Causes and Risk Factors of a Heart Attack

A heart attack (myocardial infarction, or MI) occurs when a portion of the heart muscle is deprived of blood and becomes damaged. In most cases, a heart attack is an acute event that occurs when an atherosclerotic plaque in the wall of a coronary artery becomes dislodged and blocks a smaller artery in the heart muscle. This often occurs due to longstanding coronary artery disease (CAD). There are other conditions that can lead to myocardial infarction as well. 

Senior with Chest Pain
Patrick Heagney / Getty Images

Common Causes

A heart attack is necrosis (death) of the heart muscle. This occurs due to insufficient blood supply. A thrombus (localized blood clot) due to a dislodged coronary artery plaque is the most common reason for heart muscle necrosis, and there are several other causes as well.

Acute Coronary Syndrome 

When a coronary artery plaque—a build-up of lipids and other substances in the artery—becomes dislodged, it immediately causes the formation of a blood clot (localized thrombosis) that impedes blood flow to the heart.

This event is called acute coronary syndrome, or ACS. The consequences of ACS depend on the extent to which the artery is blocked by the new blood clot. Acute coronary syndrome associated with typical CAD is, by far, the most common cause of myocardial infarction.

When a blood clot dissolves quickly, before the heart becomes damaged, the episode is referred to as unstable angina. Often, though, the blockage is severe enough to cause death of a portion of heart muscle that receives its blood supply from the damaged artery—this is a heart attack.

The Two Types of Heart Attack

Coronary Artery Spasm

Also known as Prinzmetal angina, vasospastic angina, or variant angina, coronary artery spasm is exactly what it sounds like: a sudden involuntary contraction of a coronary artery.

Most people with coronary artery spasm will have episodes of angina, most often experienced as chest pressure or pain, rather than an actual myocardial infarction. However, a severe and prolonged episode of coronary artery spasm can result in permanent damage to a portion of the heart muscle.

Microvascular Angina

Very rarely, a condition called microvascular angina (or cardiac syndrome X) will lead to a heart attack. Microvascular angina is caused by endothelial dysfunction, in which the smaller coronary arteries fail to dilate (widen) normally, creating an obstruction to blood flow.

People with microvascular angina will have normal-looking coronary arteries during cardiac catheterization, a test used to evaluate and treat heart conditions.

Stress Cardiomyopathy

Nicknamed "broken heart syndrome," stress cardiomyopathy is sudden, severe heart failure triggered by extreme emotional trauma or physical stress.

With appropriate treatment, most people who have this condition survive and have recovery of heart function. But in some cases, part of the heart muscle can be permanently damaged.

The cause of this condition is unknown, but it is thought to be related to endothelial dysfunction, similar to microvascular angina.

Viral Myocarditis

Viral myocarditis is a viral infection that directly affects the heart muscle. Viral myocarditis is not typically considered a cause of myocardial infarction, though it often does cause permanent heart muscle damage. It is believed to produce extensive localized inflammation in the cardiac muscle and interruption of the local blood supply.

Blood Clotting Disorders

Certain disorders of the blood-clotting pathway, such as Factor V Leiden deficiency, predispose to abnormal blood clotting. People with such conditions can develop acute thrombosis of a coronary artery even without underlying CAD, and thus, can experience myocardial infarctions.

Coronary Artery Embolism

A myocardial infarction can occur if a blood clot, usually originating within the heart, embolizes (breaks free) and becomes lodged in a coronary artery, interrupting the blood supply to part of the heart muscle.

Certain medical conditions increase the risk of blood clot embolization, including atrial fibrillationdilated cardiomyopathy, and the presence of an artificial heart valve. In these cases, blood thinners are often prescribed to help prevent this from happening.


Genetic factors that may be involved in a person's risk of heart attack can be directly linked to a particular cardiovascular condition or to an elevated risk of a trait associated with an increased heart disease risk, such as a tendency to be overweight, have abnormal blood lipid levels, or develop type 2 diabetes or hypertension.

While some specific genes and hereditary patterns have been identified, there are many unknowns when it comes to genetic risk factors for heart attack.

For example, it's known that, in some families, the elevated risk is clearly related to an identifiable inherited disorder such as familial hypercholesterolemia.

However, although researchers have been able to identify certain gene variants associated with diseases that ultimately lead to heart failure, such as like hypertrophic cardiomyopathy, having the gene variant does not necessarily mean that you will develop this condition.

Non-Controllable Risk Factors

Aside from genetics, there are a handful of other uncontrollable factors that can increase the possibility a person could have a heart attack:

  • Age: The risk increases for men who are 55 or older and women who are 65 and older.
  • Chronic kidney disease
  • Type 1 diabetes
  • For women, being post-menopausal or have had an ovary removal

Lifestyle Risk Factors

Whether you have a genetic predisposition to heart attacks or not, your risks can often be reduced with healthy lifestyle strategies.

Keep in mind that lifestyle factors can put anyone, regardless of family history, at an increased risk of a heart attack.

The most important ones include:

Smoking is the chief cause of heart attacks in people under 40.

Frequently Asked Questions

What are the signs of a silent heart attack?

A silent heart attack is one that doesn't cause dramatic symptoms—if any at all.

If they're present, symptoms may include:

  • Pressure, discomfort, or a feeling of fullness in the chest (rather than outright pain)
  • Discomfort in the arms (either or both), back, neck, jaw, or stomach
  • Trouble breathing
  • Dizziness or lightheadedness
  • Nausea
  • Cold sweats

Can being stressed cause a heart attack?

Psychosocial factors, including chronic stress, are linked to heart disease, which contributes/or can lead to heart attacks.

Sudden stress, such as the loss of a loved one, can cause what's called takotsubo cardiomyopathy, also known as broken heart syndrome. When it first occurs, takotsubo cardiomyopathy can feel like a heart attack.

Can an otherwise healthy person have a heart attack?

Yes. It's possible to maintain a heart-healthy lifestyle and still have a heart attack. This is most likely to happen if you have a family history of cardiac problems. If heart disease runs in your family, tell your primary care physician so they can monitor your cardiac health.

A Word From Verywell

Most heart attacks are caused by the dislodging of an atherosclerotic plaque in a coronary artery, but there are several other, much less common causes as well. More important to know: There are many things you can do to prevent this from happening, from eating a healthy diet to getting regular exercise to not smoking (or kicking the habit if you already do). These measures may help mitigate your risk even if heart problems run in your family, and they'll help prevent you from developing other chronic conditions as well.

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  1. The American Heart Association. Understand your risk for excessive blood clotting.

  2. Harvard Health Publishing. Heart attack (myocardial infarction). Updated February 2019.

  3. Baylor Scott & White Heart and Vascular Hospital. Angina pectoris, unstable.

  4. NIH: National Center for Advancing Translational Sciences. Prinzmetal's variant angina.

  5. American Heart Association. Microvascular angina. Updated July 31, 2015.

  6. Bugiardini R, Badimon L, Collins P, et al. Angina, "normal" coronary angiography, and vascular dysfunction: risk assessment strategies. PLoS Med. 2007;4(2):e12. doi:10.1371/journal.pmed.0040012

  7. Johns Hopkins Medicine. Stress cardiomyopathy symptoms and diagnosis.

  8. Kassas I, Tran K-V, Fitzgibbons T, et al. Endothelial Dysfunction and Inflammation in Stress CardiomyopathyCirculation. 2018;134(1).

  9. Harvard Health Publishing. Myocarditis. Updated December 2018.

  10. Dowaidar M, Settin A. Risk of myocardial infarction related to factor V Leiden mutation: a meta-analysis. Genet Test Mol Biomarkers. 2010;14(4):493-8. doi:10.1089/gtmb.2010.0017

  11. American Heart Association. About heart attacks. Updated July 31, 2016.

  12. Nesheiwat Z, Goyal A, Jagtap M. Atrial Fibrillation (A Fib). In: StatPearls [Internet]. Updated Feb 14, 2020.

  13. Centers for Disease Control and Prevention. Know your risk for heart disease. Updated December 9, 2019.

  14. Singh A, Gupta A, Collins BL, et al. Familial hypercholesterolemia among young adults with myocardial infarction. J Am Coll Cardiol. 2019;73(19):2439-2450. doi:10.1016/j.jacc.2019.02.059

  15. NIH US National Library of Medicine Genetics Home Reference. Familial hypertrophic cardiomyopathy. Updated March 17, 2020.

  16. American Heart Association. Understand your risks to prevent a heart attack. Updated June 30, 2016.

  17. American Heart Association. Lifestyle changes for heart attack prevention. Updated July 31, 2015.

  18. Penn Medicine. 4 Silent Heart Attack Signs. Nov 10, 2020.

  19. The American Institute of Stress. Stress can cause a cardiac event that resembles a heart attack. Apr 3, 2020.

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