Can Natural Remedies Ease Interstitial Cystitis?

Some studies suggest that certain alternative treatments may benefit people with interstitial cystitis, a chronic condition marked by inflammation in the tissues of the bladder wall. Sometimes referred to as "painful bladder syndrome," interstitial cystitis often causes pain and/or uncomfortable pressure in the bladder. While there's no cure for interstitial cystitis, a number of therapeutic approaches (including medication and lifestyle changes, in addition to alternative treatments) may help ease symptoms.

Woman with interstitial cystitis pain
Alberto Pomares / E+ / Getty Images

Natural Remedies Researched 

To date, few studies have examined the use of alternative treatments for interstitial cystitis. However, preliminary findings suggest that these alternative treatments might be of some benefit for people with interstitial cystitis:


Melatonin, an antioxidant substance available in supplement form, was found to protect the bladder lining from irritants in a 2003 study on rats. According to the study's authors, this finding suggests that melatonin holds promise as an alternative treatment for interstitial cystitis.


In a 2001 trial involving 22 interstitial cystitis patients, researchers found that four weeks of twice-daily treatment with 500 mg of quercetin led to a significant improvement in interstitial cystitis symptoms. Quercetin, which is an antioxidant found naturally in foods like black tea and berries, also produced no side effects in the study participants. Quercetin has also been studied for men with chronic pelvic pain or prostatitis (inflammation of the prostate).


The safety and adverse effects of supplements are poorly understood. Supplements haven't been tested for safety and due to the fact that dietary supplements are largely unregulated, the content of some products may differ from what is specified on the product label. Also keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.

Treatment for Interstitial Cystitis

Although the cause of interstitial cystitis is unknown, it's thought that the condition may result from defects in the protective lining of the bladder, the immune system, and/or the pelvic nerves. Women and people with other chronic pain conditions (such as irritable bowel syndrome and fibromyalgia) appear to be at an increased risk for interstitial cystitis.

Because the cause of interstitial cystitis is unknown, most standard treatments strive to alleviate symptoms. Oral medications, for instance, may help reduce pain, relax the bladder, and decrease urinary frequency, while stretching the bladder (in a medical procedure called "bladder distention") may improve a number of interstitial cystitis symptoms.

Healthcare providers often recommend certain lifestyle changes, such as lowering your intake of possible bladder irritants (including caffeine and foods or beverages with a high concentration of vitamin C), wearing loose clothing, practicing stress management techniques, and quitting smoking, for further help in managing interstitial cystitis.

Using Alternative Medicine for Interstitial Cystitis

Due to the lack of supporting research, it's too soon to recommend alternative medicine for interstitial cystitis. If you experience any symptoms of interstitial cystitis (such as pelvic pain and a persistent urge to urinate), it's important to talk to your healthcare provider before using any type of alternative treatment.

Keep in mind that alternative medicine should not be used as a substitute for standard care. Self-treating a condition and avoiding or delaying standard care may have serious consequences. 

4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Tordjman S, Chokron S, Delorme R, et al. Melatonin: Pharmacology, Functions and Therapeutic BenefitsCurr Neuropharmacol. 2017;15(3):434–443. doi:10.2174/1570159X14666161228122115

  2. Li Y, Yao J, Han C, et al. Quercetin, Inflammation and ImmunityNutrients. 2016;8(3):167. doi:10.3390/nu8030167

  3. Shoskes DA, Zeitlin SI, Shahed A, Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trialUrology. 1999;54(6):960-963. doi:10.1016/s0090-4295(99)00358-1

  4. American Urological Association. Diagnosis and Treatment Interstitial Cystitis/Bladder Pain Syndrome (2014)

Additional Reading

By Cathy Wong
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.