Brain & Nervous System More Neurological Diseases Print Corticobasal Degeneration Symptoms and Treatment Medically reviewed by linkedin Medically reviewed by Sarah Rahal, MD on November 30, 2019 Dr. Sarah Rahal, MD is a double board-certified adult and pediatric neurologist and headache medicine specialist. Learn about our Medical Review Board Sarah Rahal, MD on November 30, 2019 Written by facebook twitter linkedin Written by Esther Heerema, MSW Esther Heerema, MSW, shares practical tips gained from working with hundreds of people whose lives are touched by Alzheimer's disease and other kinds of dementia. Learn about our editorial policy Esther Heerema, MSW Westend61/Getty Images More in Brain & Nervous System More Neurological Diseases Autism Headaches Multiple Sclerosis Parkinson's Disease Stroke Alzheimer's Down Syndrome Epilepsy Migraines Head Trauma Neurological Symptoms & Diagnosis Treatment View All Corticobasal degeneration (CBD), also known as corticobasal ganglionic degeneration, is a rare, progressive neurological disorder. In CBD, brain cells atrophy (shrink) and die, and tau protein deposits build up in the brain and interfere with functioning. CBD is considered to be a type of frontotemporal dementia. Symptoms of CBD CBD shares several symptoms with Parkinson’s disease. Early symptoms include slow or clumsy movements, tremors or shakiness, muscle weakness, and stiffness. Often, the person with CBD initially has symptoms only on one side of the body. Later, as the disease progresses, both sides are affected. Some people with CBD experience what is commonly called an "alien limb." This term refers to an arm or leg that seems to move without any direction of the person. It may not even feel like the arm or leg is a part of the person's body. CBD also affects the ability to speak and understand what others are saying and can affect memory and the ability to do mathematical calculations. Finding the right word may become very difficult. Changes in personality may develop and can include compulsions, socially inappropriate behaviors, and repetitive actions. Who Gets CBD? Researchers have not yet determined what causes CBD, although it does not appear to be an inherited disorder. The average age of onset is around 60. There are an estimated 2,000 to 3,000 Americans with this disorder, although it's possible that there are others who have an inaccurate diagnosis since CBD is often initially misdiagnosed as Parkinson's or Alzheimer's disease. Treatment of CBD As with the other disorders in the frontotemporal dementia group, treatment of CBD is limited. Medications that may help relieve some of the symptoms for a limited time include cognitive enhancers (drugs used to attempt to improve the ability to think and remember) that are usually prescribed in Alzheimer’s disease, such as cholinesterase inhibitors. Other people show some improvement in their physical abilities with medications like Sinemet, a drug often used in Parkinson's, Baclofen (which helps reduce muscle rigidity or tightness), or Clonazepam, which may help decrease the muscle jerks. Physical, occupational, and speech therapy may also be ordered by the physician to try to improve the motor functioning and speech, as well as prevent muscle contractures. Prognosis CBD is a progressive disease that often causes immobility after about five years; within 10 years, the person may pass away from complications such as a pulmonary embolism, pneumonia, or another infection. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. National Center for Biotechnology Information. U.S. National Library of Medicine. Pub Med Health. Pick’s Disease. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Corticobasal Degeneration Information Page. Accessed December 11, 2011. http://www.ninds.nih.gov/disorders/corticobasal_degeneration/corticobasal_degeneration.htm The Association for Frontotemporal Degeneration. Corticobasal Degeneration. http://www.theaftd.org/ U.S. Department of Health & Human Services. National Institute on Aging. Frontotemporal Disorders: Information for Patients, Families, and Caregivers. June 2014. https://d2cauhfh6h4x0p.cloudfront.net/s3fs-public/ftd_2014_update-final-lowres.pdf University of California, San Francisco. Corticobasal Degeneration Signs and Symptoms. http://www.ucsfhealth.org/conditions/corticobasal_degeneration/signs_and_symptoms.html University of California, San Francisco. Forms of Frontotemporal Dementia. http://memory.ucsf.edu/ftd/overview/ftd/forms/multiple University of California San Francisco. Corticobasal Degeneration Treatment. http://www.ucsfhealth.org/conditions/corticobasal_degeneration/treatment.html. 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