Cordran (Flurandrenolide) – Topical

What Is Cordran?

Cordran (flurandrenolide) is a topical medication used to treat inflammation and itching caused by various skin conditions.

Cordran belongs to a group of medications called topical corticosteroids (steroids), which are applied to the skin and work by reducing inflammation. This helps improve redness, itching, and irritation. 

It comes in several formulations, including cream, ointment, lotion, and tape. Your healthcare provider will prescribe the best type for you, depending on the location and severity of your skin condition. 

Drug Facts

Generic Name: Flurandrenolide
Brand Name: Cordran
Drug Availability: Prescription
Administration Route: Topical
Therapeutic Classification: Corticosteroid
Available Generically: Yes
Controlled Substance: N/A
Active Ingredient: Flurandrenolide
Dosage Form(s): Ointment, lotion, cream, tape

What Is Cordran Used For?

The Food and Drug Administration (FDA) approved Cordran to treat inflammation and itching caused by certain skin conditions, including eczema and psoriasis. These conditions can cause dry, itchy skin and red, scaly patches to form on some areas of the body. Your healthcare provider may also prescribe Cordran for other skin problems.

Be sure to let your healthcare provider know about all your symptoms so they can choose the best treatment for you.

How to Take Cordran

Refer to the directions on your prescription for how many times per day to use Cordran. Most Cordran products are applied two to three times daily. Cordran tape may be used once or twice a day.

Follow these instructions to ensure you apply Cordran correctly and safely. 

For all products:

  • Only apply it to clean, dry skin. Keep the medication away from your mouth, nose, and eyes. 
  • Wash your hands before and after use unless you are treating your hands. 
  • Do not apply to your face, underarms, or groin unless your healthcare provider has told you to do so.
  • Do not top Cordran with any coverings (such as bandages or wraps) unless instructed by your healthcare provider.

For the cream, ointment, or lotion:

  • Apply a thin layer to the affected area and gently rub it in. 
  • For Cordran lotion, be sure to shake the bottle well before using. 

For Cordran tape:

  • Wash the affected area gently with antibacterial soap or cleanser, removing any crust or scales. Let your skin dry well for one hour before applying the tape. 
  • Shave or trim the hair in the treatment area. This will allow the tape to stick well and also prevent any discomfort when removing it.
  • Cut a piece of tape slightly larger than the treatment area and round off the corners. Always cut the tape with scissors; never tear it. 
  • Pull the white paper backing off the tape. Be careful not to let the tape stick to itself. 
  • Keeping your skin smooth, apply the tape and press it into place. 
  • When it's time for your next dose, remove the old tape and wash your skin. Allow your skin to dry for one hour before applying the new tape. 

Storage

Store all Cordran products at room temperature (between 68 and 77 degrees F) in their original containers and tightly closed. Keep the cream, ointment, and lotion away from light. Avoid exposing the tape to moisture (do not store it in the bathroom).

Keep Cordran and all of your medicines in a safe location, out of the reach of children.

How Long Does Cordran Take to Work?

You should notice an improvement in your skin condition within the first two weeks of treatment. If your symptoms have not improved after two weeks, your healthcare provider may recommend a different treatment.

What Are the Side Effects of Cordran?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other reactions, contact your healthcare provider. You may report side effects to the FDA at fda.gov/medwatch or 800-FDA-1088.

Common Side Effects

Cordran is a safe medication, but you may experience some side effects. Let your healthcare provider know if you develop any reactions. Common side effects are listed in order of most common to least common:

  • Burning, itchy, or dry skin 
  • Small red or white bumps on the skin
  • Excess hair growth in the treated area 
  • Acne
  • Changes in skin color 
  • A rash around the mouth 

Severe Side Effects

Rarely, Cordran causes severe reactions. Let your healthcare provider know immediately if you develop any of the following symptoms. Call 911 if your symptoms feel life-threatening or you think you’re having a medical emergency. Severe side effects may include:

  • Severe skin rash 
  • Irritation at the site of application 
  • Skin sores 
  • Signs of a skin infection, including redness, swelling, or oozing pus 
  • Signs of an allergic reaction, including hives, wheezing, difficulty breathing, and swelling of the face, mouth, tongue, or throat

Long-Term Side Effects

Long-term use of Cordran can change the appearance of your skin. Most changes will go away after stopping Cordran, but it can take months for your skin to return to its normal appearance. Some changes may be permanent.

Let your healthcare provider know if you notice any of the following skin changes:

  • A rash with red or purple spots (purpura
  • Changes in skin color 
  • Acne or rosacea-like rashes (appear as blushing of flushing on the face)
  • Excess hair growth in the treated area 
  • Stretch marks (striae
  • Thinning of the skin (skin atrophy) 
  • Spider veins (telangiectasia)

Report Side Effects

Cordran may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious reaction, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Cordran Should I Take?

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The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For redness, itching, and swelling of the skin:
    • For topical dosage forms (cream, lotion, and ointment):
      • Adults—Apply to the affected area of the skin 2 or 3 times per day.
      • Children—Use and dose must be determined by your doctor.
    • For topical dosage form (tape):
      • Adults—Apply to the affected area of the skin every 12 hours.
      • Children—Use and dose must be determined by your doctor.

Modifications

Certain factors may affect how Cordran is prescribed or used, including the following.

Use in children: Infants and children are more likely to develop side effects from topical steroids, including slowed growth and delayed weight gain. If a healthcare provider has prescribed Cordran for your child, use it only for the prescribed amount of time. If applying it in the diaper area, avoid tight-fitting diapers or plastic pants, as these can increase the amount of the medication absorbed by the skin.

Breastfeeding: Short-term use of Cordran is unlikely to pose risks to the breastfed infant. However, it is recommended to wipe off the skin thoroughly before nursing if you've applied it to your breast or nipple area.

Pregnancy: It is not recommended to use potent corticosteroids, like Cordran, during pregnancy for long periods or in large amounts. However, Cordran is only meant to be used short term. If pregnant, talk to your healthcare provider about the risks vs. benefits of using this medication.

Missed Doses

If you forget to apply a dose of Cordran, use it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not apply extra Cordran.

Overdose: What Happens If I Take Too Much Cordran?

Cordran is a topical medication, which means you should only apply it to your skin. Never swallow Cordran, and keep it away from your mouth, nose, and eyes to avoid irritation. Tightly close Cordran and store it in a safe location, away from children.

What Happens If I Overdose on Cordran?

If you or someone else has swallowed Cordran, call your healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn’t breathing after using Cordran, call 911 immediately.

Precautions

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It is very important that your doctor check your or your child's progress at regular visits for any unwanted effects that may be caused by this medicine. Blood and urine tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.

Check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.

Do not use cosmetics or other skin care products on the treated areas.

What Are Reasons I Shouldn’t Take Cordran?

You should not use Cordran if you’ve had an allergic reaction to Cordran in the past or are allergic to any other ingredient in Cordran products.

Do not use the tape on areas that are leaking fluid or in places where skin rubs together, such as the armpit or groin folds.

What Other Medications Interact With Cordran?

Do not use Cordran with other topical steroids, as this can increase the risk of side effects. Examples of other topical steroids are:

  • Halobetasol: Brand name Ultravate
  • Clobetasol: Brand names Clobex, Cormax, Embeline, Impeklo, Impoyz, Oluz, and Temovate
  • Betamethasone dipropionate: Brand names Diprolene and Sernivo
  • Triamcinolone acetonide: Brand name Kenalog

Let your healthcare provider know about all the medications you take, including prescription and over-the-counter (OTC) creams or ointments. 

What Medications Are Similar?

Many topical steroids are available in several forms, including creams, ointments, lotions, solutions, gels, and sprays. Less potent products are available OTC, whereas stronger products require a prescription. Your healthcare provider will choose a topical steroid that is best for the location and severity of your skin condition. 

In addition to the cream, ointment, and lotion, Cordran is uniquely formulated as a tape, which prevents the medication from rubbing off on clothes or sheets. 

Other topical steroids include:

This is a list of topical steroids used to treat skin conditions similar to Cordran. It is not a list of drugs recommended to take together. In fact, you should not use these drugs together. Talk to your pharmacist or healthcare provider if you have any questions about your medications.

Frequently Asked Questions

  • What is Cordran used for?

    Cordran treats skin conditions involving inflammation and itching, such as eczema and psoriasis.

  • How does Cordran work?

    Cordran is a topical corticosteroid (steroid). Topical steroids work by reducing inflammation, which can help improve symptoms of redness, itching, and irritation.

  • What drugs should not be taken with Cordran?

    Other topical steroids should not be used with Cordran. Before starting Cordran, let your healthcare provider know of the other medications you take, including OTC topical products, so they can ensure your regimen is safe. 

  • How long does it take for Cordran to work?

    You should notice an improvement in your symptoms within two weeks. If your symptoms have not improved after two weeks of using Cordran, your healthcare provider may recommend a different treatment.

  • What are the most common side effects of Cordran?

    The most common side effects of Cordran are burning, itching, and dry skin.

How Can I Stay Healthy While Taking Cordran?

Topical steroids, like Cordran, are versatile drugs. They can help treat several skin conditions, including eczema and psoriasis, and relieve irritating symptoms.

While these drugs are generally safe, closely follow the instructions on using this medication. Make sure only to apply it to the affected area and do not cover it with bandages or wraps unless your healthcare provider tells you to do so.

In addition to prescribed treatments, skin care strategies can help you manage symptoms related to these conditions and prevent flare-ups. This can include using eczema-friendly cleansers, soaps, and moisturizers and avoiding irritating cosmetic products.

Only use Cordran for the length of time prescribed by your healthcare provider. The longer you use Cordran, the greater chance of developing side effects. Be sure to report any skin changes. Quickly identifying reactions can help keep you healthy.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

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Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  5. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol. 2014;71(1):116-132. doi:10.1016/j.jaad.2014.03.023

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By Christina Varvatsis, PharmD
Christina Varvatsis is a hospital pharmacist and freelance medical writer. She is passionate about helping individuals make informed healthcare choices by understanding the benefits and risks of their treatment options.