The Link Between Depression and Rheumatoid Arthritis

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Rheumatoid arthritis (RA) is an autoimmune, inflammatory disease in which the body's immune system attacks the joints and some organs. These biological factors, as well as RA's effect on quality of life, can lead to depression. People with RA are twice as likely to have depression as the general population. This is due to a complex relationship between the two conditions.

In this article, learn more about the relationship between RA and depression, and why it's so important for depression to be diagnosed and treated alongside it.

Woman with hand pain sitting on a couch at home.

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Rheumatoid Arthritis and Depression

Scientists don't fully understand the relationship between rheumatoid arthritis and depression, but they do believe it is bidirectional. This means that rheumatoid arthritis can cause depression, and depression can also worsen rheumatoid arthritis.


About 17% of people with rheumatoid arthritis are diagnosed with depression, but due to limited mental health screening, that statistic is likely higher.

How Rheumatoid Arthritis Can Lead to Depression

When someone has rheumatoid arthritis, they experience pain, fatigue, joint damage and deformity, and more. They often can't do the activities they're used to doing, like writing, cooking, knitting, and dressing. This all affects quality of life and can lead to a person developing depression.

Additionally, the chronic inflammation and faulty immune response from rheumatoid arthritis may play a biological role in causing depression.

How Depression Worsens Rheumatoid Arthritis

Studies have found that people with rheumatoid arthritis who have depression have worse outcomes than those without depression. This includes:

  • Increased pain
  • Poorer quality of life
  • Reduced rates of remission (when symptoms improve)
  • Higher rates of mortality

It's believed that this is partially due to the impact depression symptoms (such as fatigue, apathy, low mood, and difficulty concentrating) can have on coping mechanisms.

People who have depression may have poorer adherence to medication or therapeutic exercise regimens, which can then lead to worse outcomes for rheumatoid arthritis.

One study found that people who had depression at the start of biologic treatments for RA had significantly worse odds of having a good response to treatment and reduced improvement in disease activity by one year.

How to Manage Depression

It's essential to manage depression along with RA in order to have the best outcomes. Some of the treatments for depression and RA overlap.

First, you should speak to your healthcare provider about your depression. They can prescribe antidepressants, if appropriate, or refer you to counseling or psychotherapy.

There are many proven ways to cope with depression, and a therapist can help guide you to the best tools for you.

Some techniques for managing depression include:

  • Meditation
  • Mindfulness
  • Improving quality sleep
  • Eating well-balanced and nutritious meals
  • Getting regular exercise
  • Social interaction or support groups
  • Avoiding alcohol, drugs, and nicotine

Interestingly, one 2021 study found that there was no association between rheumatoid arthritis disease activity and depression symptoms, whereas there was a relationship between higher levels of physical disability and depression.

The authors recommended that treatment goals should therefore focus on improving physical and mental functioning and well-being over solely managing medical disease activity.

Occupational therapists often work with people with RA to manage symptoms and adapt to activities of everyday living. Your healthcare provider can provide a referral to occupational therapy if recommended.

Help Is Available

If you or a loved one is struggling with RA and depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 800-662-4357 for information on support and treatment in your area. For more mental health resources, see this National Helpline Database.

How to Prevent Depression

Depression is not entirely preventable, but learning how to identify depression or a depressive episode early is essential to getting a diagnosis and treatment. This is not solely the responsibility of the patient, but it also lies in the hands of healthcare providers to screen people with RA for depression.

Some signs and symptoms of a depressive episode include:

  • Loss of interest in previously enjoyed activities
  • Fatigue
  • Feelings of sadness, apathy, hopelessness, or pessimism
  • Difficulty concentrating
  • Appetite changes
  • Sleep disturbances

A therapist can also work with you to identify your personal triggers and develop an action plan or routine to help prevent these symptoms from worsening.

Supporting Someone With Depression

If you have a loved one with RA and depression, learning more about their conditions and how they interplay is a great first step. Some additional things you can do to support them include:

  • Provide encouragement and patience and listen to their concerns and worries.
  • Don't take their attitude personally, recognize they have a medical condition.
  • Help them adhere to their medication regimen, for example, by setting alarms or filling pill planners.
  • Continue to invite them for low-pressure outings, even if they've said "no" before.
  • Motivate them to be compliant in their home exercise program, like exercising alongside them.
  • Ensure they have transportation to healthcare and therapy appointments.
  • Help them clean or organize their living space.


Depression in people with rheumatoid arthritis is twice as common as in the general population. This can be due to RA symptoms, like fatigue, affecting overall quality of life. Leaving this depression untreated can worsen RA treatment outcomes.

It's essential that healthcare providers identify depression and provide appropriate treatment alongside any existing treatments for RA in order to achieve the best outcomes.

A Word From Verywell

It's natural to feel low if you are experiencing pain, exhaustion, and lack of mobility. These things can easily lead to a lack of motivation to go about your day. If you have RA and are feeling this way, you may have depression. Depression occurring alongside RA needs to be addressed. Talk to a trusted healthcare provider about seeking treatment for your depression and RA.

Frequently Asked Questions

  • How does rheumatoid arthritis affect mental health?

    Rheumatoid arthritis can lead to depression and anxiety in multiple ways, including through reduced quality of life, increased physical disability, immune dysfunction, chronic inflammation, and other social and socioeconomic factors related to the disease.

  • How can you minimize your chances of becoming depressed from RA?

    Research shows that higher physical disability is correlated with depression among those with rheumatoid arthritis. Therefore, treating both physical and mental functioning and well-being is recommended.

  • What are the signs of depression?

    Signs of depression include losing interest in hobbies or activities, experiencing feelings of hopelessness, pessimism, sadness, or emptiness, and having changes in sleep, weight, and appetite.

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Nerurkar L, Siebert S, McInnes IB, Cavanagh J. Rheumatoid arthritis and depression: an inflammatory perspectiveLancet Psychiatry. 2019;6(2):164-173. doi:10.1016/S2215-0366(18)30255-4

  3. Matcham F, Rayner L, Steer S, Hotopf M. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysisRheumatology. 2013;52(12):2136-2148. doi:10.1093/rheumatology/ket169

  4. Vallerand IA, Patten SB, Barnabe C. Depression and the risk of rheumatoid arthritisCurr Opin Rheumatol. 2019;31(3):279-284. doi:10.1097/BOR.0000000000000597

  5. Matcham F, Davies R, Hotopf M, et al. The relationship between depression and biologic treatment response in rheumatoid arthritis: An analysis of the British Society for Rheumatology Biologics RegisterRheumatology. 2018;57(5):835-843. doi:10.1093/rheumatology/kex528

  6. National Institute of Mental Health. Depression.

  7. Uda M, Hashimoto M, Uozumi R, et al. Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross-sectional studyAdvances in Rheumatology. 2021;61(1):65. doi:10.1186/s42358-021-00223-2

By Sarah Bence
Sarah Bence, OTR/L, is an occupational therapist and freelance writer. She specializes in a variety of health topics including mental health, dementia, celiac disease, and endometriosis.