Condylox (Podofilox) - Topical

What Is Condylox?

Condylox (podofilox) is a prescription topical medication used to treat external genital warts and perianal (around the anus) warts. The exact mechanism of action of Condylox is unknown, but it is a potent cytotoxic agent that inhibits cell mitosis which results in slowly killing and getting rid of visible wart tissue.

Condylox is available in a 0.5% gel form and a 0.5% liquid solution.

Drug Facts

Generic Name: Podofilox

Brand Name: Condylox

Drug Availability: Prescription

Therapeutic Classification: Keratolytic

Available Generically: Yes

Controlled Substance: N/A

Administration Route: Topical

Active Ingredient: Podofilox

Dosage Form(s): Gel, solution

What Is Condylox Used For?

Condylox 0.5% gel is used for the topical treatment of anogenital warts (external genital warts and perianal warts). Condylox 0.5% solution is indicated for external genital warts only. Neither dosage form is approved for use on mucous membrane warts.

How to Use Condylox

It is important to use this medication as directed by your healthcare provider. Only apply this medicine to the warts. Do not apply Condylox to unaffected skin and avoid contact with your eyes. If this medication does come in contact with your eyes, immediately flush your eyes with plenty of water and seek medical advice.

To apply Condylox:

  • Wash your hands with soap and water before and after using this medicine.
  • Use the applicator tip, your finger, or one of the cotton swabs if it is supplied with your medicine to apply Condylox to your warts (only a tiny amount is needed).
  • After applying a small amount of medicine to the affected area(s), allow the medicine to completely dry before letting anything touch the treated area(s). This includes other skin areas, such as the other leg.
  • Wash your hands thoroughly with soap and water after use.

Use Condylox as prescribed, usually twice a day (roughly every 12 hours) for three days. Do not use it for another four days. If the warts are not healed, your provider may tell you to repeat this cycle for another three days on, four days off. Do not have sex on the days that you use Condylox.

Storage

Store this medication in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze. This medication is highly flammable so keep it away from excessive heat and open flames.

What Are the Side Effects of Condylox?

This is not a complete list of side effects and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Common Side Effects

Common side effects of Condylox include mild redness, burning, itching, pain, and swelling of the skin.

Severe Side Effects

If you notice any of the following side effects, stop using Condylox and call a healthcare provider right away:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding
  • Swelling
  • Severe pain

Notify your provider if your warts do not clear up after applying the medication as prescribed and/or your warts do not clear up after four seven-day cycles (three days on, four days off). You may need to try an alternative treatment.

Report Side Effects

Condylox may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Condylox Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For warts on penis or vulva (genitals) or on skin between genitals and rectum:
      • Adults—Apply to the wart(s) two times a day for three days in a row using an applicator tip or finger. Skip four days by not applying any medicine for four days in a row. If the wart can still be seen, this application cycle may be repeated each week for up to four weeks, until the wart is gone. No more than 0.5 grams of gel should be used each day of treatment.
      • Children—Use and dose must be determined by the doctor.
  • For topical dosage form (solution):
    • For warts on penis or vulva (genitals) only:
      • Adults—Apply to the wart(s) two times a day (every twelve hours) for three days in a row using applicator tip. Skip four days by not applying any medicine for four days in a row. If the wart can still be seen, this application cycle may be repeated each week for up to four weeks, until the wart is gone. No more than 0.5 milliliters of solution should be used each day of treatment.
      • Children—Use and dose must be determined by the doctor.

Missed Dose

If you miss your dose of Condylox, apply a dose as soon as you remember. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose. Using this medication more often will not make it work better but it may increase side effects.

Overdose: What Happens If I Take Too Much Condylox?

Systemic absorption may occur following the topical use of Condylox but it is not common. Condylox should only be applied to the affected areas of the skin and it should not be ingested. If the medication is accidentally ingested or an overdose is suspected please seek medical attention immediately.

What Happens If I Overdose on Condylox?

If you or someone else has ingested Condylox, call a healthcare provider or the Poison Control Center (800-222-1222).
If someone collapses or isn't breathing after accidentally ingesting Condylox, call 911 immediately.

Precautions

Drug Content Provided and Reviewed by IBM Micromedex®

Podofilox may not be able to prevent previously healed warts from reappearing or stop new warts from growing.

This medicine contains alcohol and therefore may be flammable. Do not use near heat, near open flame, or while smoking.

What Are Reasons I Shouldn't Use Condylox?

Do not use Condylox if you have a hypersensitivity or intolerance to any ingredients in the formulation.

It is not known how Condylox may affect a fetus during pregnancy. Talk to your healthcare provider if you become pregnant while using this medication. It is also unknown how this medication is passed through human milk. Therefore, if you are plan to breastfeed, you should discuss with your provider whether you should discontinue Condylox.

What Other Medications Interact With Condylox?

No drug interactions have been reported with Condylox.

What Medications Are Similar?

Imiquimod, available under the brand names Aldara and Zyclara, is another treatment option for genital warts. It belongs to a class of medications called immune modulators, meaning it works by stimulating the immune system. This medication is applied topically as a 5% cream, usually on the same three days on, four days off cycle as Condylox.

Frequently Asked Questions

  • What is Condylox used for?

    Condylox is used to treat external genital warts and perianal warts. It is not approved to treat mucous membrane warts.

  • How does Condylox work?

    The exact mechanism of action is unknown. It helps to slowly kill and eliminate visible wart tissue.

  • What should I expect while taking Condylox?

    You may feel some mild to moderate discomfort while using Condylox. This medication slowly kills external anogenital warts. After treatment, the warts will change from a fleshy, skin color to a dry, crusted look before disappearing.

  • When should I stop taking Condylox?

    You should stop treatment with Condylox and call your provider if you have bleeding, swelling, excessive pain, burning, or itching.

How Can I Stay Healthy While Taking Condylox?

Anogenital warts are contagious which means you can give them to or get them from your sexual partner. Prior to having sex, make sure your sexual partner has been checked for anogenital warts. Condoms may help prevent giving anogenital warts to your sexual partner. Do not have sexual intercourse for the three days you are applying Condylox.

Medical Disclaimer

Verywell Health's drug information is meant for education purposes only and not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare professional. Consult your doctor before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

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4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. DailyMed. Label: Condylox- podofilox gel.

  2. DailyMed. Label: Podofilox solution.

  3. Prescribers' Digital Reference. podofilox - Drug Summary.

  4. Centers for Disease Control and Prevention. Sexually Transmitted Infections Treatment Guidelines, 2021. Anogenital Warts.