An Overview of the DTaP Vaccine

Childhood vaccines help to protect babies and children from serious and potentially fatal diseases. One of the recommended childhood immunizations is the DTaP vaccine. 

The DTaP vaccine is a combination vaccine that protects children ages 6 and under against 3 different infections: diphtheria, tetanus, and pertussis (whooping cough).

All three infections can cause serious complications. The Tdap vaccine, given to adolescents and adults, protects against the same diseases.

Here’s what to know before your child gets the DTaP vaccine.

A baby looks up at her dad as a healthcare provider vaccinates the baby in the arm.

Science Photo Library - IAN HOOTON / Getty Images

What Is the DTaP Vaccine?

The DTaP vaccine is a combination vaccine that protects children ages 6 and under against diphtheria, tetanus, and pertussis. It’s delivered via intramuscular injection.

An earlier version of the vaccine, known as the DTP vaccine, was developed in the 1940s. It was one of the first combination vaccines in medical history.

While the combination vaccine was effective, some parents and patients rejected it due to its side effects. 

Scientists responded by creating a safer version of the vaccine. Unlike the whole-cell DTP vaccine, the DTaP vaccine uses an acellular version of the pertussis toxin – that is, only one part of the bacterium instead of the whole cell.

Today, the DTP vaccine is no longer used in the United States. 

The DTaP vaccine has far fewer side effects and effectively protects children from three dangerous infectious diseases.

Why the DTaP Vaccine Is Important

Getting the DTaP vaccine is an important part of your child’s health. If left untreated, all three of the infections it protects against can lead to serious illness and even death.


Tetanus is an infection caused by Clostridium tetani, a type of bacteria that usually enters the body through open cuts or wounds. The toxins produced by the bacteria cause highly painful muscle contractions.

Tetanus is sometimes called “lockjaw” because it can “lock” a person’s jaw and mouth, making it difficult to swallow and breathe.


Diphtheria is caused by a toxin-producing bacteria known as Corynebacterium diphtheria. Symptoms appear two to five days after exposure and may include:

If bacteria get into the bloodstream, it can lead to heart, kidney, and nerve damage, as well as paralysis, heart failure, and death.

Pertussis (Whooping Cough)

Pertussis, also known as whooping cough, is a contagious respiratory disease caused by the bacterium Bordetella pertussis.

Symptoms include uncontrollable coughing fits, leading to a “whooping” sound when someone tries to breathe. Serious cases can lead to pneumonia.

While pertussis can affect anyone at any age, it is potentially fatal for babies under 1 year old.

DTaP vs. Tdap

The Tdap vaccine, like the DTaP vaccine, protects against diphtheria, pertussis, and tetanus. However, it's given to children 7 years and older, adolescents, and adults.

The Tdap vaccine is recommended by the Centers for Disease Control and Prevention (CDC) for:

  • Adolescents, usually at age 11 or 12, as a booster shot
  • Children ages 7 or older who haven't completed the DTaP series
  • Healthcare professionals with direct patient contact
  • Adults who have never received Tdap
  • Adults, every 10 years, as a booster shot (or every five years after a serious wound or burn)
  • Any adult in close contact with a baby
  • Pregnant women during every pregnancy, preferably early in the third trimester

DTaP During Pregnancy

Because pertussis is so dangerous for young babies, the CDC recommends that women get one dose of the Tdap vaccine during pregnancy. Protective antibodies are passed down to the baby, which can protect them from whooping cough early in life. 

It’s best to get the Tdap vaccine during the third trimester, ideally between 27 and 36 weeks.

This can reduce the risk of whooping cough to a young baby by up to 78%.

Side Effects

Side effects of the DTaP vaccine are usually mild. They can include:

  • Redness, swelling, or tenderness at the injection site
  • Fussiness
  • Fatigue
  • Decreased appetite
  • Nausea and vomiting
  • Fever

In rare cases, the entire vaccinated arm or leg may swell temporarily. 

More serious side effects that can happen after any vaccine include:

  • Very rarely, a serious allergic reaction
  • Fainting or dizziness
  • Severe pain in the injection site


The cost of a DTaP vaccine will vary based on your healthcare provider. Most insurance plans are required to provide vaccines at no cost to you.

In the United States, children under 19 can get all recommended vaccinations for free through the federal Vaccines for Children program. Your child qualifies for this program if they're:

  • Uninsured
  • Underinsured
  • Medicaid-eligible
  • Native American or Alaska Native

State health departments and federally funded health centers may also provide the DTaP vaccine at low or no cost.

Vaccination Schedule

According to the American Academy of Pediatrics (AAP), your child should get five doses (including three doses for babies and two booster shots for children) of the DTaP vaccine, usually at the following ages:

  • 2 months
  • 4 months
  • 6 months
  • 15-18 months
  • 4-6 years

DTaP Schedule

It’s recommended that most children get five doses of the DTaP vaccine between the ages of 2 months and 6 years.

Who Gets It

The DTaP vaccine is safe for the majority of babies and children. However, the vaccine might not be safe for your child if they:

  • Are severely allergic to an ingredient in the DTaP vaccine
  • Had a severe allergic reaction after a previous dose
  • Are moderately or severely ill

Allergic Reactions and DTaP

If your child had a severe or life-threatening reaction to a previous dose of the DTaP vaccine, they shouldn't get another dose.

If your child was diagnosed with a brain or nervous system disease less than a week after a previous DTaP dose, your healthcare provider might recommend a DT vaccine instead.

The DT vaccine protects against diphtheria and tetanus but not whooping cough.

Talk With Your Healthcare Provider

Before getting the DTaP vaccine, you should talk to your healthcare provider if your child:

  • Had a high fever, a seizure, or uncontrolled crying after a previous dose of DTaP
  • Ever had Guillain-Barré Syndrome
  • Had severe swelling or pain after a dose of a vaccine containing tetanus or diphtheria
  • Isn't feeling well
  • Is allergic to any component of the vaccine or has ever had an allergic reaction to a DTaP dose


The DTaP vaccine protects children ages 6 and under from three common, potentially dangerous childhood infections: diphtheria, tetanus, and pertussis (whooping cough). Children should get five doses of the DTaP vaccine, usually at 2 months, 4 months, 6 months, 15-18 months, and 4-6 years. Side effects from the DTaP vaccine are usually mild.

The TDap vaccine protects against the same infections and is given to children ages 7 and older, as well as adults. Pregnant women should get one dose of the TDap vaccine during pregnancy.

A Word From Verywell

The DTaP vaccine is an important way to protect your child from three potentially serious or even fatal infectious diseases. Talk to your healthcare provider about your child’s immunization schedule. If your child has already missed a dose, they can still get up to date to protect them against diphtheria, tetanus, and whooping cough.

Frequently Asked Questions

  • What’s the difference between the DTaP vaccine and the Tdap vaccine?

    Both the DTaP vaccine and the Tdap vaccine protect against diphtheria, pertussis (whooping cough), and tetanus. The DTaP vaccine is given in five doses to children ages 6 and under. The Tdap vaccine is given to adolescents, adults, and children ages 7 and older.

  • What’s in the DTaP vaccine?

    There are seven pediatric DTaP vaccines that are approved for use in the United States. Each one contains inactivated versions of diphtheria and tetanus toxins, as well as acellular pertussis antigens. They also use chemical compounds, such as aluminum phosphate, as adjuvants (ingredients that help to boost the vaccine’s effectiveness).

  • How long does the DTaP vaccine last?

    The DTaP and Tdap vaccines offer protection against diphtheria, pertussis, and tetanus for about 10 years. Adolescents should get a booster shot of Tdap at 11 or 12 years old. Adults should get a booster shot about every 10 years throughout their lifetime.

  • Where do you get the DTaP vaccine?

    Your child’s pediatrician will likely provide the DTaP vaccine. You can also get the DTaP vaccine at federally funded health centers, as well as many community centers, local clinics, schools, and religious centers. Ask your state health department for a list of convenient locations.

12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. Diphtheria, tetanus, and pertussis vaccines.

  2. National Institute of Allergy and Infectious Diseases. Pertussis vaccines.

  3. Klein N. Licensed pertussis vaccines in the United States. Hum Vaccine Immunother. 2014;10(9):2684-2690. doi:10.4161/hv.29576

  4. Centers for Disease Control and Prevention. Tetanus.

  5. Centers for Disease Control and Prevention. Diphtheria.

  6. Centers for Disease Control and Prevention. Pertussis (whooping cough).

  7. Centers for Disease Control and Prevention. Get the whooping cough vaccine during each pregnancy.

  8. Skoff TH, Blain AE, Watt J, et al. Impact of the US maternal tetanus, diphtheria, and acellular pertussis vaccination program on preventing pertussis in infants <2 months of age: a case-control evaluation. Clin Infect Dis. 2017;65(12):1977–1983. doi:10.1093/cid/cix724

  9. Centers for Disease Control and Prevention. Diphtheria, tetanus, and whooping cough vaccination: what everyone should know.

  10. U.S. Department of Health and Human Services. Immunization: how to pay.

  11. Healthy Children. DTaP vaccine: what you need to know.

  12. Centers for Disease Control and Prevention. About diphtheria, tetanus, and pertussis vaccination.

By Laura Dorwart
Laura Dorwart is a health journalist with particular interests in mental health, pregnancy-related conditions, and disability rights. She has published work in VICE, SELF, The New York Times, The Guardian, The Week, HuffPost, BuzzFeed Reader, Catapult, Pacific Standard,, Insider,, TalkPoverty, and many other outlets.