Can I Take Aspirin and Ibuprofen Together?

Person holding two pills and a glass of water.

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Aspirin and ibuprofen are not the same medication. You should know how each medication works before taking aspirin and ibuprofen together. 

This article will go over whether it is safe to take aspirin and ibuprofen at the same time, how to safely take these medications, and what you can take besides aspirin and ibuprofen to manage your symptoms. 

Is It Safe to Take Aspirin and Ibuprofen Together?

Aspirin is a blood thinner. Your healthcare provider may want you to take it to help with conditions that involve blood clots (which happen when the blood clumps together). For example, taking aspirin may help protect some people against heart attacks and strokes.

Ibuprofen (sold under the brand names Motrin and Advil) is a non-steroidal anti-inflammatory drug (NSAID) that helps with pain.

However, ibuprofen can change the blood-thinning (or anti-clotting) effect of low-dose aspirin.

Here are a few key points to know about taking aspirin and ibuprofen at the same time. 

  • If you take ibuprofen occasionally, there's not much risk that it will interfere with the effect of low-dose aspirin.
  • If you need just one dose of ibuprofen, take it 8 hours before or 30 minutes after taking a regular, non-coated, and not extended-release, low-dose aspirin.
  • If you need to take ibuprofen more often, talk to your provider about medication alternatives. You should not take another NSAID unless your provider tells you to because these drugs can change the effect of low-dose aspirin as how ibuprofen can.

How to Safely Take Ibuprofen and Aspirin Together

In general, the Food and Drug Administration (FDA) recommends that you wait at least 8 hours after you take ibuprofen to take aspirin. If you take aspirin first, wait at least 30 minutes before you take a dose of ibuprofen.

It’s important to know that the FDA recommendations for mixing ibuprofen and aspirin only focus on low-dose aspirin.

Ibuprofen's ability to affect the blood-thinning effects of coated aspirin or larger doses of aspirin is not known.

To be on the safe side, always talk to your provider or a pharmacist before taking any OTC pain medications if you're already taking aspirin.

What If I Mix Ibuprofen and Aspirin by Accident?

If you think you have mixed any medications that should not be used together or have taken a dose of a medication that is too much, call Poison Control, your provider, or your pharmacist.

What Happens if You Take Aspirin Daily?

Healthcare providers may recommend a daily low dose of aspirin to help reduce the risk of certain heart conditions. However, aspirin can cause side effects like stomach upset and bleeding in the body that can be serious.

Daily aspirin is sometimes recommended for people who are between the ages of 40 and 70 years old who:

  • Do not currently have heart conditions
  • Are at risk for developing a heart condition in the next 10 years
  • Are not at risk for bleeding

What Can I Take Besides Ibuprofen and Aspirin?

There are other OTC painkillers you might be able to take besides ibuprofen and/or aspirin. One of the most common is acetaminophen, which is sold under the brand name Tylenol. 

You should ask your provider what they recommend as an alternative, as well as find out what dose and dosing schedule they recommend to treat your symptoms. 

Can I Mix Ibuprofen and Acetaminophen?

Ibuprofen and acetaminophen (also sold under the brand name Tylenol) can be mixed.

One study showed that when ibuprofen and acetaminophen are mixed in a formula called Maxigesic, it provided better pain relief for people who had oral surgery compared to using either ibuprofen or acetaminophen alone.

If you need more pain control than you can get from OTC products, talk to your provider. They might be able to offer a specific recommendation or prescribe something stronger.


Your provider may want you to take aspirin every day to prevent certain conditions related to your blood clotting. However, keep in mind that if you take ibuprofen at the same time, it can affect aspirin’s ability to do its job to protect you from blood clotting problems.

Ask your provider or pharmacist about alternative medications. For example, you might be able to take Tylenol with ibuprofen to manage your symptoms.

6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. U.S. Food and Drug Administration. Concomitant use of ibuprofen and aspirin: potential for attenuation of the antiplatelet effect of aspirin.

  3. Angiolillo DJ, Weisman SM. Clinical pharmacology and cardiovascular safety of naproxen. Am J Cardiovasc Drugs. 2017;17(2):97-107.  doi:10.1007/s40256-016-0200-5

  4. American College of Cardiology. Taking aspirin: common questions.

  5. U.S. Preventative Services Task Force. Aspirin use to prevent cardiovascular disease: preventative medication.

  6. Merry AF, Gibbs RD, Edwards J, et al. Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. Br J Anaesth. 2010;104(1):80-8.  doi:10.1093/bja/aep338

By Michael Bihari, MD
Michael Bihari, MD, is a board-certified pediatrician, health educator, and medical writer, and president emeritus of the Community Health Center of Cape Cod.