Doxylamine in Unisom and Nyquil Not Recommended for Insomnia Treatment

Doxylamine is a sleep aid found in over-the-counter products such as Unisom and Nyquil. It's sometimes taken to treat insomnia.

Like the related medication diphenhydramine, doxylamine does not require a prescription. That doesn't mean it doesn't come with potential side effects, though. Before taking doxylamine, you should learn how well it works and what problems it can cause.

Uses

Doxylamine is an antihistamine, meaning that it treats allergies. It's also used for nighttime cold symptoms. Causing drowsiness is considered a side effect, but it can be a useful one for some people who need help getting to sleep or staying asleep. It shouldn't be used for more than two weeks to treat insomnia.

Like many sleeping pills, doxylamine affects neurotransmitters—specialized chemical messengers that send signals between brain and nerve cells (neurons). More specifically, it blocks receptors that allow the neurotransmitter histamine to affect a neuron. This causes you to get sleepy.

Before Taking

As an over-the-counter medication, the risks are thought to be slightly lower than with prescription medications that require more careful monitoring. No routine tests are recommended with its use.

Ultimately, doxylamine is not the best option if you are considering taking sleeping pills; there are a number of other choices that are better suited to aiding sleep. Doxylamine doesn't promote sleep in the same way as prescription hypnotic medications, such as benzodiazepine and non-benzodiazepine medications.

Doxylamine is non-habit forming medication. However, you can develop tolerance to it and take more than needed.

Precautions and Contraindications

Doxylamine is contraindicated for various groups.

Age Restrictions

Children under 12 years of age should not use doxylamine 25 milligrams (mg). Children under 6 and elderly patients shouldn't use it without a healthcare provider's advice.

Breastfeeding

According to a National Institutes of Health publication, small, occasional doses shouldn't cause problems with breastfed babies. However, larger doses or long-term use may cause drowsiness, irritability, and colicky symptoms in babies. It may also lower your milk supply.

Medical Conditions

People with many conditions should be cautious about doxylamine as it may cause problems or drug interactions. These conditions include:

• Glaucoma
• Hyperthyroidism
• Heart disease
• High blood pressure (hypertension)
• Asthma
• Chronic obstructive pulmonary disease (COPD)
• Pneumonia
• Peptic ulcer disease
• Prostate enlargement
• Liver disease
• Bowel or bladder obstruction

Negative drug interactions are also a risk, especially with other medications that affect the brain, so be sure to review your medications with your healthcare provider or pharmacist before starting to use doxylamine.

Side Effects

The list of potential side effects for any drug can be quite long, and doxylamine is no exception. Although you likely wouldn't experience most side effects, and may not have any at all, some that occur commonly with doxylamine include:

• Dizziness
• Loss of coordination
• Headache
• Stomach pain
• Dry mouth or nose
• Constipation
• Difficulty urinating
• Blurred or double vision

Potential Serious Reactions

While they're rare, serious side effects can result from the use of doxylamine, including:

• Severe allergic reaction, including difficulty breathing (anaphylaxis)
• Low blood cell counts (agranulocytosis, anemia, thrombocytopenia, and leukopenia)
• Abnormal heart rhythms or altered heart rate
• Seizures
• Toxic psychosis
• Inner ear problems (acute labyrinthitis)
• Hallucinations
• Confusion or delirium
• Low blood pressure

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A Word From Verywell

If you experience any difficulties when taking this drug, you should be in close contact with your primary health provider. If you wish to pursue preferred treatments for insomnia, you should likewise make an appointment and discuss the better prescription options that are available.

Effective treatment may include medications, learning better sleep habits, or cognitive behavioral therapy for insomnia (CBTI).