Durlaza (Aspirin) - Oral

What Is Durlaza?

Durlaza, commonly known by its generic name aspirin, is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to prevent blood clots, heart attacks, strokes, or death after a heart attack, or severe chest pain (angina).

The active ingredient in Durlaza is a 24-hour extended-release aspirin. This is a long-acting form of aspirin that does not work right away. It is an off-white opaque capsule containing 162.5 mg of aspirin. Durlaza works by preventing platelets from clustering in the blood. Platelets form blood clots by clumping together.

Use other forms of aspirin such as an immediate-release aspirin when a rapid effect is needed, such as for pain relief or after a heart attack.

Drug Facts

Generic Name: Aspirin

Brand Name(s): Durlaza

Administration Route(s): Oral

Drug Availability: Prescription

Therapeutic Classification: Platelet aggregation inhibitor, analgesic

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Aspirin

Dosage Form(s): Extended-release capsule

What Is Durlaza Used For?

The Food and Drug Administration (FDA) approved Durlaza for use in adults to lower the risk of a repeat heart attack, repeat stroke, or death after a heart attack, stroke, or severe chest pain (angina).

Durlaza (aspirin) drug information

Verywell / Zoe Hansen

How to Take Durlaza

Use this medicine exactly as directed by your healthcare provider. Follow all directions on your prescription label. Ask your pharmacist for any clarification you may need.

Take Durlaza with a full glass of water (eight ounces) at the same time each day. Swallow the capsule whole. Do not crush, chew, break apart, or open. Do not take two hours before or one hour after drinking alcohol.


Store Durlaza at room temperature in a tightly closed container. Keep out of the reach of children and pets. Keep away from moisture, direct light, and extreme hot or cold temperatures. When traveling, transport aspirin in your carry-on or your checked baggage in its original labeled container.

How Long Does Durlaza Take to Work?

Durlaza enters the blood, through the stomach, in two to four hours. Consuming food or alcohol can slow the rate of absorption.

What Are the Side Effects of Durlaza?

This is not a complete list of side effects, and others may occur. A medical professional can advise you on side effects. If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Like other medications, Durlaza can cause side effects. Tell your healthcare provider about any side effects you have while taking this medication.

Potential side effects of Durlaza are:

Common Side Effects

More common side effects of Durlaza can include:

Severe Side Effects

Call your healthcare provider right away if you have serious side effects. Call 911 immediately if you think you or someone else is having a medical emergency.

Serious side effects can include:

  • Allergic reaction or anaphylaxis
  • Severe bleeding
  • Bronchospasm (narrowing of airways)
  • Stomach perforation or ulcer
  • Kidney failure
  • Reye’s syndrome

Durlaza can also cause clotting disorders or abnormal blood values, including conditions such as:

  • Disseminated intravascular coagulation (abnormal blood clotting) 
  • Pancytopenia (too few red blood cells, white blood cells, and platelets)
  • Thrombocytopenia (low platelets)
  • Agranulocytosis (low white blood cells)
  • Hypoprothrombinemia (insufficiency of prothrombin, a blood-clotting substance)

Long-Term Side Effects

Aspirin use can prolong labor in people who are giving birth or cause extreme blood loss during delivery up to 36 hours after the last dose of the drug. Avoid using this medication one week before and during labor.

Report Side Effects

Durlaza may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Durlaza Should I Take?

Drug Content Provided by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release capsules):
    • To lower risk of heart attack and stroke:
      • Adults—162.5 milligrams (mg) (one capsule) once a day.
      • Children—Use and dose must be determined by your doctor.


Avoid Durlaza in the third trimester of pregnancy because it can harm the unborn baby.

It can cause low birth weight, brain bleeds, stillbirth, or early closure of the ductus arteriosus. The ductus arteriosus is a hole in the aorta that is meant to close after the baby is born. Aspirin can also prolong childbirth or cause excessive blood loss during delivery. Talk to your healthcare provider if you are pregnant or plan to become pregnant.

Durlaza can also cross into breast milk and harm the breastfed child. It is not safe for use in children. You and your provider will decide to either stop Durlaza or stop breastfeeding.

Patients with liver or kidney damage may need to avoid taking Durlaza.

Missed Dose

If you forget to take a dose of Durlaza, do not panic. You can skip the missed dose and resume your regular schedule. Do not try to double-up to make up for the missed one.

Overdose: What Happens If I Take Too Much Durlaza?

An aspirin overdose can occur if you take too much at once or if the medication builds up in the body over time.

Overdose symptoms can include: 

  • Ringing in the ears
  • Hot flashes
  • Dehydration
  • Confusion
  • Fast breathing
  • Seizures
  • Nausea or vomiting
  • Stomach pain
  • Bloody or dark stools
  • Bloody sputum
  • Vomit that looks like coffee grounds
  • Fever lasting longer than three days

What Happens If I Overdose on Durlaza?

If you think you or someone else may have overdosed on Durlaza, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Durlaza, call 911 immediately.


Drug Content Provided by IBM Micromedex®

It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine can not be used for treatment of a heart attack. Use an immediate-release aspirin in such an event.

Make sure your doctor knows if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you to.

This medicine may increase risk for bleeding problems, including stomach ulcers or bleeding. This usually occurs if you are taking aspirin with certain medicines (eg, NSAIDs, blood thinner). Check with your doctor right away if you have black, tarry stools, severe or continuing stomach pain, unusual bleeding, bruising, or weakness, or vomiting of blood or material that looks like coffee grounds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Reasons I Shouldn’t Take Durlaza?

You should avoid taking Durlaza if you have:

  • An allergy to the medication or have ever had an asthma attack after taking an NSAID
  • Asthma
  • Stuffy nose
  • Nasal polyps
  • Peptic ulcer disease: Durlaza can increase bleeding risk or cause stomach ulcers.
  • Liver or kidney damage
  • A blood clotting disorder

Do not take Durlaza during pregnancy and while breastfeeding. Durlaza can cause complications during labor and harm the baby.

Durlaza can also cause Reye’s syndrome in children. Reye’s syndrome is a deadly condition linked to aspirin use after chickenpox or other viral illnesses.

What Other Medications Interact With Durlaza?

There are some medications and other substances that interact with Durlaza. Talk to your doctor or pharmacist about any concerns you may have.

Durlaza may interact with:


Do not take Durlaza two hours before or one hour after drinking. Alcohol can affect the controlled release properties of Durlaza. If you drink three or more alcoholic drinks daily, you have a higher risk of bleeding with Durlaza.

Renin-Angiotensin System Inhibitors

You may take renin-angiotensin system inhibitors if you need help lowering your blood pressure. Using these types of medications with Durlaza raises the risk of kidney damage, low blood pressure, and high potassium levels.

Anticoagulants and Antiplatelets

Anticoagulants and antiplatelet medications are commonly known as blood thinners. They help keep blood clots from forming. You may bruise or bleed more easily when taking these with Durlaza. When you bleed, it may take longer to stop. Call your healthcare provider if you have bloody urine or if your stool is red or dark.


Anticonvulsants are medications used to treat seizure disorders. Some anticonvulsants are narrow therapeutic index drugs. This means small changes in dose or blood concentration may cause them not to work at all or have deadly side effects. Durlaza can interact with anticonvulsants to cause seizures or toxicity.


Methotrexate is a disease-modifying anti-rheumatic drug used to treat rheumatic disorders such as rheumatoid arthritis, lupus, and psoriatic arthritis. Aspirin can block the removal of methotrexate from the body, leading to toxicity. Older adults (aged 65 years and older) and those with kidney damage are most at risk.


Using Durlaza with other NSAIDs increases the risk of bleeding and kidney injury. Specifically, ibuprofen can interfere with how Durlaza works. Wait two hours after Durlaza before taking ibuprofen. Wait eight hours after ibuprofen before taking Durlaza.


Dichlorphenamide is a medication used to treat inherited muscle disorders. Taking it at the same time as Durlaza may increase dichlorphenamide or aspirin levels which can be toxic to the body.

Live Vaccines

You should not use aspirin within four weeks of receiving the influenza vaccine and six weeks of the varicella vaccine because of the risk of Reye’s syndrome.

What Medications Are Similar?

There are other medications similar to Durlaza that are also used to reduce stroke or heart attack risks.

Medications that are similar to Durlaza include:

Brilinta (Ticagrelor)

Brilinta is also an antiplatelet medicine like Durlaza. Brilinta is usually given together with lower-dose aspirin. It may be a better option for people with kidney problems, as the dose does not need to be adjusted in this group.

Plavix (Clopidogrel)

Clopidogrel is also used to lower the risk of stroke, blood clots, or heart attacks. However, it may not work well if you have genetic factors that affect the breakdown of this drug in your body.

Your healthcare provider may perform a blood test to make sure clopidogrel will work for you. Plavix tablets can be crushed, so they may be a good option for people who have trouble swallowing. It is also a safer choice in pregnancy compared with Durlaza.

Zontivity (Vorapaxar)

You must use Zontivity with either aspirin or clopidogrel. It may not be a good option for those who may be overwhelmed by handling multiple pills.

This is a list of drugs also prescribed to reduce the risk of strokes and heart attacks. It is NOT a list of drugs recommended to take with Durlaza. In fact, you should not take these drugs together. Ask your pharmacist or a healthcare provider before using other medicines for stroke or heart attack prevention. They may contain ingredients similar to aspirin.

Frequently Asked Questions

  • How long does it take for Durlaza to work?

    The body fully absorbs Durlaza in about four to 12 hours after you take it. Food can slow down this absorption.

  • How does Durlaza differ from immediate-release aspirin?

    While the body is making platelets 24 hours a day, traditional immediate-release aspirin only stays in the blood for four to six hours. Durlaza uses extended-release, microcapsule technology to expose platelets to aspirin for 24 hours. Durlaza is also only available via prescription, while immediate-release aspirin can be bought over the counter.

  • How long does aspirin last in the body?

    Aspirin leaves the body within 24 to 72 hours through the urine. It can prolong bleeding for up to 36 hours after the last dose of the drug. Caution should be taken before surgery or labor.

How Can I Stay Healthy While Taking Durlaza?

Having a stroke or heart attack can be a scary experience. Sadly, about one in four strokes are in people who have had one before. One in five people who have had a heart attack will be back to the hospital for a second one within five years. Taking medications like Durlaza can help prevent repeat strokes or heart attacks.

Durlaza is taken once daily. If you keep forgetting to take it, consider setting alarms on your phone or calendar. Ask your doctor or pharmacist any questions you might have about the medication.

Medical Disclaimer

Verywell Health's drug information is meant for education purposes only and not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare professional. Consult your doctor before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. Durlaza [package insert]. Updated September 2015.

  2. American Heart Association. Patent Ductus Arteriosus (PDA).

  3. Virani SS, Alonso A, Benjamin EJ, et al. (2020). Heart disease and stroke statistics—2020 update: a report from the American Heart Association. Circulation. 141(9):e139–e596. https://doi.org/10.1161/CIR.0000000000000757

  4. American Heart Association. Proactive steps can reduce chances of second heart attack. Updated April 4, 2019.