Allergies Anti-Itch Creams to Soothe Itchy Skin Topical Steroids, Antihistamines, and Anesthetics By Daniel More, MD Daniel More, MD Daniel More, MD, is a board-certified allergist and clinical immunologist. He is an assistant clinical professor at the University of California, San Francisco School of Medicine and currently practices at Central Coast Allergy and Asthma in Salinas, California. Learn about our editorial process Updated on December 17, 2021 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Jurairat J. Molina, MD Medically reviewed by Jurairat J. Molina, MD Facebook Jurairat J. Molina, MD, is a board-certified allergist who has been practicing in field of allergy and clinical immunology for the past two decades. She owns Corpus Christi Allergy Associates in Corpus Christi, Texas. Learn about our Medical Expert Board Print If you have itchy skin, also known as pruritus, there are several anti-itch lotions and creams you can try to get some relief. Some are available over the counter, while others require a prescription. Each type helps ease itching in a different way: Topical steroids reduce inflammation.Topical antihistamines block a chemical in the body that produces itching related to an allergy.Topical anesthetics numb the skin. There are many different things to consider when choosing an anti-itch cream. One big factor is why you are itching in the first place. There are several possible causes, from allergies to bug bites, burns to irritations and allergies, and even long-term or recurring skin conditions like psoriasis and eczema. This article explores different types of anti-itch creams, which conditions they work best for, and when to speak with your doctor. Verywell / Brianna Gilmartin Topical Steroids Topical steroids are the best anti-itch creams for any type of inflammation of the skin. This may be due to a variety of issues including rashes (dermatitis), eczema, and psoriasis. They are available in a variety of strengths and formulas, both with and without a prescription. You're likely already familiar with hydrocortisone cream, the over-the-counter option. Ointments and creams are the strongest topical steroids, while gels and sprays are the weakest. Topical steroids have fewer side effects than steroids taken by mouth. And lower-strength formulations pose less of a risk than more potent options. How much product you apply to your skin can also make a difference. Regardless, all steroids should be used carefully and generally under the guidance of a healthcare provider. Topical steroids are meant for short-term use and may lead to problems if overused. Potential issues include thinning of the skin, stretch marks (striae), and enlarged blood vessels. Absorbency, or how well your body takes in the medication, depends on several things like: The thickness of the skinHow much skin is being treatedThe strength of the creamHow often the cream is appliedThe type of medication (for example, ointment versus gel) Keep in mind that topical steroids can be quite expensive, as insurance does not always cover them. Generic and over-the-counter topical steroids tend to be the most wallet-friendly. 3 Ways Topical Steroids Reduce Skin Inflammation Can Children Use Topical Steroids? It's important to talk to your child's pediatrician before applying a topical steroid. Children are more sensitive to the negative effects of topical steroids, so weaker products should be used if possible. In addition, topical steroids like Cutivate (fluticasone) and Elocon (mometasone furoate) may be safer for kids since less of the steroid is absorbed. Cutivate is the only topical steroid approved by the U.S. Food and Drug Administration for children age 3 months and older. Topical Steroids for Children Topical Antihistamines Allergies occur when your body's immune system overreacts to a triggering substance, known as an allergen, and releases a chemical called histamine. Histamine leads to allergy symptoms, such as itching, that range from mild to severe. Antihistamines are medications that block the action of histamine in your body. This reduces your allergic response. Antihistamine cream can be applied to the skin to help reduce or eliminate allergy-related itchiness. For example, if you have a metal allergy, you might use a topical antihistamine if you have a reaction to wearing a watch. These types of anti-itch creams may also be helpful in treating eczema. Topical antihistamines, such as Benadryl cream or Caladryl lotion, should be applied at the lowest dose for the shortest time needed. Long-term use of topical antihistamines may lead to increased side effects when taking oral antihistamines. Other negative reactions from overuse of topical antihistamines include irritation, rash, and sunlight sensitivity. Topical Anesthetics Topical anesthetics are typically used to numb pain, but they may also be used for itchiness associated with certain skin issues such as minor burns, bug bites, and poison ivy. These drugs work by blocking nerve endings in the skin from sending signals to the brain. Keep in mind that some anesthetics, such as Lanacane cream (benzocaine), can actually cause an itchy rash known as contact dermatitis. Summary Anti-itch creams and other products that get applied to the skin can help those with itchy skin find relief. Topical steroids, topical antihistamines, and topical anesthetics are the most common anti-itch medicines available. To choose the right one, it's important that you know the main cause of your itchiness. Be sure to speak with your doctor if you have any concerns regarding your symptoms, if your itching continues without relief, or if you plan on applying the cream to a child or infant. A Word From Verywell Anti-itch creams may also be used to help soothe itching caused by infections such as yeast infections, ringworm, and scabies. But, if you have an infection, you will also need additional medication to treat it. This and the fact that some of these infections are contagious is even more reason to see a healthcare provider if you're not sure what's causing your itchiness. How to Put a Stop to Itching Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 11 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Song J, Xian D, Yang L, Xiong X, Lai R, Zhong J. Pruritus: progress toward pathogenesis and treatment. Biomed Res Int. 2018;2018:9625936. doi:10.1155/2018/9625936 Zirwas MJ, Barkovic S. Anti-pruritic efficacy of itch relief lotion and cream in patients with atopic history: comparison with hydrocortisone cream. J Drugs Dermatol. 2017;16(3):243-247. Rogers PJ, Wood SM, Garrett EL, et al. Use of nonprescription topical steroids: patients' experiences. Br J Dermatol. 2005;152(6):1193-8. Coondoo A, Phiske M, Verma S, Lahiri K. 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