Causes and Risk Factors of Celiac Disease

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It's not entirely clear what causes celiac disease. In fact, most researchers believe multiple factors are involved, including your genes, your environment, and the foods you eat. You need some or even all of these factors to be present in order to develop celiac disease.

Bread and pasta

Common Causes

Celiac disease is an autoimmune disease in which gluten in your diet triggers your white blood cells to attack the tiny, finger-like projections called villi that line your small intestine and normally help you digest food. The lining is eroded until it's worn smooth. Without villi, you can't absorb vitamins, minerals, and other nutrients from food.

Your genes play a strong role—if you don't have one of the two specific genes that have been linked to celiac disease, your odds of developing the condition are very low (although they are not zero; medical research has found people who have celiac but not those genes). However, because 30% of the population has one of the genes, and only 3% of the population with one or both of these genes develop celiac disease, genetics isn't the only factor.

To develop celiac disease, you must be eating gluten. When you have celiac disease, gluten spurs your immune system to attack your small intestine. Gluten is common in the Western-style diet, so it would be unusual to avoid it when not following a strict gluten-free diet.

Finally, for you to develop celiac disease, certain factors in your environment must help to cause it. It's these factors that aren't clear; some people can consume gluten every day for decades without a problem and then develop severe celiac disease symptoms very suddenly, while some young children exhibit celiac symptoms as soon as gluten-containing grains are introduced into their diets.

Many women begin to experience celiac symptoms following pregnancy and birth, and other people find their symptoms begin following a seemingly unrelated illness—or even following a stressful time in their life. There is also research into whether a virus might trigger the condition.

Besides having first-degree family members with celiac disease, health-related risk factors include having:


The two main genes for celiac disease are HLA-DQ2 and HLA-DQ8. About 96% of those diagnosed with celiac disease (via biopsy) have one or both of those genes. Certain subsets of the HLA-DQ2 gene can increase or decrease your risk. It's likely, too, that there are other genes involved that haven't yet been identified.

Genes are inherited. As a result, celiac disease can run in families. If you have a first-degree relative (parent, sibling, or child) with celiac disease, you have a 5% to 22% chance of having it too.

HLA-DQ2 is common among people with European heritage (up to 40% of that population have it). HLA-DQ8 is most common in people from Central and South America, but it also appears in about 10% of the population overall.

There's some evidence that carrying two copies of one of the genes (either DQ2 or DQ8) may increase your risk. You would have two copies if you inherited one copy from each parent.

Genetic testing for the genes associated with celiac disease is done by collecting cells from your mouth with a swab or by spitting into a vial. This can be done by your healthcare provider, by specialized laboratories, or even by commercial genetic profile companies.

Gluten Exposure

Again, even if you are prone to developing celiac disease, you won't without exposure to gluten (which is, essentially, inevitable).

Gluten is found in wheat and some other grains. There is conflicting research as to whether the hybridized wheat of today has more gluten than wheat from a century ago. That aside, wheat, gluten, and other gluten-containing grains are found in many processed foods (and even products like toothpaste), which may result in people having more exposure to gluten now than decades ago.

Myth Buster

Some have theorized that the rise in celiac disease and non-celiac gluten sensitivity is tied to genetically modified wheat. However, since genetically-modified wheat isn't on the market anywhere, it can't be causing the increase.

There is ongoing research into whether feeding patterns in the first year of life make a difference in developing celiac disease. These studies have not found any effect associated with whether or not a child was breastfed and when gluten was first introduced to the diet.

There is weak evidence that having a high amount of gluten at the time of weaning might increase the risk of celiac disease in children who have a high familial risk.

A Word From Verywell

Celiac disease is caused by having specific genes, eating gluten, and possibly by some sort of trigger . However, medical science still doesn't know much about any of these potential factors, even though they seem to be the keys to why some people with certain genes develop celiac disease while others do not. In fact, researchers have only begun to explore various possibilities.

Frequently Asked Questions

  • What role do the HLA-DQ2 andHLA-DQ8 genes play in celiac disease?

    Certain variations of these genes are associated with celiac disease. They are part of what is called the human leukocyte antigen (HAL) complex—a group of genes that help the immune system tell the difference between proteins produced by the body and those made by viruses and other infectious microbes. In celiac disease, these genes are involved in an inappropriate immune response to a protein in gluten called gliadin.

  • Does stress cause celiac disease?

    There's evidence stress may play a role in autoimmune disorders including celiac disease. In one study, people with celiac disease reported experiencing a stressful life event a year before they were diagnosed. Pregnancy, for example, was a significant stressor.

  • What causes celiac disease in adults?

    The pathophysiology of celiac disease is the same in adults as in children: irreparable damage to the small intestine. However, when celiac disease develops in an adult, the symptoms are likely to be different than those of a child. For example, celiac disease causes diarrhea in only a third of people who develop the condition as an adult.

  • What triggers celiac disease?

    For someone who has a predisposition to celiac disease, eating foods that contain gluten will damage the cilia of the small intestine. Over time, this damage will bring on symptoms of celiac disease.

  • What foods cause celiac disease?

    Any food containing gluten can cause celiac disease. Bread, pasta, pizza, and other foods made with wheat or other grains are the most familiar sources of gluten, but gluten turns up in less obvious foods as well, such as malt (in beer and vinegar) and brewer's yeast. Gluten is also found in non-food products including lip balm, vitamins and other nutritional supplements, and play dough.

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10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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