An Overview of Dyshidrotic Dermatitis

Hand closeup with eczema

 Daniel Bruno / Getty Images

In This Article
Table of Contents

Dyshidrotic dermatitis is a skin condition characterized by small, itchy blisters over the palms, fingers, or feet. These progress to scaly spots over the course of several weeks. Also known as dyshidrotic eczema, foot-and-hand eczema, and pompholyx, it can be associated with atopic dermatitis and seasonal allergies. While it can be treated, dyshidrotic dermatitis will most likely recur and can't be cured.

The word dyshidrotic stems from a now-outdated belief that this condition is caused by sweat gland malfunction. Pompholyx comes from the Greek word for bubble, which accurately describes the rash people experience.

Symptoms

The majority of dyshidrotic dermatitis cases involve the palms and sides of the fingers. The soles of the feet and between the toes can also be involved.

Symptoms of the condition include:

  • Deep-seated vesicles (small, fluid-filled bumps)
  • Red, inflamed skin
  • Intense itching
  • Dry, scaly, cracked patches
  • Peeling skin
  • Pain and burning

The rash can begin quite suddenly as a crop of clear, tapioca-like vesicles that appear in clusters. The vesicles resolve in three to four weeks and are replaced by 1- to 3-millimeter rings of scale. These patches may crack and peel before the skin ultimately heals.

The vesicles can sometimes blend into each other, becoming rather large blisters. Open blisters are at risk of becoming infected. If you notice increased redness, heat, pain, swelling, oozing, or crusting, call your doctor.

Burning and itching may precede a breakout. This condition can also be painful, to the point of making walking or using your hands difficult.

Chronic dyshidrotic eczema leaves the skin reddened, thickened, and with deep cracks, especially if it has been repeatedly scratched. It may also cause changes in the nail.

Causes

Nobody knows for sure what causes dyshidrotic dermatitis. While not due to a dysfunction of the sweat glands, as once thought, it does occur around those glands.

Dyshidrotic eczema is most common between the ages of 20 and 40, although it may appear at any age. Women are twice as likely to develop the condition than men.

There is a strong link between this condition and atopic dermatitis. Almost 50% of those with dyshidrotic dermatitis also have atopic dermatitis.

This leads some to believe that dyshidrotic dermatitis is a form of atopic dermatitis on the hands and feet.

It's also more common in those with seasonal allergies and those with a history of contact dermatitis. You are also more likely to develop it if you have relatives who also have dyshidrotic eczema.

Those who are on intravenous immunoglobulin therapy have a higher risk of developing the condition.

Dyshidrotic eczema is not contagious.

Trigger Factors

There are many factors that can contribute to a flareup of dyshidrotic dermatitis or make an existing rash worse:

  • Contact with metal, especially nickel: Common exposures include zippers, jewelry, coins, and belt buckles. Metal allergy may be a very important trigger factor, with some studies showing avoidance of metal completely clearing up this condition.
  • Ingestion of allergens, such as chromate, neomycin, quinoline, and others, may trigger some cases. Diets that restrict nickel-containing foods (e.g., chocolate, nuts) or cobalt sources (e.g., fish, leafy greens), for example, may be suggested in cases that aren't getting better with other treatment may be suggested. The drawback is they are very hard to stick to long term.
  • Prolonged damp hands or feet: People with professions that require hands to be in contact with water many times per day (for example, hair stylists and those in the medical field) may develop dyshidrotic eczema on their hands. Spending long periods of time in damp socks can trigger a flare on the feet.
  • Hyperhidrosis, or excessive sweating, may trigger a flare-up. Not only does it keep the skin damp for long periods of time, sweat itself is also high in nickel, which may irritate the skin.
  • Weather: Temperature extremes or drastic changes in humidity may trigger a flare. For some people, dyshidrotic eczema is worse during the change of seasons.
  • Emotional stress can make dyshidrotic dermatitis worse, though it does not cause it.

Diagnosis

There is no specific test that can definitively diagnose dyshidrotic eczema. Instead, it's generally diagnosed by a physical exam coupled with a detailed medical history.

Your physician will ask about any allergies, as well as your profession and hobbies (to see if your activities expose you to anything that could be contributing to your symptoms).

If there is any uncertainty, your physician may also order:

  • A skin scraping or biopsy to check for infection
  • Patch testing to check for allergens
  • Blood testing to test for, among other things, allergies and autoimmune disorders

Dyshidrotic eczema is often misdiagnosed and can easily be confused with other skin problems like:

Treatment

There is no cure for the condition, but it can be managed. Most dyshidrotic eczema attacks spontaneously resolve within one to three weeks.

But since the rash can be intensely uncomfortable, medications may be used to control itching and speed healing. In some cases, medications are used to help keep dyshidrotic eczema flares at bay.

Most people need a combination of treatments to see really good improvement of the rash.

Topical steroids are used as first-line treatments to help control itching and reduce inflammation. Because the skin of the hands and feet is thick and absorbs medication slowly, high-strength steroids are prescribed. Oral steroids may be used for short courses in severe cases and during acute flares.

Topical calcineurin inhibitors have been shown to be effective in some cases. These are non-steroid medications that help stimulate the release of anti-inflammatory compounds in the skin.

Immunosuppressants (such as methotrexate) are sometimes prescribed in severe cases that aren't responding to other treatments. They're most often used along with other therapies.

Over-the-counter oral antihistamines don't improve the rash itself, but may help relieve itching. Ask your doctor if these may be of help in your situation.

Wet dressings can be used to soothe and relieve itching. A cloth dampened with water or Burrow's solution (aluminum subacetate) is applied to the affected areas several times per day. Follow your doctor's instructions and guidance for wet wrap therapy.

Oral antibiotics are sometimes prescribed if the rash has become infected. Treating infection may help clear up the rash.

Botox injections don't treat dyshidrotic eczema rash, per se, but they can be used to treat hyperhidrosis of the hands or feet. Stopping excessive sweating can help reduce flareups if sweat and damp skin is a personal trigger factor.

Large blisters can be drained by a healthcare provider to help reduce pain.

Prevention

Although it's not possible to completely prevent flare-ups, you can greatly reduce their frequency with careful treatment.

Knowing your personal triggers is the best defense for preventing future outbreaks of dyshidrotic dermatitis. Try reducing your exposure to metal allergens in particular to see if that causes an improvement of symptoms.

Commit to these personal care suggestions as well:

  • Keep the skin well-moisturized: This helps keep the skin's barrier healthy and less likely to become irritated. Apply after every shower, handwashing, and throughout the day as needed. Hypo-allergenic, fragrance-free products are preferred.
  • Use gentle hand cleansers to avoid stripping and drying the skin.
  • Protect your hands and feet: Use waterproof gloves when cleaning or washing dishes, and soft cotton gloves if working in the yard. Moisture-wicking socks can help keep your feet cool and dry.

A Word From Verywell

The intense itch and pain of dyshidrotic eczema can make it a maddening condition to deal with. Remember, prevention is the best defense. Try your best to identify and avoid your personal triggers. Your physician can help you determine what those triggers may be, as well as devise an appropriate treatment plan for you.

Was this page helpful?

Article Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Lee WJ, Lee DW, Kim CH, et al. Pompholyx with bile-coloured vesicles in a patient with jaundice: are sweat ducts involved in the development of pompholyx? J Eur Acad Dermatol Venereol. 2010 Feb;24(2):235-6. doi:10.1111/j.1468-3083.2009.03383.x


Additional Reading