Heart Health High Cholesterol Nutrition The Health Benefits of Artichoke Leaf Extract Scientists Examine the Link Between Artichokes and Cholesterol By Jennifer Moll, PharmD facebook Jennifer Moll, MS, PharmD, is a pharmacist actively involved in educating patients about the importance of heart disease prevention. Learn about our editorial process Jennifer Moll, PharmD Medically reviewed by Medically reviewed by Richard N. Fogoros, MD on July 18, 2019 facebook linkedin Richard N. Fogoros, MD, is a retired professor of medicine and board-certified internal medicine physician and cardiologist. Learn about our Medical Review Board Richard N. Fogoros, MD Updated on November 12, 2019 Print Artichoke leaf extract is derived from artichokes (Cynara scolymus). This plant belongs to the daisy family and is native to areas such as southern Europe and northern Africa. Artichokes are a delicious accompaniment to many dishes, and its leaves have been traditionally used to treat ailments like jaundice, acid reflux, and various liver disorders. Research studies are showing that artichoke may have another niche: lowering cholesterol. Funwithfood / Getty Images Health Benefits Artichoke extract is sometimes used to treat a variety of health conditions. For example, some consumers use the extract to treat hangovers, high blood pressure, anemia, arthritis, kidney problems, liver problems, snake bites, water retention, and other concerns. There is not enough evidence to support the use of artichoke leaf extract for these health benefits. There is research, however, to support the use of artichoke leaf extract to treat indigestion and high cholesterol with studies about cholesterol gaining interest. High Cholesterol Unfortunately, the studies are mixed regarding the use of artichokes in lowering cholesterol. Most only involve examining the effects of artichoke leaf extract, which is also widely available as a supplement. The manner by which artichokes lower cholesterol is not fully known. It is thought that artichokes may indirectly interact with the same protein that statins interact with to lower cholesterol. Called HMG-CoA reductase, this enzyme plays an important role in the making of cholesterol. Artichokes also contain antioxidants, such as flavonoids. These chemicals are also in a variety of other, colorful vegetables and fruits and are thought to play a role in lowering the oxidation of LDL, which contributes to atherosclerosis. Possible Side Effects Artichokes are likely safe when consumed as food and possibly safe when taken by mouth as medicine. It has been used safely in research for up to 23 months. During research studies, the only significant side effects noted were hunger, flatulence, and weakness. Other possible side effects include upset stomach and diarrhea. Artichoke and artichoke supplements might also cause allergic reactions in people who are allergic to plants such as marigolds, daisies, and other similar herbs. Dosage and Preparation There is not enough scientific data to provide a recommended dose of artichoke leaf extract. Amounts used in research varies. Suggested doses range from 320 to 1,800 milligrams per day. The appropriate dose for you may depend on factors including your age, gender, and medical history. Speak to your healthcare provider to get personalized advice. What to Look For Artichokes are a healthy alternative to consuming other high-fat foods, but they should not be solely relied upon to lower your cholesterol and triglyceride levels. Although there are also several forms of artichoke extract supplements commercially available, they might not lend the other nutrients that an actual artichoke can contribute to your diet. Because artichoke leaf extract supplements may interact with other medical conditions that you have or medications you are taking, you should talk to your healthcare provider before including them in your health regimen. There are plenty of ways to include artichokes in your cholesterol-lowering diet. Artichokes can be lightly sautéed, roasted, grilled, or consumed raw. Just be careful not to cook your artichokes in heavy fats or fry them - this can add more calories and saturated fat to your dish. Was this page helpful? Thanks for your feedback! Looking to start a diet to better manage your cholesterol? Changing lifelong eating habits can be scary at first, but our guide will make it easier. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Rondanelli M, Giacosa A, Opizzi A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7-15. doi:10.3109/09637486.2012.700920 Standard N. Natural Standard Herb & Supplement Guide - E-Book An Evidence-Based Reference. St Louis: Elsevier Health Sciences; 2010.