Can Capsaicin Cream Ease Your Pain?

Health Benefits, Uses, Side Effects, Tips & More

Red chili peppers
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If you live with pain, you know all too well how difficult it can be to manage. You may have heard of capsaicin (the active ingredient in chili peppers). When applied topically in the form of a cream, ointment, gel, lotion, or transdermal skin patch, capsaicin is thought to provide pain relief by temporarily changing the way your body processes pain.

Why Do People Use Capsaicin Cream?

When applied to the skin, capsaicin appears to cause local densensitization after a period of initial irritation.

Capsaicin cream is said to relieve pain resulting from a wide range of conditions, including:

  • Back pain
  • Gout
  • Headaches, such as cluster headaches
  • Joint pain, such as knee pain
  • Neuropathy
  • Osteoarthritis
  • Postherpetic neuralgia
  • Rheumatoid arthritis
  • Sciatica
  • Shingles
  • Tendonitis, such as tennis elbow
  • Trigeminal neuralgia

The Benefits of Topical Capsaicin: Does It Work?

A number of preliminary studies suggest that topical capsaicin may offer a variety of health benefits. Here's a look at findings from the available research:

1) Chronic Neuropathic Pain

In a review published in the Cochrane Database of Systematic Reviews in 2017, researchers sized up eight previously published clinical trials (involving 2488 participants) examining the effectiveness of a high-concentration capsaicin patch in people with chronic neuropathic pain (pain caused by damage to nerves, either from an injury or disease) from the following conditions:

  • Postherpetic neuralgia
  • HIV-neuropathy
  • Peripheral diabetic neuropathy

The report revealed that a small number of participants who had the patch reported that they were "much" or "very much" improved after using the capsaicin patch.

A previous review concluded that the data on low-concentration capsaicin patches (containing less than 1 percent capsaicin) was insufficient to make any treatment recommendations and suggested that it was not effective.

A high concentration (8 percent) capsaicin patch is approved by the U.S. Food and Drug Administration (FDA) for the management of postherpetic neuralgia pain. Due to the initial pain and burning sensation, the patch is applied under local anesthetic by a medical professional in a clinic or hospital setting.

2) Osteoarthritis

In a report published in Osteoarthritis and Cartilage in 2014, medical experts evaluated evidence on the use of drug and non-drug treatments for osteoarthritis to provide guidelines for the management of knee osteoarthritis.

In the report, capsaicin was deemed appropriate for people with osteoarthritis of the knee only (rather than multi-joint osteoarthritis) who do not have other relevant health conditions.

3) Low Back Pain

For a report published in Spine in 2016, researchers sized up previously published trials evaluating the effectiveness of herbal therapies (including capsaicin cream or plaster) in people with low back pain, and found that capsaicin reduces pain more than a placebo. The authors noted, however, that additional trials are needed to compare the therapies to standard treatments.

4) Other Conditions

Topical capsaicin is also being explored for itching, cannabis hyperemesis syndrome (a condition that can result from prolonged cannabis use), pelvic pain, and as a second-line treatment for vulvodynia.

Possible Side Effects

Studies have reported local adverse skin reactions (such as a burning sensation, pain, itching, and skin redness) in the early period of treatment that typically subside after one to two weeks of treatment.

The high-concentration patch may cause pain, inflammation, coughing, swelling, redness, and skin blisters, with pain increasing in the first two days (often requiring pain medication) and then slowly decreasing.

Transient high blood pressure has been noted, particularly with high concentration capsaicin. The risk is considered greater in people with pre-existing cardiovascular disease.

If you have a chronic nerve condition, consult your healthcare provider before using capsaicin cream.

People with HIV-neuropathy have reported diarrhea, weight loss, and throat infections after use of the high-concentration patch. 

The safety of long-term, repeated applications of high concentration capsaicin isn't known. If you are pregnant or breastfeeding, speak with your doctor.

With the high-concentration patch, the burning sensation and pain are sometimes described as feeling like a "bad sunburn". 


Here are some tips when using capsaicin cream:

  • When applying capsaicin cream, avoid contact with eyes and mucous membranes, and wash hands thoroughly afterward.
  • Although people sometimes use gloves when applying capsaicin cream at home, capsaicin can diffuse through latex gloves.
  • Capsaicin shouldn't be applied on open wounds or broken skin.
  • Care should be taken to avoid contact of the cream with others, particularly with children and pets.
  • If you apply capsaicin cream to your feet, they should be covered to avoid contaminating the floor (and spreading the capsaicin).
  • Cool, dry packs wrapped in cloth are said to alleviate the burning sensation that occurs after application. They are applied only for brief periods to avoid injuring the skin.

The Bottom Line

While not everyone responds to capsaicin cream, it may help some people manage pain in conjunction with standard treatment. The cream does require regular applications and has side effects. Higher-concentration patches are applied in a medical setting. While it doesn't require repeated daily applications, it can cause significant burning and pain in the initial days after it is applied.

If you're considering trying capsaicin cream or any other form of topical capsaicin, speak to your healthcare provider to see whether it's appropriate for you and to find out what to expect at the recommended dose. 

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View Article Sources
  • Derry S, Moore RA. Topical capsaicin (low concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD010111.
  • Derry S, Rice AS, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017 Jan 13;1:CD007393.
  • Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Herbal Medicine for Low Back Pain: A Cochrane Review. Spine (Phila Pa 1976). 2016 Jan;41(2):116-33.
  • McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88.