Gluten Intolerance in Fibromyalgia & Chronic Fatigue Syndrome

Is gluten a problem for you?

Is gluten bad for people with fibromyalgia (FMS) and chronic fatigue syndrome (ME/CFS)? Would you feel better eating a gluten-free diet?

Tray of gluten-free items in a bakery display
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You can certainly find a lot of people online who say cutting out gluten has really improved their symptoms. With the media attention, gluten-free diets have received over the past several years, it stands to reason that a lot of people with these illnesses have given them a shot.

Both anecdotal results and research shows that being gluten-free doesn't help all of us—for some people, it's life-altering; for others, it does nothing other than take away their favorite foods for a while.

We still don't have a ton of research, but we have learned a little bit about FMS and gluten over the past few years. As is so often the case, we don't yet have research to guide us when it comes to ME/CFS.

The Research of Gluten & Fibromyalgia

People who can't handle gluten generally have significant intestinal problems, which can include pain, cramping, diarrhea, and just about any other digestive problem you can think of. The two main causes of gluten intolerance are celiac disease—which is an autoimmune reaction to gluten in the intestinal lining—and non-celiac gluten sensitivity

We have a study published in Arthritis Research & Therapy that suggests Celiac disease may be more common in people with FMS and irritable bowel syndrome (IBS) than in those with IBS alone. However, it was a small study, involving just 104 people, seven of whom tested positive for Celiac.

For a separate study, which came out in BMC Gastroenterology, the same research team then put those seven people on a gluten-free diet for a year to see how symptoms responded. Results suggested that cutting out gluten improved not only celiac symptoms but also FMS and IBS symptoms, as well.

But what about the 93 percent of people with FMS who don't have celiac disease? 

The same researchers looked again at women with FMS/IBS along with lymphocytic enteritis (watery diarrhea associated with inflammation of the intestine and the presence of a particular immune marker.) They found that a gluten-free diet improved symptoms of all three conditions in these people, as well.

In 2016, a study in the Journal of Clinical Gastroenterology compared the effects of a gluten-free diet to a low-calorie diet in people with both FMS and symptoms of gluten sensitivity. Both diets appeared to reduce gluten-sensitivity symptoms and there wasn't any difference in their effect on other symptoms.

In light of this, it could be that simply eating a healthy diet—and not specifically a gluten-free one—is what's generally helpful in FMS. It'll take more research to know for sure.

However, a study in Rheumatology International states that 20 women with FMS and gluten sensitivity all improved on a gluten-free diet. Researchers said:

  • for 15 of the 20 participants, chronic widespread pain disappeared (FMS in remission) and they returned to work or normal life
  • for the other five, chronic widespread pain was dramatically improved
  • those who'd been on opioid painkillers were able to go off of them
  • fatigue, digestive symptoms, migraine, and depression improved

This research team concluded that gluten sensitivity may be an underlying cause of FMS, and a treatable one.

So, while results are somewhat mixed, it looks like people with FMS+certain digestive problems may well benefit from a gluten-free diet.

For those with FMS who don't have these digestive problems, we don't have the research to say either way.

Should You Be Gluten Free? 

It's too soon to know what the relationship of gluten is to these conditions. However, if you want to see whether a gluten-free diet helps you feel better, it's safe to try as long as you approach it properly. Be sure to talk to a healthcare provider and educate yourself before you start.

Here's a list of Verywell resources on gluten to help you:

Gluten-related symptoms can be extremely similar to those of FMS and ME/CFS—including some neurological symptoms. They're also similar to IBS, which is extremely common in FMS and ME/CFS. Instead of looking for the existence of a symptom, you may need to keep a food/symptom log to see if certain symptoms get worse when you eat gluten-containing foods or improve when you avoid them.

A Word From Verywell

A gluten-free diet isn't easy. However, if it helps you feel better, it may be well worth it. Examine your symptoms and your eating habits, educate yourself, and talk to your healthcare provider.

If you try it and figure out you're not one of the people who get significant relief from eating gluten-free, don't despair. You have plenty more options to explore for alleviating your symptoms.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Rodrigo L, Blanco I, Bobes J, De serres FJ. Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study. Arthritis Res Ther. 2013;15(6):R201. doi:10.1186/ar4391

  2. Rodrigo L, Blanco I, Bobes J, De serres FJ. Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. BMC Gastroenterol. 2013;13:157. doi:10.1186/1471-230X-13-157

  3. Rodrigo L, Blanco I, Bobes J, De serres FJ. Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: a case-control study. Arthritis Res Ther. 2014;16(4):421. doi:10.1186/s13075-014-0421-4

  4. Slim M, Calandre EP, Garcia-leiva JM, et al. The Effects of a Gluten-free Diet Versus a Hypocaloric Diet Among Patients With Fibromyalgia Experiencing Gluten Sensitivity-like Symptoms: A Pilot, Open-Label Randomized Clinical Trial. J Clin Gastroenterol. 2017;51(6):500-507. doi: 10.1097/MCG.0000000000000651

  5. Isasi C, Colmenero I, Casco F, et al. Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia. Rheumatol Int. 2014;34(11):1607-12. doi:10.1007/s00296-014-2990-6

By Adrienne Dellwo
Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.