Endometriosis Leg Pain: Before, During, and After Periods

Endometriosis (endo) occurs when endometrial-type tissue is present outside the uterus or womb. This tissue (lesion or implant) grows and bleeds with hormone changes, just like the lining of the uterus during a menstrual cycle or period.

The tissues and nerves around the implant can get entrapped, inflamed, or irritated. When it affects nerves in the pelvis (between the hips), it can cause radiating leg pain, muscle spasms, and possibly neuropathy (numbness, tingling, weakness).

This article reviews endometriosis leg pain, the link between inflammation, nerves, and endometriosis, and options for pain relief. 

Cropped image of a woman holding her thigh in pain.

Peter Dazeley / Getty Images

Endometriosis Prevalence

Worldwide, approximately 176 million, or 10%, of those assigned female at birth have endometriosis. 

What Is Endometriosis Leg Pain?

When endometrial implants irritate, inflame, or place pressure on the nerves in the pelvis, leg pain can occur.


Leg pain associated with endometriosis differs from the soreness you may feel after a hard workout. It feels more like a stabbing, sharp, or throbbing pain. 

Nociceptive vs. Neuropathic Pain.

Nociceptive pain responds to stimuli such as injuries, burns, bruises, muscle strain, or bone fractures. Neuropathy is the damage, impairment, or dysfunction of nerves. Neuropathic pain develops from this damage, irritation, or inflammation of the nerves. This pain is sharp, stinging, shooting, or burning. It can also cause numbness or tingling, muscle spasms, and weakness.

Associated Symptoms 

In addition to leg pain, symptoms may include: 

  • Trouble walking
  • Loss of muscle mass in the buttocks or legs
  • Restless legs syndrome (RLS)
  • Problems sleeping
  • Difficulty sitting for long periods

Endometriosis can also cause:

  • Heavy menstrual bleeding or cramping 
  • Pain with sex
  • Painful urination
  • Painful bowel movements
  • Infertility (not able to get pregnant)
  • Stomach upset


Leg pain can start in your back or pelvis and radiate down both legs. You may feel pain, tingling (pins and needles), or numbness in your buttocks, thighs, calves, feet, or toes. The location depends on the nerves affected. 

During Your Monthly Cycle

Some people note that endometriosis leg pain starts a few days before they start menstrual bleeding (period), gets worse during their period, and stops once the bleeding is over.

Changing estrogen levels are responsible for this cycle. They stimulate your period and cause the endometrial implants to bleed (just like the lining of the uterus). This results in inflammation, irritation, scar tissue, and pain. 

Before and After Surgery

Leg pain can also occur if you've had surgery to treat endometriosis. There is a wide range of pain relief patterns after surgery; the pain may go away right after surgery or take a few days or weeks.

Your healthcare provider may prescribe hormone treatment before or after surgery. The goal of hormonal therapy is to keep new implants from growing.

The Link Between Inflammation, Nerves, and Endometriosis 

Endometriosis can irritate the nerves through inflammation, nerve entrapment, or pressure from the implants. The following are nerves that endometriosis can affect: 

  • Sciatic nerve: Sciatic pain (sciatica) may start in your lower back and radiate to your buttocks and down one or both legs. 
  • Obturator nerve: This nerve works with the muscle of the thigh. Irritation may cause pain in the groin, inner, or front thigh. It may also cause thigh weakness, making it difficult to walk. 
  • Femoral nerve: The femoral nerve is the major nerve in your thigh that starts near the groin. Inflammation and irritation can cause discomfort on the front and side of the thigh.
  • Pudendal nerve: This major nerve runs through the buttocks and perineum, sending information to the genital area. It can cause vaginal, urethra, and rectal pain. 

The following are also links between endometriosis and pain:

  • Nerve irritation from endometrial implants sends signals of pain to the brain.
  • There are multiple nerves in the pelvis that can be affected.
  • Endometriosis increases nerve growth where they don’t usually grow.
  • Endometrial tissue increases cytokines, which cause inflammation, and prostaglandins, which cause cramping (when there are too many).

Relief Options

For mild symptoms, you can try the following options at home:

  • Heat: Apply heat using a patch, heating pad, warm bath, or hot water bottle.
  • Cold: Use an ice pack or cool cloth (apply to the painful or inflamed area for 15 minutes several times per day).
  • Topical medications: Pain relieving patches, gels, or creams can be placed directly on the skin.
  • Movement or position change: Try changing positions or doing some light exercise and stretching to see if it takes the pressure off the nerve.

Topical Medications

Topical medications come in patches, creams, or gels. They can be placed or rubbed over sore or inflamed areas. Sometimes putting these medications on the lower back can help decrease inflammation in nerves such as the sciatic nerve. 

These medications decrease swelling. If they include lidocaine, they also numb the area.  Examples include:

  • Aspercreme (trolamine salicylate)
  • Bengay (menthol, camphor, or methyl salicylate)
  • Icy Hot (methyl salicylate-menthol)
  • Voltaren (diclofenac)
  • Salonpas (camphor, methyl salicylate, and menthol and tocopherol acetate, or vitamin E)

If approved by your healthcare provider, you can also try the following over-the-counter (OTC) pain relievers:

If the pain is moderate, severe, or progressing, your healthcare provider may suggest the following:

  • Prescription anti-inflammatory or pain medications
  • Hormonal therapy
  • Nerve blocks
  • Muscle relaxers
  • Vaginal Valium (diazepam)
  • Injections, such as Chirocaine (levobupivacaine) or Botox, BTXA, Dysport (onabotulinum toxin A)
  • Anticonvulsants, such as Neurontin (gabapentin) or Lyrica (pregabalin)
  • Surgery

Complementary and alternative medicine (CAM) treatments that may provide relief include:

  • Acupuncture 
  • Chiropractic care
  • Supplements including vitamin B1, magnesium, omega-3 fatty acids, cinnamon twig, or licorice root
  • Isoflavones
  • Boiron, Naturopathica (arnica) cream or pellets

Immediate Relief Options

If you are looking for immediate relief, try one of the following options:

  • Topical medications 
  • Hot packs
  • Cold packs 
  • Warm bath or shower
  • OTC pain reliever
  • Hip stretches (to take the pressure off the nerves)


Movement helps reduce inflammation and relax the muscles, which helps break the pain cycle. An increased heart rate pumps or circulates more oxygen and increases energy. It also stimulates serotonin and endorphins, mood-elevating chemicals and natural pain relievers.

Walking and swimming are good options as they have greater effects on serotonin, toning muscles throughout the body, and improving circulation. Stretching exercises, yoga, and Pilates are also helpful in strengthening and relaxing muscles. 

Physical Therapy

Endometriosis treatment often requires a multidisciplinary approach, which involves physical therapy specialists. Physical therapy may include: 

  • Stretching techniques
  • Breathing exercises
  • Pelvic floor therapy
  • Deep tissue massage
  • Trigger point injections
  • Tissue mobilization
  • Biofeedback 
  • Nerve stimulation

Pelvic Floor Therapy

Pelvic floor physical therapy helps improve the strength and function of the muscles in the pelvic area. This allows the muscles to relax, which can ease symptoms. 

Anti-Inflammatory Diet

Certain foods can trigger inflammation in the body. An anti-inflammatory diet is a well-balanced diet that helps you avoid those foods. It is a good option for those with endometriosis as it can help reduce chronic inflammation. 

This diet includes lots of:

  • Vegetables
  • Fruits and berries
  • Healthy fats (fish, almonds, olive oil, avocado)
  • Green tea

It discourages foods that cause inflammation, including:

  • Red meat
  • Saturated fats
  • Refined sugar
  • Caffeine
  • Large amounts of alcohol

Dark chocolate is OK if it has at least 70% cocoa. It’s also important to drink plenty of water as hydration reduces inflammation.

Excision Surgery

Excision surgery removes implants or scarring, which can help alleviate pain and improve fertility. The goal is to completely remove all of the endometriosis. However, this becomes more difficult for those with stage 4 endometriosis.

If you think you need this surgery, look for a gynecologist specializing in minimally invasive surgery techniques and endometriosis. They may also put together a team of specialists because the tissue may be outside the typical gynecological area and involve delicate areas and nerves. 

In- and Out-of-Network Specialist

The average time to receive an endometriosis diagnosis is seven to 10 years. This and the complexity of endometriosis make it important to seek a specialist. 

To help reduce costs, use in-network providers if you can. Co-pays may be reasonable if they are out of network, but it helps to check with your insurance and compare rates in advance. 

Supplemental health insurance may be an option to help cover those costs. If your employer offers flexible spending or savings, take advantage of that. It enables you to pay for medical expenses while decreasing your taxable income.

If you need financial assistance, reach out to your providers. Sometimes healthcare clinics offer payment plans, transportation resources, telehealth visits (to cut down on transportation costs), or a social worker or office manager who can help you find resources. 


Endometriosis occurs when endometrial tissue is present outside the uterus or womb. The tissue grows and bleeds with hormone changes, like the lining of the uterus. This can irritate, inflame, or place pressure on the nerves in the pelvis, causing leg pain. 

Relief options vary based on the severity of endometriosis and its symptoms. For immediate relief, try a topical medication, heat or ice pack, change positions (lie on your side), take OTC pain medications, and perform light exercises, such as swimming or walking.

Treatment may require prescription medications, hormone therapy, physical therapy, or surgery for persistent symptoms or leg pain that affects your daily activity. 

Frequently Asked Questions

  • Why does endometriosis trigger the sciatic nerve?

    The sciatic nerve starts in the lower back and goes down each leg. Endometriosis can irritate it through inflammation, entrapment, or pressure. 

  • What should you do if endometriosis leg pain affects walking?

    Talk to your healthcare provider if leg pain makes walking difficult. In the meantime, try using a cane, applying heat or ice, topical medications, or over-the-counter (OTC) pain relievers. Light exercise like swimming may help stimulate endorphins and decrease pain.

  • Do other gynecological diseases cause leg pain?

    Yes, anything that inflames, entraps, presses against, or irritates the nerves, joints, or tissues in the pelvis area can cause radiating leg pain. Examples of gynecological diseases that can cause leg pain include:

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Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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Additional Reading

By Brandi Jones, MSN-ED RN-BC
Brandi is a nurse and the owner of Brandi Jones LLC. She specializes in health and wellness writing including blogs, articles, and education.