cancer, also called metastatic, or stage 4, breast cancer, occurs when breast cancer cells travel (metastasize) beyond the breast to other organs within the body. The brain is one of the most common sites of breast cancer metastasis, along with the bones, liver, and lungs.

In patients with brain metastasis, headache is often the first symptom. A headache from brain metastasis is often described as being worse in the morning or aggravated by the Valsalva maneuver (like coughing or bearing down during a bowel movement).

However, recent research suggests that this "classic" headache is uncommon. Instead, headaches from brain metastasis are variable. They can resemble tension-type headaches, migraine headaches, or a combination of these.

In rare instances, hydrocephalus (a buildup of fluid in the brain) may occur if the breast cancer has spread to the meninges (the membranes surrounding the brain).

What Is Hydrocephalus?

Hydrocephalus increases cerebrospinal fluid (CSF) pressure in the brain, causing severe headaches and other symptoms like blurry vision or vomiting. CSF is fluid that surrounds and cushions the brain and spinal cord.

Breast Cancer Treatments

Various therapies used to treat breast cancer may cause headaches as a side effect.

Examples of such treatments include:

  • Chemotherapy: These drugs kill fast-growing cancer cells. Some, like Ixempra (ixabepilone), can cause headaches as a side effect.
  • Hormone therapyThese drugs block the body's ability to make estrogen or interfere with estrogen's effect on breast cancer cells. The injectable hormone therapy Faslodex (fulvestrant) may cause headaches.
  • Immunotherapy: These drugs use a person's immune system to recognize and kill cancer cells. Headache is a side effect of Keytruda (pembrolizumab), an immunotherapy drug used to treat triple-negative breast cancer.

Treatment and Management of Headaches

After determining the cause of your headache, your healthcare provider can help you formulate a safe and effective treatment plan.

Advanced Breast Cancer

If your headache is related to breast cancer metastasizing to the brain, treatment options may include surgery, radiation, or medication. Steroids (anti-inflammatory drugs) can also help reduce brain swelling from cancer buildup.

With a headache from hydrocephalus, a shunt (a tube to drain fluid) may be placed to relieve the pressure.

Breast Cancer Treatments

Your healthcare provider may switch your medication if you develop debilitating headaches related to breast cancer treatment. Alternatively, if your headache resembles a primary headache disorder, your healthcare provider will treat it as such.

For example, if the headache feels like a tension-type headache, simple home remedies, such as applying heat or ice, massage, eating a healthy snack, or taking a nap, may relieve it.

If these remedies don't help, your healthcare provider may suggest an over-the-counter (OTC) drug, such as Tylenol (acetaminophen) or a nonsteroidal anti-inflammatory drugs (NSAIDs) like Aleve (naproxen sodium), Motrin Advil (ibuprofen), or Bayer, Bufferin, or Ecotrin (aspirin).

Likewise, if your headache resembles a migraine, your provider may recommend an OTC NSAID or a prescription triptan, like Imitrex (sumatriptan). Napping in a dark, quiet room or placing a cold pack on the area of head pain can also be helpful.

Talk With Your Healthcare Provider

Speak with your healthcare provider before taking any medication, including OTC drugs. In addition to ensuring it's safe for you to take, you will want to avoid complications like medication overuse headaches. These are rebound headaches that occur when painkillers are used too frequently.

When to See Your Healthcare Provider

Most headaches are not dangerous, although there are situations in which your headache warrants prompt or emergent medical care.

See your healthcare provider if:

  • Your headache pattern is changing or affecting your daily routine.
  • You have a new headache and are over age 65, are pregnant or just gave birth, or have a history of cancer or a weakened immune system.
  • Your headache is triggered by sneezing, coughing, or exercising.
  • You are having headaches and frequently taking pain-relieving medication.

Go to your nearest emergency room if:

  • Your headache is severe, starts abruptly, and/or is the "worst headache of your life."
  • Your headache is severe and associated with a painful red eye, high fever, stiff neck, or stroke symptoms (e.g., vision changes, weakness, or numbness).
  • Your headache occurs after a head injury.


Nearly everyone experiences a headache at some point. They are usually primary headaches and not a symptom of breast cancer unless cancer cells have traveled to the brain. Surgery, radiation, medication, shunt placement, or a combination of these are used to treat breast cancer that has spread to the brain.

Drugs used to treat breast cancer may also cause a headache as a side effect. These headaches are typically treated with OTC or prescription headache painkillers. Your healthcare provider may consider altering your breast cancer medication if you have disabling headaches.

A Word From Verywell

It's important to remember that headaches are extremely common experiences. Even if a person with breast cancer develops a headache, it's still most likely due to typical causes like stress, lack of sleep, or skipping a meal.

While a healthcare provider will carefully evaluate any headache in a person with breast cancer, a cancer metastasis diagnosis will be more strongly suspected if warning signs are also present. Such warning signs include an abnormal neurological examination or a change in the prior headache pattern.

Frequently Asked Questions

  • What is the most common type of headache?

    Tension-type headaches are the most common type of headache. They typically cause a dull, tightening sensation felt all over the head. The pain is usually mild to moderate in intensity.

  • Can cancer cause headaches?

    Cancer may cause headaches if the cancer cells travel to the brain. Lung cancer followed by breast cancer is the most common cancer that spreads to the brain.

  • Besides a headache, what other symptoms may occur with metastatic breast cancer to the brain?

    Other symptoms of brain metastasis may include weakness or numbness on one side of the body, vision disturbance, seizures, vomiting, and confusion.

  • Can headache be a side effect of hormone therapy for breast cancer?

    Yes. Certain hormone therapies, like tamoxifen and Faslodex (fulvestrant), may cause headaches as a side effect of treatment.

12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Rizzoli P, Mullally W. HeadacheAm J Med. 2018;131(1):17-24. doi:10.1016/j.amjmed.2017.09.005

  2. American Association of Neurological Surgeons. Metastatic brain tumors.

  3. Palmieri A, Valentinis L, Zanchin G. Update on headache and brain tumors. Cephalalgia. 2021;41(4):431-437. doi:10.1177/0333102420974351

  4. Lamba N, Fick T, Nandoe Tewarie R, Broekman ML. Management of hydrocephalus in patients with leptomeningeal metastases: an ethical approach to decision-making. J Neurooncol. 2018;140(1):5-13. doi:10.1007/s11060-018-2949-7

  5. National Institute of Neurological Disorders and Stroke. Hydrocephalus fact sheet.

  6. Headaches.

  7. Lee CI, Goodwin A, Wilcken N. Fulvestrant for hormone-sensitive metastatic breast cancerCochrane Database Syst Rev. 2017;1(1):CD011093. doi:10.1002/14651858.CD011093.pub2

  8. Brain metastasis.

  9. Sprouse-blum AS, Gabriel AK, Brown JP, Yee MH. Randomized controlled trial: targeted neck cooling in the treatment of the migraine patientHawaii J Med Public Health. 2013;72(7):237-41

  10. Phu Do T, Remmers A, Schytz HW et al. Red and orange flags for secondary headaches in clinical practice: SNNOOP10 listNeurology. 2019;92(3):134-144. doi:10.1212/WNL.0000000000006697

  11. Watase C, Shiino S, Shimoi T, et al. Breast cancer brain metastasis-overview of disease state, Treatment options and future perspectives. Cancers (Basel). 2021;13(5):1078. doi:10.3390/cancers13051078

  12. Cacho-Díaz B, Spínola-Maroño H, Arrieta VA, et al. Diagnosis of brain metastases in breast cancer patients resulting from neurological symptoms. Clin Neurol Neurosurg. 2018;173:61-64. doi:10.1016/j.clineuro.2018.08.002

By Colleen Doherty, MD
 Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis.