What Is Fibroid Degeneration?

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Uterine fibroid degeneration occurs when a fibroid outgrows its limited blood supply and begins to die.

This article discusses the symptoms, causes, diagnosis, and treatment of uterine fibroid degeneration.

Black woman lying on couch holding lower abdomen in pain

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Fibroid Degeneration Symptoms

Uterine fibroids are benign uterine growths made of smooth muscle cells and fibrous tissue, ranging in size from the size of a grain of rice to the size of a melon.

Uterine fibroids mainly develop in and around the uterus (womb), but rarely may develop in the muscular portion of the uterine wall or form stalks that form pouches or stalks outside the womb. The size and location of uterine fibroids usually determine whether or not you will develop symptoms.

You may not be aware you have fibroids—many people with a uterus have no symptoms. The main signs of fibroids include:

For some people with a uterus, a degenerating fibroid is what first draws attention to their fibroids. Common symptoms of fibroid degeneration include:

  • Acute abdominal pain lasting a few days to a few weeks
  • Swelling of the abdomen
  • Fever

Pedunculated Fibroids

Fibroids can grow on a stalk extending out from the uterine wall (pedunculated fibroids). In these cases, the stalk can become twisted, cutting off the blood supply to the fibroid. If this occurs, not only is the pain intense, but it lasts longer than a normal degeneration. In severe cases, surgery may be required to remove the fibroid.


The exact cause of fibroids is unknown but there are several risk factors that can play a role in your chances of developing fibroids. These can include:

  • A family history of fibroids
  • Not having children
  • Early-onset of menstruation (getting your period at a young age)
  • Late age for menopause

Fibroids need two elements to survive, hormones and a blood supply. If a fibroid grows so quickly that it outstrips its blood supply you may experience a sharp, stabbing pain in the abdomen and swelling. Increases in estrogen during pregnancy can increase the chances of fibroid growth and subsequent degeneration.

Fibroid Degeneration in Pregnancy

Fibroid enlargement may be influenced by increased estrogen levels during pregnancy. Fibroids do not usually grow during pregnancy, but some research points to the first trimester as the most likely time that they may.

The larger the fibroid the more likely it is that fibroid degeneration will may occur. Large fibroids outgrow their blood supply. Even more, the growing uterus may distort and kink blood vessels, compromising the fibroid's blood supply.

One type of fibroid degeneration -- called red degeneration due to it's red color appearance on examination -- occurs in 8% of fibroid growths. While is makes up only 3% of all uterine fibroids it may be a troublesome cause of pregnancy complications, such as severe pain, in many women.

Is Fibroid Degeneration a Good Thing?

Though fibroid degeneration does decrease the size of fibroids, this is only temporary—a degenerated fibroid is likely to expand and degenerate again. Though many people with fibroids don’t experience symptoms on a daily basis, when fibroid degeneration starts, it can be uncomfortable and disruptive.


The first signs of fibroids may be detected during a routine pelvic exam. A number of tests may show more information about fibroids:

  • Ultrasound uses sound waves to create a picture of the uterus and other pelvic organs.
  • Magnetic resonance imaging (MRI): This test creates detailed images of your internal organs by using magnets and radio waves.
  • Hysteroscopy uses a slender device (the hysteroscope) to see the inside of the uterus. It is inserted through the vagina and cervix (opening of the uterus). This lets your healthcare professional see fibroids inside the uterine cavity.
  • Laparoscopy uses a slender device (the laparoscope) to help your healthcare professional see the inside of the abdomen. It is inserted through a small cut just below or through the navel. Fibroids on the outside of the uterus can be seen with the laparoscope.

Differential Diagnosis

Fibroids degeneration is often easily confused for other medical conditions because its symptoms are nonspecific and mimic other medical common issues. Other common conditions that are confused with fibroid degeneration include:

Uterine Leiomyosarcoma

A single uterine fibroid that undergoes rapid growth may raise a concern about uterine leiomyosarcoma, which is a rare (less than one in 1,000) cancerous fibroid tumor. Symptoms of this rare tumor include:

  • Pain
  • Unintentional weight loss
  • Nausea and vomiting
  • A lump under the skin


If fibroid degeneration is causing pain and discomfort, your healthcare provider may suggest home remedies such as using a heating pad on your abdomen or massaging your lower abdomen. Pain medication may provide relief for a few days or weeks until the pain subsides. Your provider may also order imaging such as a CT of the abdomen, a urine analysis, and blood tests to rule out other causes of your pain.

There are many treatment options for fibroids so make sure you discuss all your options with your healthcare provider. The following treatments are frequently used to help manage fibroids:

Frequently Asked Questions

  • How long does the pain last from shrinking fibroid degeneration?

    Severe pain associated with fibroid degeneration can last anywhere from several days up to four weeks.

  • How long does fibroid degeneration take?

    Unfortunately, there’s no simple answer to how long fibroid degeneration can take. Degeneration is linked to the growth of fibroids, which can be tricky to predict as everyone's fibroids grow at different rates.

    We do know that fibroids can grow in the first trimester of pregnancy, and that degeneration is seen most often in pregnant people with large fibroids (greater than 5 centimeters) during the second and third trimesters of pregnancy.

  • Where does a fibroid go during degeneration?

    If a large fibroid goes through the process of degeneration, it can shrink back to a much smaller size as it loses oxygenated blood. As long as it has a supply of blood and nutrients, it will not disappear, but it may be smaller.

  • What is red degeneration of a fibroid?

    Red degeneration is a type of degeneration that occurs most commonly during pregnancy, where as many as 30% of fibroids present will increase in size. It can cause pain and bleeding, which must be investigated by your healthcare provider.

A Word From Verywell

Uterine fibroid degeneration can cause significant discomfort, but thankfully there is treatment available. The first step in treatment is to be aware of fibroid degeneration, especially if you are pregnant. Meeting frequently with your OBGYN is one way to ensure that you and your healthcare provider discuss the signs to look out for if you are worried about degeneration. Severe abdominal pain and fever can be a sign of many illnesses, but if you know you have fibroids and you start experiencing sharp lower abdominal pains, reach out to a healthcare provider so you can get the care you need.

11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By Shamard Charles, MD, MPH
Shamard Charles, MD, MPH is a public health physician and journalist. He has held positions with major news networks like NBC reporting on health policy, public health initiatives, diversity in medicine, and new developments in health care research and medical treatments.