An Overview of PMS

Premenstrual syndrome (PMS) affects women of all ages

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Premenstrual syndrome (PMS), is a group of symptoms that occurs before the first day of a woman's period. Some women experience mild abdominal cramps for a few hours, while others can experience severe pain and mood swings for up to two weeks week before their period starts.

PMS is often diagnosed based on the timing of the symptoms. When the effects are especially burdensome, hormone levels or imaging tests may be needed to determine whether a woman has a health condition.

There are natural therapies and medical treatments that can help alleviate the effects of PMS, and you can talk to your doctor to determine which approach is best for you.


The premenstrual phase is usually a few days before a woman's period, but it can begin up two weeks before the start of menstruation. For symptoms to be considered part of PMS, they must occur within the two weeks before a woman's period and should not be present the rest of the month. PMS can begin at any age once a woman begins having menstrual periods.

There are a number of physical, emotional, and cognitive effects that can occur as part of PMS.

Common symptoms of PMS include:

  • Uterine cramps
  • Abdominal bloating
  • Sore, tender breasts
  • Food cravings
  • Irritability
  • Tearfulness
  • Mood swings
  • Sadness
  • Anxiety
  • Angry outbursts
  • Headaches or migraines
  • Trouble sleeping
  • Fatigue
  • Change in sexual desire
  • Weight gain
  • Muscle aches
  • Slight swelling of the arms or legs
  • Digestive symptoms such as nausea, diarrhea, or constipation
  • Exacerbation of digestive disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)

While you may experience some of these effects, it is unlikely that you will experience all of the different symptoms that can occur with PMS.

Many teenagers experience PMS, and each woman's symptoms may change as she gets older. For example, a woman who may be prone to PMS-associated angry outbursts for years might not experience them anymore but could begin having abdominal cramps and weight gain in the days before her period.


Some women experience especially distressing effects of PMS that can interfere with relationships, work, and overall well being.

Serious effects of PMS include:

  • Problems with marriage or relationship
  • Difficulty parenting
  • Decreased work or school performance
  • Loss of interest in socializing
  • Suicidal thoughts

If you experience depression with your PMS, you may have a form known as premenstrual dysphoric disorder (PMDD).


The effects of PMS are caused by hormonal changes that occur during a woman's menstrual cycle. Estrogen and progesterone are the main hormones in a woman's body. These hormones fluctuate throughout a woman's menstrual cycle. Before a woman's period, estrogen levels drop and progesterone levels rise.

There is also a pattern of cyclical physiologic shifts that occur throughout the body in the weeks and days before menstruation, including metabolic variations, alterations in neurotransmitters, and vascular changes. The neurotransmitters serotonin (associated with mood) and gamma-aminobutyric acid (GABA, associated with rest) are most closely linked with PMS.

All of these physiologic shifts, as well as the hormonal patterns, induce symptoms of PMS.

Some of the hormonal and physiologic patterns of a menstrual cycle and their effects on PMS include:

  • Hormone changes cause breast soreness and swelling
  • Hormone changes trigger uterine contracting (which causes abdominal/uterine cramping)
  • Metabolic variations affect appetite, weight, swelling, and energy levels
  • Neurotransmitter alterations affect mood, sleep, digestive symptoms, and can induce migraines
  • Vascular changes can affect migraines and may cause swelling of the arms and legs

Experts suggest that the alterations in estrogen and progesterone initiate the other physiologic effects of PMS . While most women have very similar patterns during the menstrual cycle, there are some minor variations between women—which is why not every woman experiences the same exact symptoms of PMS.


There are several screening tools used in the diagnosis of PMS. Generally, doctors use a medical history or questionnaire to diagnose this condition. There are no blood tests or other diagnostic tests that can verify a diagnosis of PMS.

Among the criteria for diagnosing PMS, your symptoms must disappear during or immediately after your period and not show up again until two weeks before your next period. And they must be unrelated to medications (including hormone replacement), alcohol, or drugs.

You can keep a calendar to help you keep track of the timing of your symptoms.

Menstrual Cycle Calendar

The easiest way to determine if you have PMS is to keep track of your symptoms for two or three months on a standard calendar. A menstrual cycle calendar will help you and your doctor know if you are having cyclical symptoms that correspond with your menstrual cycle.

Take these steps to fill out a menstrual cycle calendar:

  1. The first day you begin bleeding, write day 1 on your calendar
  2. Note any symptoms you experience on that day and rate each on a scale of one to 10
  3. Do this every day for two or three months

True symptoms of PMS do not begin until after day 13, so any symptoms you experience earlier in your cycle may have another cause. However, you should still include any symptoms you experience on days 1 to 13 on your calendar.


PMDD is a severe form of PMS that affects approximately 3 to 8 percent of women who menstruate. According to the Diagnostic and Statistical Manual of Mental Disorders , in order to be diagnosed with PMDD a woman must experience at least five of the following symptoms during the premenstrual phase of her cycle, and not at other times: 

  • Feelings of sadness or hopelessness, or suicidal thoughts
  • Severe stress, tension, or anxiety
  • Panic attacks
  • Inappropriate mood swings and bouts of crying
  • Constant irritability or anger that affects other people
  • Loss of interest in normal daily activities and relationships
  • Inability to concentrate or focus
  • Lethargy 
  • Binge eating

Differential Diagnosis

You may need a diagnostic evaluation to search for hormonal or uterine problems if you have extreme physical symptoms and/or irregular bleeding. This type of evaluation can include blood tests that examine hormone levels and imaging tests that examine the uterus or ovaries.

If your symptoms do not follow a cyclical pattern, your doctor may consider other conditions such as depression, anxiety, gastrointestinal disease, or thyroid disease.


There are ways to manage PMS. Some women benefit from using supplements or over-the-counter (OTC) therapies, while others may need prescription medications. Lifestyle approaches can be useful as well.

Whether or not you need treatment depends on the severity of your symptoms and their effect on your life. You can discuss your symptoms with your doctor, who can recommend the best treatment for you.

Treatments for PMS can include:

  • OTC pain medication: If you have cramps, headaches, or breast tenderness you may benefit from medications such as Advil (ibuprofen) or Tylenol (acetaminophen).
  • Supplements: Some women become deficient in vitamins, such as vitamin C, magnesium or vitamin B12. Changes in appetite can cause these nutritional deficiencies, and supplements may help with symptoms of PMS, as well as with symptoms of nutritional deficiency.
  • Prescription pain medication: If you have severe cramps, migraines, or depression, you may be given a prescription medication to alleviate your symptoms.
  • Hormonal therapy: For some women, hormone therapy with oral contraceptives, estrogen replacement, or progesterone cream can help reduce the effects of PMS. Keep in mind that hormones can have major effects on fertility and may be contraindicated in women who are at risk of breast, ovarian, or uterine cancer.
  • Acupuncture or acupressure: Research suggests that these alternative therapies may reduce some symptoms of PMS for some women.

Keep in mind that your PMS symptoms can change when you are using birth control, and you may need a new treatment approach when your symptoms change.

Lifestyle Adjustments

There are also non-medical approaches you can take to help reduce some of your symptoms. Women who have mild cramps may experience relieve by placing an ice pack on the abdomen for a few minutes.

Women who have mild mood swings may benefit from talking to a counselor or a trusted friend. Habits such as exercising, writing in a journal, or even just being aware that the mood swings are hormonal can help prevent outbursts that can damage relationships.

A Word From Verywell

PMS is very common. While most women can function perfectly fine at all times of the month, the condition can be distressing for some women. If PMS is interfering with your life, it is important that you talk to your doctor to try to seek relief of your physical and emotional symptoms so that you can function at your best.

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Article Sources

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  1. Kwan I, Onwude JL. Premenstrual syndromeBMJ Clin Evid. 2015;2015:0806. Published 2015 Aug 25.

  2. Yonkers KA, O'Brien PM, Eriksson E. Premenstrual syndromeLancet. 2008;371(9619):1200–1210. doi:10.1016/S0140-6736(08)60527-9

  3. Reed BG, Carr BR. The Normal Menstrual Cycle and the Control of Ovulation. 2018 Aug 5. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-. Available from:

  4. [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Period pain: Overview. 2008 Feb 22 [Updated 2019 Aug 1].Available from:

  5. Faratian B, Gaspar A, O'brien PM, Johnson IR, Filshie GM, Prescott P. Premenstrual syndrome: weight, abdominal swelling, and perceived body image. Am J Obstet Gynecol. 1984;150(2):200-4.

  6. Kataria K, Dhar A, Srivastava A, Kumar S, Goyal A. A systematic review of current understanding and management of mastalgiaIndian J Surg. 2014;76(3):217–222. doi:10.1007/s12262-013-0813-8

  7. Yen JY, Liu TL, Chen IJ, Chen SY, Ko CH. Premenstrual appetite and emotional responses to foods among women with premenstrual dysphoric disorder. Appetite. 2018;125:18-23.

  8. Bowen R, Bowen A, Baetz M, Wagner J, Pierson R. Mood instability in women with premenstrual syndrome. J Obstet Gynaecol Can. 2011;33(9):927-34.

  9. Nillni YI, Toufexis DJ, Rohan KJ. Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interactionClin Psychol Rev. 2011;31(7):1183–1191. doi:10.1016/j.cpr.2011.07.006

  10. Martin VT, Wernke S, Mandell K, et al. Symptoms of premenstrual syndrome and their association with migraine headache. Headache. 2006;46(1):125-37.

  11. Jehan S, Auguste E, Hussain M, et al. Sleep and Premenstrual SyndromeJ Sleep Med Disord. 2016;3(5):1061.

  12. Guillermo CJ, Manlove HA, Gray PB, Zava DT, Marrs CR. Female social and sexual interest across the menstrual cycle: the roles of pain, sleep and hormonesBMC Womens Health. 2010;10:19. Published 2010 May 27. doi:10.1186/1472-6874-10-19

  13. Ko KM, Han K, Chung YJ, Yoon KH, Park YG, Lee SH. Association between Body Weight Changes and Menstrual Irregularity: The Korea National Health and Nutrition Examination Survey 2010 to 2012Endocrinol Metab (Seoul). 2017;32(2):248–256. doi:10.3803/EnM.2017.32.2.248

  14. Tacani PM, Ribeiro Dde O, Barros Guimarães BE, Machado AF, Tacani RE. Characterization of symptoms and edema distribution in premenstrual syndromeInt J Womens Health. 2015;7:297–303. Published 2015 Mar 11. doi:10.2147/IJWH.S74251

  15. Bernstein MT, Graff LA, Avery L, Palatnick C, Parnerowski K, Targownik LE. Gastrointestinal symptoms before and during menses in healthy womenBMC Womens Health. 2014;14:14. Published 2014 Jan 22. doi:10.1186/1472-6874-14-14

  16. Lim SM, Nam CM, Kim YN, et al. The effect of the menstrual cycle on inflammatory bowel disease: a prospective studyGut Liver. 2013;7(1):51–57. doi:10.5009/gnl.2013.7.1.51

  17. Firoozi R, Kafi M, Salehi I, Shirmohammadi M. The Relationship between Severity of Premenstrual Syndrome and Psychiatric SymptomsIran J Psychiatry. 2012;7(1):36–40.

  18. Hantsoo L, Epperson CN. Premenstrual Dysphoric Disorder: Epidemiology and TreatmentCurr Psychiatry Rep. 2015;17(11):87. doi:10.1007/s11920-015-0628-3

  19. Bäckström T, Andreen L, Birzniece V, et al. The role of hormones and hormonal treatments in premenstrual syndrome. CNS Drugs. 2003;17(5):325-42.

  20. Rapkin AJ, Akopians AL. Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause Int. 2012;18(2):52-9.

  21. Draper CF, Duisters K, Weger B, Chakrabarti A, Harms AC, Brennan L et al. Menstrual cycle rhythmicity: metabolic patterns in healthy women. Sci Rep. 2018 Oct 1;8(1):14568. doi: 10.1038/s41598-018-32647-0.

  22. Henz A, Ferreira CF, Oderich CL, Gallon CW, Castro JRS, Conzatti M, et al. Premenstrual Syndrome Diagnosis: A Comparative Study between the Daily Record of Severity of Problems (DRSP) and the Premenstrual Symptoms Screening Tool (PSST).Rev Bras Ginecol Obstet. 2018 Jan;40(1):20-25. doi: 10.1055/s-0037-1608672. Epub 2017 Nov 13.

  23. Wideman L, Montgomery MM, Levine BJ, Beynnon BD, Shultz SJ. Accuracy of calendar-based methods for assigning menstrual cycle phase in womenSports Health. 2013;5(2):143–149. doi:10.1177/1941738112469930

  24. Reid RL, Soares CN.Premenstrual Dysphoric Disorder: Contemporary Diagnosis and Management.J Obstet Gynaecol Can. 2018 Feb;40(2):215-223. doi: 10.1016/j.jogc.2017.05.018. Epub 2017 Nov 11.

  25. DSM-5 Update, Supplement tp Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, September 2016

  26. Johnson SR. Premenstrual syndrome, premenstrual dysphoric disorder, and beyond: a clinical primer for practitioners. Obstet Gynecol. 2004;104(4):845-59.

  27. [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Premenstrual syndrome: Treatment for PMS. 2013 Jun 5 [Updated 2017 Jun 14]. Available from:

  28. Matyas RA, Mumford SL, Schliep KC, et al. Effects of over-the-counter analgesic use on reproductive hormones and ovulation in healthy, premenopausal womenHum Reprod. 2015;30(7):1714–1723. doi:10.1093/humrep/dev099

  29. Kaewrudee S, Kietpeerakool C, Pattanittum P, Lumbiganon P. Vitamin or mineral supplements for premenstrual syndromeCochrane Database Syst Rev. 2018;2018(1):CD012933. Published 2018 Jan 18. doi:10.1002/14651858.CD012933

  30. Usman SB, Indusekhar R, O'brien S. Hormonal management of premenstrual syndrome. Best Pract Res Clin Obstet Gynaecol. 2008;22(2):251-60.

  31. Armour M, Ee CC, Hao J, Wilson TM, Yao SS, Smith CA.Acupuncture and acupressure for premenstrual syndrome. Cochrane Database Syst Rev. 2018 Aug 14;8:CD005290. doi: 10.1002/14651858.CD005290.pub2.

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