Skin Health Acne Desquamation Process and the Outer Layer of Skin By Angela Palmer Angela Palmer Facebook Angela Palmer is a licensed esthetician specializing in acne treatment. Learn about our editorial process Updated on August 17, 2022 Medically reviewed by Casey Gallagher, MD Medically reviewed by Casey Gallagher, MD Casey Gallagher, MD, is board-certified in dermatology and works as a practicing dermatologist and clinical professor. Learn about our Medical Expert Board Fact checked by Angela Underwood Fact checked by Angela Underwood LinkedIn Angela Underwood's extensive local, state, and federal healthcare and environmental news coverage includes 911 first-responder compensation policy to the Ciba-Geigy water contamination case in Toms River, NJ. Her additional health-related coverage includes death and dying, skin care, and autism spectrum disorder. Learn about our editorial process Print Desquamation is the natural process in which skin cells are created, sloughed away, and replaced.The desquamation process happens in the outermost layer of the skin called the epidermis. The epidermis itself has four unique layers. Each of these layers plays a role in desquamation. PeopleImages / DigitalVision / Getty Images Skin Cells are Born Sometimes called cell turnover, desquamation happens every second of the day, without you even noticing. New skin cells are created in the stratum germinativum, which is the deepest layer of the epidermis. This layer is also called the basal layer. Skin cells begin their life as a single layer of thick, column-shaped cells. These cells are responsible for creating every cell of your skin. The cells in this layer divide. Half of them stay behind in the stratum germinativum. The other cells begin their migration to the skin's surface. Keratin Is Made Their next stop is the stratum spinosum. Here, the skin cells change from their column-like shape to a shape that is more like a polygon. The stratum spinosum is also called the "spiny layer" because those polygon-shaped cells do look rather spiny if you were to see them under a microscope. It's also here in the spiny layer where the skin cells begin to make keratin, the tough, fibrous proteins that make up the main structure of the skin. (Keratin is the main constituent of your hair and nails, too.) Cells Flatten Out The skin cells continue to push upward from the stratum spinosum and arrive in the stratum granulosum.In this layer, the cells begin to flatten out. They have also lost their nucleus. This layer is also called the "granular layer." Want to guess why? Yes, because here the cells take on a grainy appearance. Cells Reach the Surface, Then Slough Off The skin cells have reached their final destination — the stratum corneum. Once the cells arrive at this uppermost layer of the skin they are essentially dead. The cells in the stratum corneum are very flat and tightly packed. These flat, dead cells continuously fall away as newer cells push their way to the surface. In this way, your skin is constantly renewing itself. Where do all of those dead skin cells go? You might be surprised to know that most of the dust in your home is actually made up of dead skin cells. The entire desquamation process, from cell birth to sloughing away, takes approximately 14 to 28 days. Role of Abnormal Desquamation in Acne It's believed that in people with acne, this desquamation process goes awry. Dead skin cells hang around longer than they should, clogging pores and contributing to breakouts.This is why exfoliating treatments help improve the skin. 6 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Has C. Peeling skin disorders: a paradigm for skin desquamation.Journal of Investigative Dermatology. 2018;138(8):1689-1691. doi: 10.1016/j.jid.2018.05.020 National Cancer Institute Seer Training Modules. Layers of the Skin. The Cleveland Clinic. Epidermis. U.S. National Library of Medicine. Nourishing Hair, Skin & Nails Supplement Study (Derm Aid). Thiboutot D, Del Rosso JQ. Acne vulgaris and the epidermal barrier: is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and/or functional integrity of the epidermal barrier? J Clin Aesthet Dermatol. 2013;6(2):18-24. PMID: 23441236 American Academy of Dermatology Association. How to safely exfoliate at home. Additional Reading Gerson, Joel; Ph.D.. Standard Textbook for Professional Estheticians. 8th edition. Albany, NY: Milady Publishing, 1999. By Angela Palmer Angela Palmer is a licensed esthetician specializing in acne treatment. 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