Symptoms of Gallbladder Disease

Pain in the upper right side of the abdomen, where the gallbladder is located, is the most common symptom of gallbladder disease. Depending on the type of gallbladder disease and whether there are any complications, it can also cause fever, nausea, vomiting, and/or jaundice.

The complications of gallbladder disease are mainly due to the presence of gallstones and may include an infection of the common bile duct (called ascending cholangitis), inflammation of the pancreas (called pancreatitis), gangrene of the gallbladder (called gangrenous cholecystitis), or bowel obstruction from a gallstone (called gallstone ileus).

gallbladder disease symptoms
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Frequent Symptoms

The common symptoms of gallbladder disease may help differentiate the usual causes.

Abdominal Pain

Most gallstones stay in the gallbladder and don't cause symptoms. Some become lodged in the cystic duct (a tube located at the neck of the gallbladder) or in the common bile duct (a tube that carries bile from the gallbladder to the intestines).

  • A gallstone in the common bile duct is called choledocholithiasis and may cause intermittent or constant discomfort.
  • A gallstone obstruction of the cystic duct is called biliary colic.

Biliary colic is an intense, dull ache that usually is located in the upper right side of the abdomen. It also can occur in the upper middle part of the abdomen (called the epigastrium) or, less often, beneath the sternum. Sometimes the pain travels (radiates) to the right shoulder blade or to the back. The pain caused by biliary colic can be steady or intermittent and it can be triggered by eating a meal that's high in fat.

Besides a gallstone attack, upper right-sided abdominal pain may occur in other gallbladder diseases, such as:

  • Cholecystitis: This condition refers to gallbladder inflammation. While it most commonly occurs as a complication of gallstones (called acute cholecystitis), it may also occur without gallstones (called acalculous cholecystitis). Unlike a gallstone attack, the biliary-like pain of cholecystitis lasts longer than six hours and is usually associated with fever and an elevated white blood cell count.
  • Biliary dyskinesia: This condition causes upper abdominal pain and occurs when the sphincter of Oddi (a muscular structure located at the junction where the bile ducts drain into the small intestine) does not function properly, causing bile blockage.
  • Functional gallbladder disorder: This disorder causes episodes of upper abdominal pain without gallstones or problems with the sphincter of Oddi.
  • Advanced gallbladder cancer: Gallbladder cancer generally does not cause symptoms. As the cancer grows, though, pain in the upper right side of the abdomen may begin, along with palpable lumps on the belly, jaundice, nausea, fatigue, and weight loss.


Jaundice, signaled by yellowing of the whites of the eyes and skin, may occur with gallbladder diseases that obstruct the bile ducts.

This photo contains content that some people may find graphic or disturbing.


DermNet / CC BY-NC-ND

Nausea and Vomiting

Nausea and vomiting may occur with a gallstone attack but are more common with cholecystitis (inflammation of the gallbladder) or pancreatitis (inflammation of the pancreas).


Fever should not occur with a gallstone attack but may occur with gallbladder inflammation or with infection/inflammation of the biliary tract.

Rare Symptoms

There are also less common symptoms of gallbladder disease. Sometimes it isn't clear whether the symptoms are caused by gallstones or by another coexisting medical condition, like gastroesophageal reflux disease (GERD) or peptic ulcer disease.

Less Common Symptoms

Some of the less common symptoms include:

  • Chest pain
  • Burping
  • Feeling full sooner than usual after eating
  • Regurgitating fluids
  • Bloating
  • Burning sensation behind the breastbone or in the upper central abdomen
  • Nausea and/or vomiting without biliary colic


Pruritus (itching) is another symptom, occurring commonly with a condition called primary sclerosis cholangitis, a chronic, inflammatory disease of both the gallbladder and liver. The pruritus that occurs with these conditions is often very debilitating and likely occurs as a result of bile acid accumulation.

Primary sclerosing cholangitis can also cause upper right-sided abdominal pain, jaundice, and fatigue.

Pruritus can also occur with advanced forms of pancreatic cancer due to blockage of the bile duct.


Several complications may occur as a result of gallbladder disease.

Acute Cholangitis

Acute cholangitis is caused by a bacterial infection of the biliary tract associated with biliary obstruction. In addition to fever and upper right-sided abdominal pain, the condition can cause jaundice, low blood pressure, and confusion.


Pancreatitis refers to inflammation of the pancreas and most commonly occurs as a complication of gallstones. This is because the gallbladder and pancreas share a bile drainage duct, so an obstructing gallstone can prevent the flow of pancreatic enzymes.

Symptoms of gallstone pancreatitis include a rapid onset of severe, epigastric pain, as well as nausea and vomiting. Treatment entails hospitalization for nutrition and fluids, pain control, and monitoring for severe complications, including necrotizing pancreatitis, which can be life-threatening. Usually, procedures to remove the duct blockage, or the entire gallbladder, also are performed.

Gangrenous Cholecystitis

This is the most common complication of cholecystitis, especially for older people, people with diabetes, or anyone who delays seeking treatment for their gallbladder attacks. Gangrenous cholecystitis is considered a medical emergency, requiring surgical removal of the gallbladder (a cholecystectomy) right away.

Gallbladder Perforation

If the gallbladder becomes gangrenous, a perforation (a hole in the wall of the gallbladder) may develop, resulting in a pericholecystic abscess (a collection of pus within the gallbladder). This complication is serious and life-threatening, requiring an emergent cholecystectomy.

Cholecystoenteric Fistula/Gallstone Ileus

If a hole forms in the gallbladder, a fistula (passage) into the small intestine may develop. If a gallstone passes through the fistula, a bowel obstruction may occur (called gallstone ileus).

Emphysematous Cholecystitis

Infection of the wall of the gallbladder with gas-forming bacteria may lead to emphysematous cholecystitis. Older age and diabetes increase the risk of this complication.

When to See a Healthcare Provider

If you are experiencing any abdominal pain, it's important to see your healthcare provider for a proper diagnosis. If your healthcare provider diagnoses you with gallstones, they may refer you for a surgical evaluation, especially if you are experiencing recurrent episodes of biliary colic.

Gallbladder Disease Doctor Discussion Guide

Get our printable guide for your next doctor's appointment to help you ask the right questions.

Doctor Discussion Guide Old Man

If you are experiencing abdominal pain that is severe, persistent, and/or associated with fever, severe nausea, vomiting, and/or jaundice, be sure to seek medical attention right away at the hospital.

Frequently Asked Questions

  • What are the symptoms of gallbladder disease?

    Pain in the upper right quadrant of the abdomen (where the gallbladder is located) is the hallmark symptom of gallbladder disease, which is an umbrella term for any condition affecting the gallbladder. Depending on the specific condition, other symptoms may commonly include:

    • Fever
    • Jaundice
    • Nausea and vomiting
    • Pruritis (itching)

    Be sure to contact your healthcare provider if you have any type of severe abdominal pain, and especially if you have signs of jaundice, such as yellowing of the eyes, as serious complications may arise.

  • What does gallbladder pain feel like?

    Gallbladder pain, most typically a result of gallstones, may feel like a sharp, burning pain in the upper right portion of the abdomen, and may radiate to the back and right shoulder blade. Your abdomen may feel very tender and you may have an upset stomach. The pain from a gallstone attack can last between a few minutes to a few hours. Gallbladder pain also can occur without gallstones, such as in the case of acalculous cholecystitis.

  • How can I tell if I have gallbladder disease or another condition?

    Your healthcare provider can rule out other diagnoses based on a physical exam, medical history, blood tests, and an abdominal ultrasound, along with other imaging tests. There are several conditions that can cause symptoms that may feel similar to those of gallbladder disease, including:

  • What causes gallbladder disease?

    Gallbladder disease is most commonly caused by gallstones, which are crystals that form inside the gallbladder when too much cholesterol or bilirubin (a byproduct of red blood cell breakdown) is present. High cholesterol is a major risk factor for gallstones, and there may also be a hereditary link. Gallbladder disease may also be caused by gallbladder inflammation (cholecystitis), biliary dyskinesia, gallbladder cancer, and primary sclerosing cholangitis.

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American College of Gastroenterology. Gallstones and gallstone disease. Updated July 2013.

  2. American Cancer Society. Signs and Symptoms of Gallbladder Cancer

  3. American Liver Foundation. Primary Sclerosing Cholangitis (PSC)

  4. National Institute of Diabetes and Digestive and Kidney Diseases. Pancreatitis

  5. Ogawa A, Shikata K, Uchida HA, et al. Case of emphysematous cholecystitis in a patient with type 2 diabetes mellitus associated with schizophrenia. J Diabetes Investig. 2012;3(6):534-5.

  6. National Organization of Rare Disorders. Acute cholecystitis. Updated 2019.

  7. Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancerGut Liver. 2012;6(2):172-87. doi:10.5009/gnl.2012.6.2.172

Additional Reading
  • American Cancer Society. (2016). Signs and Symptoms of Gallbladder Cancer.
  • Dayal N, Meseeha. (2017). StatPearls. Biliary Colic.
  • Zakko SF, Afdhal NH. (2016). Acute cholecystitis: Pathogenesis, clinical features, and diagnosis. Chopra S, (ed). UpToDate, Waltham, MA: UpToDate Inc.
  • Zakko SF. (2017). Uncomplicated gallstone disease in adults. Chopra S, (ed). UpToDate, Waltham, MA: UpToDate Inc.
  • Zaliekas J, Munson JL. Complications of gallstones: the Mirizzi syndrome, gallstone ileus, gallstone pancreatitis, complications of "lost" gallstones. Surg Clin North Am. 2008 Dec;88(6):1345-68.

By Colleen Doherty, MD
 Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis.