Breast Cancer Treatment During Pregnancy

A different approach to treatment

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Treating breast cancer during pregnancy can be frightening. The health of the woman and the baby both have to be taken into consideration.

Still, that doesn't mean you don't have options. Surgery, chemotherapy, radiation, and hormone therapy may all have their place in your treatment plan, but the timing of certain treatments might have to change. It all depends on the type and location of the cancer and how far into your pregnancy it's diagnosed.


Surgery during pregnancy is considered safe for the baby, so it's usually the first treatment option for pregnant women with breast cancer, especially in the early stages of cancer.

However, radiation poses too big a risk to your baby, so it shouldn't be done during pregnancy. Breast-conserving surgery, such as lumpectomy and partial mastectomy, may require radiation treatment as a follow-up. However, that can't be done during pregnancy. Radiation treatments are given in high doses that can damage a baby at any stage of a pregnancy, even if a lead shield is used.

Mastectomy, on the other hand, doesn't require radiation afterward. Because of that, a mastectomy and lymph node removal is the most common breast cancer surgery for pregnant women, especially during the first trimester.

Lumpectomy may be performed later in pregnancy and radiation treatments delayed until after childbirth.

General anesthesia is part of whatever type of breast cancer surgery you and your doctor choose. Anesthesia can pose some risks to the baby, so your doctors will need to work together to determine the best time during your pregnancy to schedule the surgery.


Chemotherapy can harm a baby's developing organs, so it's not used during the first trimester. It's considered safer in the second and third trimesters.

The drugs used for chemo during pregnancy will depend on the trimester you are in when your treatment begins. Taking certain drugs is riskier during certain trimesters than others.

Anthracycline drugs, including Adriamycin (doxorubicin), are the most commonly used during pregnancy, often combined with Cytoxan (cyclophosphamide). Many studies on FAC chemotherapy—which combines the two drugs above with Adrucil (fluorouracil)—have shown that this treatment is safe for your baby. It's rare for miscarriage, premature birth, stillbirths, or birth defects to be associated with FAC treatment.

Chemotherapy can affect your future fertility. Be sure to discuss this possibility with your doctor if you want to have more children.

Taxane regimens aren't generally used during pregnancy. These drugs include Taxol (paclitaxel) and Taxotere (docetaxel). Methotrexate is known to cause miscarriage and birth defects and thus should never be used during pregnancy.

Guard Your Immune System

Chemo lowers your white blood cell count and leaves you and your baby more vulnerable to infection during treatment. Not every baby's immune system will be affected during chemo, but if it is compromised and remains low after birth, be sure to get treatment.

Many doctors believe it's safe during pregnancy to provide injections of drugs that raise the white blood cell count, such as Neupogen (filgrastim) or Neulasta (pegfilgrastim).

Radiation Therapy After Pregnancy

Radiation helps kill any cancer cells that may still be present in your breast, which can prevent a recurrence. However, it can cause miscarriage, birth defects, or slow growth, so this therapy is used only after you give birth.

Not much research has been done on the effect of breast radiation or brachytherapy (very localized radiation) on breasts that have changed as a result of pregnancy. Therefore, we don't know if delayed treatment will be as effective after giving birth as it would otherwise.

In general, though, research shows that women who delay radiation due to pregnancy don't have worse outcomes than women who get the treatment right away.

Hormonal Therapy After Pregnancy

Tamoxifen is a hormonal therapy that blocks estrogen from breast tissues. It is usually given to women with estrogen-receptor positive breast cancer.

However, it is dangerous to take during pregnancy. Hormone therapy can be given after your baby’s birth to lower your risk of recurrence.

Hard Choices

At a time when you may be very focused on the new life within you, you may be asked to make some hard, personal decisions. While it's far less common than it used to be, you may be asked to consider ending the pregnancy. It's more common when an aggressive type of cancer is diagnosed early in pregnancy.

It's important to note that research has not shown that termination has a beneficial effect on breast cancer outcome, and it is not usually considered as a therapeutic option.

However, if your cancer is aggressive, was diagnosed late, and you're in need of high-dose chemo and radiation, you might have to discuss termination of your pregnancy in order to allow for proper treatment. Another option could be early delivery of your baby if you are at a late stage of pregnancy and the baby's chance of survival is good.

Talk with your family, oncologist, and obstetrician to fully consider all your options.

Breast Cancer Doctor Discussion Guide

Get our printable guide for your next doctor's appointment to help you ask the right questions.

Doctor Discussion Guide Woman

A Word From Verywell

You're being asked to make incredibly difficult decisions, weighing your treatment needs against the risks to your baby. Along with leaning on friends and family, you may want to consider seeing a counselor to help you get through this process emotionally.

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