Taking Fentanyl After Surgery

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Fentanyl is a pain medication frequently used after surgery. Fentanyl is a synthetic opioid analgesic, a pain medication similar to morphine but approximately 100 times stronger. It is a controlled substance and requires a prescription from your healthcare provider.

Fentanyl is also commonly known as fentanyl citrate, Sublimaze, Actiq, Duragesic, Fentora, and Matrifen.

Cropped shot of patient hand receiving intravenous fluid directly into a blood vein.
Boy_Anupong / Getty Images

How Is It Given?

Fentanyl is available in a variety of forms. In the hospital, Fentanyl is most commonly given as an IV injection or an IV drip. The drug can also be given with a PCA (patient controlled analgesia) pump, where the patient presses a button to have a small dose of pain medication delivered through their IV.

For patients taking fentanyl at home, a transdermal patch can be worn, which delivers the medication through the skin. For patients with cancer, Actiq is available to provide medication orally in a “lollipop” form. A buccal pill, a medication that dissolves in the mouth between the cheek and gum, and a nasal spray are also available.

The administration of fentanyl is selected based on the patient's needs and concerns about safety. For example, if a patient is worried that a child in the house might mistake the Actiq medication for candy, another delivery method would be selected.


Fentanyl dosages vary widely based upon the reason for the pain, the duration of usage, and the tolerance the patient may have to pain medications. Fentanyl is a very potent pain medication. Many patients will not qualify for the fentanyl patch or Actiq lollipops, as they only appropriate for patients with a tolerance for Fentanyl or other opioid pain medications.

Due to the potency, initial doses of fentanyl are very small. For example, an adult one-time IV dose may be 50 to 100 mcg. However, for long-term patients, such as cancer patients, doses may be substantially higher.

A dose of 100 mcg of Fentanyl is roughly equivalent to 10 mg of morphine.


Fentanyl, like many opioid medications, can cause respiratory depression. This means the drive to breathe can be seriously diminished. This effect can last longer than the pain-relief effects, making it essential to be aware of any breathing issues prior to taking an additional dose. Fentanyl should not be taken with other pain medications without your healthcare provider’s knowledge, and should never be taken with alcohol.

When used properly and over short periods, most patients do not experience addiction or symptoms of physical withdrawal when the drug is no longer in use. However, there is a significant risk of addiction when taking fentanyl for extended periods of time. Withdrawal symptoms are possible with dose reduction or conversion to a different medication, as well as if the medication is stopped abruptly. Your healthcare provider will gradually reduce your dose to prevent these symptoms.

Side Effects

  • Respiratory depression
  • Constipation
  • Dry mouth
  • Dizziness
  • Sleepiness

Special Concerns

Like any opioid medication, fentanyl has the potential to be both addicting and abused. Fentanyl is very strong when compared to other opioids such as morphine, and when street drugs are laced with fentanyl, the chances of overdose are dramatically increased. In addition, it is often blended with heroin to increase the "high" the user experiences. This blending makes it more likely that the individual will overdose, particularly if they are not aware that the fentanyl is present and take their usual dose of heroin. 

Like other opioids, Narcan can be given to block and reverse the effects of an overdose of fentanyl. Fentanyl overdoses are far rarer in patients who are using the medication as prescribed rather than obtaining it illegally, as the patient often uses fentanyl for pain after years of taking medication for chronic pain. That said, a suspected opioid overdose should be quickly treated with Narcan (naloxone hydrochloride). In March 2023, the Food and Drug Administration (FDA) approved Narcan Nasal Spray as an over-the-counter (OTC) emergency treatment for opioid overdose. 

Also of great concern is the use of black-market versions of fentanyl, particularly carfentanil, which is easily mistaken for fentanyl but is much stronger. Some use it as a substitute for heroin. Carfentanil is so strong that when Canadian authorities seized a one kilogram shipment in 2016 they estimated that there was enough of the drug to kill tens of millions of people.

Actiq: The Fentanyl “Lollipop”

Actiq, the Fentanyl dosage system that is sucked on like a lollipop, is designed for use by cancer patients with significant pain. Actiq is not appropriate for everyone: only patients who have a demonstrated tolerance for opioid medications equivalent to 60 mg of morphine per day should use this method of Fentanyl delivery.

Actiq is like a lollipop in appearance, yet it delivers a dose of medication that could be fatal to adults, and especially to children, who are not acclimated to opioid medications.

Child safety kits are available to prevent the accidental ingestion of this medication from the makers of Actiq. To obtain your Actiq child safety kit, call 1-888-534-3119 to make your request.

Duragesic Fentanyl Patch

The Duragesic fentanyl patch is designed to deliver a specific dose of fentanyl over the course of three days. When used and removed according to the instructions, the patch still frequently contains enough fentanyl to be lethal to smaller bodies.

For this reason, it is essential that patches are discarded where children and pets cannot find them. The manufacturer of the patch recommends flushing used patches down the toilet immediately after removal. If you have a well or septic system, check whether your hospital, pharmacy, or other local organization has a medicine take-back program.

Cutting or altering the patch can cause an overdose of fentanyl. Never use a patch that is not intact, or move a patch from one area of the body to another after application, as this may damage the integrity of the patch.

A Word From Verywell

Fentanyl is an extremely effective pain medication, but with strong pain medications comes risks, particularly the risk of overdose. When taken appropriately, in the smallest dose needed for the shortest amount of time necessary, fentanyl is safe. There is a real risk of addiction and serious or life-threatening effects when used for long periods of time. Also take special care to protect children and pets from discarded patches, which can be lethal to them.

6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Carlos F. Ramos-Matos; Wilfredo Lopez-Ojeda. Fentanyl. Treasure Island (FL): StatPearls Publishing; 2019.

  2. Fentanyl citrate. Drug Summary. Prescribers Digital Reference. 2019.

  3. Dormer D. Deadly opioid carfentanil bound for Calgary seized in Vancouver. Enough of the drug seized to produce 50M fatal doses. CBC News. August 09, 2016.

  4. Actiq.com. Indications and usage. Cephalon, Inc. 2017. 

  5. College of Pharmacists of British Columbia. Safe Disposal of Fentanyl Patches. 2019.

  6. FDA. FDA Drug Safety Communication: FDA requiring color changes to Duragesic (fentanyl) pain patches to aid safety―emphasizing that accidental exposure to used patches can cause death. February 21, 2018.

Additional Reading
  • Fentanyl. National Institute On Drug Abuse. 2016.

By Jennifer Whitlock, RN, MSN, FN
Jennifer Whitlock, RN, MSN, FNP-C, is a board-certified family nurse practitioner. She has experience in primary care and hospital medicine.