Heart Health Heart Failure Diagnosing Diastolic Dysfunction Symptoms and tests used to diagnose this specific heart failure By Richard N. Fogoros, MD Updated on August 09, 2022 Medically reviewed by Jeffrey S. Lander, MD Print Table of Contents View All Table of Contents Who Is at Risk for Diastolic Dysfunction? Symptoms Blood Test Imaging Tests Cardiac Stress Test Other Tests Complications Frequently Asked Questions Diastolic dysfunction is the heart's inability to relax after each beat, which can restrict blood pumping and increase pressure. This can lead to diastolic heart failure, also known as heart failure with preserved ejection fraction (HFpEF). Early diagnosis and treatment are key to improved outcomes. Unfortunately, not everyone experiences symptoms of the beginning stages of diastolic dysfunction. And those who do may have "normal" findings on diagnostic tests, further complicating matters. This article explains the tests used to arrive at a diagnosis and begin appropriate diastolic dysfunction treatment. It also explains complications that may arise, including diastolic heart failure. Who Is at Risk for Diastolic Dysfunction? Certain factors contribute to the risk of developing diastolic dysfunction. Some studies indicate that some risk factors are more significant for biological males vs. females, and vice versa. They include: Older age, notably in females after menopause High blood pressure Cholesterol and triglyceride levels Smoking, notably in females Diabetes, notably in males Obesity Liver-related conditions, such as fatty liver disease Diastolic Heart Failure Stages There are four stages of heart failure (lowest stage A through highest stage D) in the 2022 guidelines of the American College of Cardiology, the American Heart Association, and the Heart Failure Society of America. Certain people with HFpEF are considered class C. In the United States, 121.5 million people with high blood pressure and 28 million people with diabetes can be considered stage A. New Heart Failure Guidelines Emphasize Prevention Symptoms There's no home test for diastolic dysfunction. Diastolic dysfunction tends to develop gradually, and some people may begin to experience classic symptoms of heart failure as it progresses. 2:00 Symptoms and Complications of Heart Failure Symptoms of diastolic dysfunction include: Dyspnea (shortness of breath) Labored breathing during exercise that gets progressively worse Difficulty breathing while lying down Difficulty breathing while sleeping A chronic cough Excessive fatigue Unusual weight gain Edema (swelling) of the legs and ankles Fast or irregular heartbeat (arrhythmia) You can experience any combination of these symptoms with diastolic dysfunction, and some may affect you more than others. Systolic vs. Diastolic Heart Failure Diastolic heart failure, also called heart failure with preserved ejection fraction (HFpEF), occurs when the heart's chambers no longer fill with blood correctly. This is due to diastolic dysfunction that causes stiffening, rather than the weakened heart muscle that is the typical cause of systolic heart failure. Systolic vs. Diastolic Heart Failure B-Type Natriuretic Peptide (BNP) Blood Test B-type natriuretic peptide (BNP), which is measured with a blood test, can be elevated in association with diastolic dysfunction. BNP is a molecule released into the blood by heart cells in response to elevated pressure within the heart. It causes the kidneys to excrete sodium and water, which serves to lower the pressure in the blood vessels and the heart. There is a large gray zone between what is considered a normal level of BNP and what is not, and so this test cannot be a reliable indicator of heart failure on its own. Sometimes, a BNP blood test is used in conjunction with other tests to support a diagnosis of diastolic dysfunction. Understanding Common Blood Tests and What They Mean Laura Porter / Verywell Imaging Tests Imaging tests are useful in diagnosing diastolic dysfunction and for assessing the severity of the condition. Echocardiogram (Echo) This specialized non-invasive ultrasound provides views of the heart as it is moving. The echocardiogram can give an indication of how well the heart muscle and valves are functioning. It also can be used to assess diastolic relaxation and the degree of left ventricular stiffness. An echocardiogram can also sometimes reveal conditions that may be the cause of diastolic dysfunction: Ventricular hypertrophy, a thickened left ventricular muscle associated with hypertension and hypertrophic cardiomyopathy Aortic stenosis, a narrowing of the valve in the aorta (the largest blood vessel branching off the heart) Restrictive cardiomyopathy, when the walls of the lower chambers of the heart are too rigid to expand as they fill with blood Left Ventricular Ejection Fraction (LVEF) An echocardiogram also can measure left ventricular ejection fraction (LVEF). This is the percentage of blood the left ventricle of the heart is able to pump out with each beat. A normal LVEF is greater than 50%, which means the left ventricle is able to pump out more than half of the blood that's inside it. Usually, heart failure is associated with a low LVEF, which is a reflection of systolic function (the heart's ability to eject blood with a strong pumping action). But some people with diastolic heart failure have a normal systolic function and a normal left ventricular ejection fraction. What is Ejection Fraction? Electrocardiogram (ECG, EKG) An electrocardiogram (ECG) is a noninvasive test that evaluates the electrical system of the heart. During this test, electrodes (flat metal discs) are placed in certain positions on a person's chest, arms, and legs. The electrodes are attached to a machine that reads the electrical charges generated by each heartbeat. The test takes about five minutes and the information is graphed as wave patterns. Cardiac magnetic resonance imaging (MRI, CMR) Cardiac MRI uses a powerful magnetic field, radio waves, and a computer to produce detailed pictures of the structures within and around the heart. It requires that you remain completely still while lying inside an MRI scanner—a tube large enough to surround the entire body. A cardiac MRI can tell a doctor a lot about how much strain the heart is undergoing and can assess deformation, left atrial size, and trans-mitral blood flow. This test yields high contrast and high-resolution images by mapping radio wave signals absorbed and emitted by hydrogen nuclei (protons) in a powerful magnetic field. Because it's costly, it is not widely used. Nuclear imaging Imaging tests such as the positron emission test (PET) and the single-photon emission computerized tomography (SPECT) sometimes are used to identify diastolic dysfunction before symptoms begin. These tests involve the injection of radioactive dyes known as radiotracers. The heart's absorption of the tracers depends on how it's functioning. The resulting color changes indicate whether certain muscles of the heart are not able to pump as they normally would. How Heart Failure Is Diagnosed Cardiac Stress Test A cardiac stress test (also known as a cardiac exercise test) measures the heart's response to physical exertion in a controlled setting. It involves walking on a treadmill or pedaling a stationary bike for approximately 20 minutes during which your blood oxygen level, heart rhythm, pulse, and blood pressure are simultaneously monitored. There are several types of stress tests, any of which might be used to help diagnose diastolic dysfunction and heart failure: Electrocardiogram stress test: Electrode patches attached to the chest measure electrical signals triggered by the heart during exercise. Echocardiogram stress tests (or echo or cardio ultrasound): Sound waves create a moving picture of how the chambers and valves of the heart function while under stress. It can reveal areas of diminished blood flow, dead muscle tissue, and areas of the heart muscle wall that aren’t contracting well or may not be getting enough blood. Nuclear stress tests: Radioactive dye is injected into the bloodstream to highlight blood flow. Images created by the test show how much dye has reached various parts of the heart during exercise and at rest. Multiple gated acquisition (MUGA) scan: Uses radionuclide ventriculography (RVG) or radionuclide angiography (RNA) to produce a computerized image of the beating heart and the pumping function of the left and right ventricles. It is particularly useful for reading the overall pumping ability of the heart. Chemical stress tests: A medication such as regadenoson, dobutamine, or adenosine, is injected into the bloodstream to stress the heart. Causes and Risk Factors of Heart Failure Other Tests A few other tests may be used to diagnose diastolic dysfunction, focusing on the performance of the heart and lungs. Cardiac Catheterization Cardiac catheterization is an invasive procedure in which a long, thin, flexible tube is inserted into the arm or groin and guided to blood vessels in the heart. Dye is injected into blood vessels so they can be observed with an X-ray or ultrasound. Cardiac catheterization can reveal if there are problems with how the heart relaxes and if the ventricles are not relaxing and filling normally. Testing for inflammatory biomarkers called cytokines, when done in conjunction with cardiac catheterization, also may help to diagnose certain types of diastolic dysfunction and predict a progression to diastolic heart failure. For example, one study has found that high levels of interleukin-17 and interleukin-6 biomarkers correlated with poorer survival rates and life expectancy with diastolic heart failure. How Inflammatory Biomarkers Help You and Your Doctor Manage Inflammation Spirometry A spirometry test measures lung function, which is frequently impaired in association with heart failure. It involves breathing into a tube attached to a spirometer device that can measure how forcefully a person is able to push air out of their lungs. Chest X-Ray A chest X-ray can show if the heart is enlarged or if there are signs of congestion in the lungs. Treating Diastolic Dysfunction and Diastolic Heart Failure Diastolic Dysfunction Complications Complications of diastolic dysfunction include its progression into diastolic heart failure. Other complications of diastolic dysfunction include: Pulmonary hypertension, a serious and chronic lung condition Sudden cardiac death due to lethal arrhythmias Worsening renal (kidney) failure in those with chronic kidney disease What Can Be Done for Diastolic Heart Failure? Diastolic dysfunction and diastolic heart failure do not go away, and there currently is no cure. However, lifestyle changes and the treatment of diastolic dysfunction can slow its progress. This may include changes in diet, smoking habits, and medication to treat diabetes and other underlying causes. A Word From Verywell Although diastolic dysfunction is common, many people with this disease may never experience symptoms. Those who do may dismiss their symptoms as just normal aging. It's important to know what the symptoms are and take them seriously if you begin to experience them. Getting an early diagnosis may prevent you from suffering the serious consequences of heart failure. Frequently Asked Questions What is the number one cause of diastolic dysfunction? High blood pressure is a leading cause of diastolic dysfunction. Other factors that contribute to your risk include diabetes, obesity, and sleep apnea. People who experience high blood pressure during pregnancy, including preeclampsia, also are at risk for diastolic dysfunction. Learn More: What Is Preeclampsia? What is the difference between congestive heart failure and diastolic heart failure? Diastolic heart failure, also called heart failure with preserved ejection fraction (HFpEF), is a progressive condition that affects the heart's filling capacity. It accounts for half of all heart failure cases. Congestive heart failure (CHF) involves the heart's ability to pump blood, and is diagnosed and treated differently. Learn More: What Is Congestive Heart Failure? Is diastolic dysfunction heart failure serious? Yes, it's a chronic condition that requires lifelong treatment and lifestyle changes. There's a higher risk of related death, but many people manage their disease and live well with it. The prognosis is less favorable for older people, those with a previous heart attack, and people living with conditions including COPD and diabetes. Learn More: Symptoms of Chronic Obstructive Pulmonary Disease (COPD) 18 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Pfeffer MA, Shah AM, Borlaug BA. Heart failure with preserved ejection fraction in perspective. Circ Res. 2019;124:1598. doi:10.1161/CIRCRESAHA.119.313572 Rueda-Ochoa OL, Smiderle-Gelain MA, Rizopoulos D, Dhana K, van den Berge JK, Echeverria LE, et al. Risk factors for longitudinal changes in left ventricular diastolic function among women and men. Heart. 2019 Sep;105(18):1414-1422. doi:10.1136/heartjnl-2018-314487. Ismaiel A, Spinu M, Socaciu C, Budisan L, Leucuta DC, Popa SL, et al. Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis. Nutr Diabetes. 2022 Jan 18;12(1):4. doi:10.1038/s41387-022-00182-7. Writing Committee Members; ACC/AHA Joint Committee Members. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. J Card Fail. 2022 May;28(5):e1-e167. doi:10.1016/j.cardfail.2022.02.010. Fukamachi K. Heart failure with preserved ejection fraction: a review for the clinician. JOCCT. 2019;14(3). doi:10.19080/JOCCT.2019.14.555886 Harvard Health Publishing. BNP: An important cardiac test. Wan SH, Vogel MW, Chen HH. Pre-clinical diastolic dysfunction. J Am Coll Cardiol. 2014;63(5):407-16. doi:10.1016/j.jacc.2013.10.063 Korkmaz AN, Caliskan B, Erdem F. Evaluation of diastolic function in patients with normal perfusion and type 2 diabetes mellitus with gated single-photon emission computed tomography. World J Nucl Med. 2017;16(3):206-211. doi:10.4103/1450-1147.207278 American Heart Association. Radionuclide ventriculography or radionuclide angiography (MUGA scan). Xu L, Yan J, Zhang F, Zhou C, Fan T, Chen X, et al. Use of Inflammatory Biomarkers and Real-Time Cardiac Catheterisation to Evaluate the Left Ventricular Diastolic Function in Patients With Diastolic Heart Failure. Heart Lung Circ. 2021 Mar;30(3):396-403. doi:10.1016/j.hlc.2020.06.017. University of Pittsburgh Schools of the Health Sciences. Diastolic Dysfunction and Pulmonary Hypertension. Pezawas T, Burger AL, Binder T, Diedrich A. Importance of Diastolic Function for the Prediction of Arrhythmic Death: A Prospective, Observer-Blinded, Long-Term Study. Circ Arrhythm Electrophysiol. 2020 Feb;13(2):e007757. doi:10.1161/CIRCEP.119.007757. Kang E, Lee SW, Ryu H, Kang M, Kim S, Park SK, et al. Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data. J Am Heart Assoc. 2022 Jul 5;11(13):e025554. doi:10.1161/JAHA.122.025554. Rasmussen-Torvik L, Colangelo L, Lima J, et al. Prevalence and predictors of diastolic dysfunction according to different classification criteria: The coronary artery risk development in young adults study. Am J Epidemiol. 2017;185(12):1221–1227. doi:10.1093/aje/kww214 Maharaj R. Diastolic dysfunction and heart failure with a preserved ejection fraction: Relevance in critical illness and anaesthesia. J Saudi Heart Assoc. 2012;24(2):99–121. doi:10.1016/j.jsha.2012.01.004 Nadruz W, Shah AM, Solomon SD. Diastolic Dysfunction and Hypertension. Med Clin North Am. 2017 Jan;101(1):7-17. doi:10.1016/j.mcna.2016.08.013. Kim MJ, Seo J, Cho KI, Yoon SJ, Choi JH, Shin MS. Echocardiographic Assessment of Structural and Hemodynamic Changes in Hypertension-Related Pregnancy. J Cardiovasc Ultrasound. 2016 Mar;24(1):28-34. doi:10.4250/jcu.2016.24.1.28. Kobak KA, Zarzycka W, Chiao YA. Age and Sex Differences in Heart Failure With Preserved Ejection Fraction. Front Aging. 2022 Feb 15;3:811436. doi:10.3389/fragi.2022.811436 Additional Reading Andersen MJ, Borlaug BA. Heart failure with preserved ejection fraction: Current understandings and challenges. Curr Cardiol Rep 2014;16:501. doi:10.1007/s11886-014-0501-8 Matta S, Chammas E, Alraies C, Abchee A, et al. Association between sedentary lifestyle and diastolic dysfunction among outpatients with normal left ventricular systolic function presenting to a tertiary referral center in the middle east. Clin Cardiol. 2016;39(5):269-75. doi:10.1002/clc.22523 By Richard N. Fogoros, MD Richard N. Fogoros, MD, is a retired professor of medicine and board-certified in internal medicine, clinical cardiology, and clinical electrophysiology. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit