The Health Benefits of Artichoke Leaf Extract

Scientists Examine the Link Between Artichokes and Cholesterol

Artichoke leaf extract is derived from artichokes (Cynara scolymus). This plant belongs to the daisy family and is native to areas such as southern Europe and northern Africa.

Artichokes are a delicious accompaniment to many dishes, and its leaves have been traditionally used to treat ailments like jaundice, acid reflux, and various liver disorders. Research studies are showing that artichoke may have another niche: lowering cholesterol.

Artichoke in Baskets, Fresh Spring Vegetables at Farmer's Market
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Health Benefits

Artichoke extract is sometimes used to treat a variety of health conditions. For example, some consumers use the extract to treat hangovers, high blood pressure, anemia, arthritis, kidney problems, liver problems, snake bites, water retention, and other concerns. There is not enough evidence to support the use of artichoke leaf extract for these health benefits.

There is research, however, to support the use of artichoke leaf extract to treat indigestion and high cholesterol with studies about cholesterol gaining interest.

High Cholesterol

Unfortunately, the studies are mixed regarding the use of artichokes in lowering cholesterol. Most only involve examining the effects of artichoke leaf extract, which is also widely available as a supplement.

The manner by which artichokes lower cholesterol is not fully known. It is thought that artichokes may indirectly interact with the same protein that statins interact with to lower cholesterol. Called HMG-CoA reductase, this enzyme plays an important role in the making of cholesterol.

Artichokes also contain antioxidants, such as flavonoids. These chemicals are also in a variety of other, colorful vegetables and fruits and are thought to play a role in lowering the oxidation of LDL, which contributes to atherosclerosis.

Possible Side Effects

Artichokes are likely safe when consumed as food and possibly safe when taken by mouth as medicine. It has been used safely in research for up to 23 months.

During research studies, the only significant side effects noted were hunger, flatulence, and weakness. Other possible side effects include upset stomach and diarrhea.

Artichoke and artichoke supplements might also cause allergic reactions in people who are allergic to plants such as marigolds, daisies, and other similar herbs.

Dosage and Preparation

There is not enough scientific data to provide a recommended dose of artichoke leaf extract. Amounts used in research varies. Suggested doses range from 320 to 1,800 milligrams per day.

The appropriate dose for you may depend on factors including your age, gender, and medical history. Speak to your healthcare provider to get personalized advice.

What to Look For

Artichokes are a healthy alternative to consuming other high-fat foods, but they should not be solely relied upon to lower your cholesterol and triglyceride levels.

Although there are also several forms of artichoke extract supplements commercially available, they might not lend the other nutrients that an actual artichoke can contribute to your diet. Because artichoke leaf extract supplements may interact with other medical conditions that you have or medications you are taking, you should talk to your healthcare provider before including them in your health regimen.

There are plenty of ways to include artichokes in your cholesterol-lowering diet. Artichokes can be lightly sautéed, roasted, grilled, or consumed raw. Just be careful not to cook your artichokes in heavy fats or fry them - this can add more calories and saturated fat to your dish.

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2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Rondanelli M, Giacosa A, Opizzi A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7-15. doi:10.3109/09637486.2012.700920

  2. Standard N. Natural Standard Herb & Supplement Guide - E-Book An Evidence-Based Reference. St Louis: Elsevier Health Sciences; 2010.