Overview of EnteraGam for IBS With Diarrhea

EnteraGam is a novel approach for the treatment of diarrhea predominant IBS (IBS-D). It is classified by the FDA as a prescription medical food in that it must be prescribed by your doctor or other licensed healthcare provider. The product is a powder that is comprised of "serum-derived bovine immunoglobulin/protein isolate" (SBI) and is sold under the name "EnteraGam." You mix the powder into a liquid and drink it.

Physician consulting with patient
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SBI was originally designed to support intestinal health in farm animals, but more recently has been evaluated for treating enteropathy (intestinal disease) in humans, including addressing the loose and frequent stools of IBS-D. The product is derived from cows and is comprised of approximately 90% protein. The product is not absorbed at the level of the stomach or small intestine so that it makes its way intact into the large intestine. The mechanism of SBI isn’t completely clear, but the ingested beef antibodies may improve proper functioning of the GI tract. IBS patients may have an inflammatory disorder, which is not yet definitively understood, and therefore why EnteraGam works is not clear.

What the Research Says

Although there is much more evidence that SBI can improve enteropathy in animals, some preliminary clinical trials have tested the product for use in humans, specifically enteropathy in children, those with HIV infection, and people who have IBS-D. A small, but randomized, double-blind, placebo study, on the use of SBI for IBS-D, showed that using the product for six weeks resulted in significant reduction in the following symptoms:

No serious side effects were seen, although a few subjects withdrew due to nausea.

These results must be taken with a bit of caution. It was a small study, and patients in the control group also experienced some symptom improvement, suggesting a possible contributory placebo effect.

A different 2013 study assessed symptom improvement in a small number of IBS-D or IBS-M patients who used the product for six weeks. This was not a double-blind, placebo study. Symptom improvement was experienced by approximately three-quarters of the study participants. No serious side effects were noted, although a few patients did stop using the product due to side effects such as constipation, diarrhea, and nausea.

Hopefully, future research will shed more light on the helpfulness of EnteraGam as an effective treatment option for IBS-D.

How It Helps

Based on research to date (animal and human) SBI is thought to possibly:

  • Offer nutritional benefits.
  • Bind with toxins in the gut.
  • Reducing inflammation-causing cytokines.
  • Support the immune system.
  • Reduce intestinal permeability (leaky gut syndrome).
  • Improve the balance of the gut flora.


EnteraGam has been characterized by the FDA as "Generally Recognized as Safe." It should not be used by people who are allergic to beef. It has not yet been evaluated for safety in pregnant or nursing women or those with a compromised immune system. It has been tested in small studies for use with infants and children with no serious side effects noted.

Is EnteraGam Right for You?

Although the research on EnteraGam is in the preliminary stages, it certainly looks promising in terms of offering a safe and potentially effective treatment option for IBS-D. If your symptoms have not been responsive to other management strategies, you may want to speak with your healthcare provider about giving it a try.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. EnteraGam. What is EnteraGam?

  2. Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein GL. Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy. Clin Exp Gastroenterol. 2014;7:181-90. doi:10.2147/CEG.S62823

  3. Weinstock, L. and Jasion, V. (2014) Serum-derived bovine immunoglobulin/protein isolate therapy for patients with refractory irritable bowel syndromeOpen Journal of Gastroenterology4, 329-334. doi:10.4236/ojgas.2014.410047.

  4. Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49-60. doi:10.4137/CGast.S13200

  5. Valentin N, Camilleri M, Carlson P, et al. Potential mechanisms of effects of serum-derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea-predominant irritable bowel syndrome. Physiol Rep. 2017;5(5). doi:10.14814/phy2.13170

Additional Reading

By Barbara Bolen, PhD
Barbara Bolen, PhD, is a licensed clinical psychologist and health coach. She has written multiple books focused on living with irritable bowel syndrome.