How to Prevent Another Heart Attack

If you have had a heart attack (also called a myocardial infarction, or MI), you likely have coronary artery disease (CAD). (Talk to your healthcare provider to confirm that you have CAD.) While heart attacks can be caused by other conditions, CAD is overwhelmingly the most common cause.

CAD is a chronic disorder that most often affects the coronary arteries in more than one location, and that tends to progress over time. This means that you need to take steps to reduce your odds of having another MI in the future.

To prevent another heart attack, you and your healthcare provider will need to address two separate issues. First, you will need to take action to prevent re-rupture of the atherosclerotic plaque that caused your MI. Second, you will need to do everything you can to slow or halt the progression of your underlying CAD.

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Reducing the Immediate Risk

Patients who survive an MI may have an increased risk of experiencing a recurrence of acute coronary syndrome (ACS) within a month or one to two years. ACS, which is caused by the rupture of a plaque, produces either unstable angina or another MI. 

These "early" recurrences of ACS are usually caused by the re-rupture of the same plaque that caused the original MI. The risk of having an early recurrence is higher when the "culprit" plaque is still producing a significant partial blockage in the coronary artery.

If your acute MI was treated by the invasive approach (that is, with immediate angioplasty and stenting), then the culprit plaque likely will already have been dealt with.

The story is different if instead you were treated non-invasively with thrombolytic drugs. These drugs, also called “clot-busters," open the occluded artery by dissolving the acute blood clot that occurs with ACS. However, the culprit plaque remains an issue. So, before you leave the hospital it will be important to evaluate whether a significant partial blockage is still present. This evaluation can be done either with a cardiac catheterization, or a nuclear stress test.

If it is determined that a significant blockage remains, your healthcare provider will discuss options for therapy aimed at preventing an early recurrence of ACS—including medical treatment for CAD, angioplasty, and stenting, or coronary artery bypass grafting.

Reducing the Longer-Term Risk

Too often after an MI, patients are left with the impression that, yes, they had a significant medical problem, but now it has been dealt with, and they can just go on with their lives as if not much has changed.

But it can't be stressed enough that atherosclerosis is a chronic progressive disease that most often affects several locations within the coronary arteries. Any atherosclerotic plaque, regardless of its size, can rupture and produce ACS.

Once you have had an MI, you need to do everything you can to slow or halt the progression of that underlying disease process, particularly drug therapy and lifestyle changes.

Drug Therapy After a Heart Attack

To help prevent future MIs, you should be given certain drugs—statins and aspirin—that have been shown to either slow the progression of CAD or prevent the sudden occlusion of a diseased coronary artery (by preventing the acute blood clotting that causes the occlusion).


Several clinical trials now show that taking a statin drug after an MI significantly reduces the risk of having another MI, and also the risk of death. This result applies even to patients whose cholesterol levels are not especially high. So unless you simply cannot tolerate statins, you should be taking one after your heart attack.


Aspirin reduces the "stickiness" of the blood platelets, and thus reduces the chance of developing a blood clot at the site of an atherosclerotic plaque. Aspirin has been shown to significantly reduce the risk of death in patients with known CAD and should be prescribed in every MI unless there are strong reasons not to.

Your healthcare provider may also decide to give you medications aimed at preventing angina—like nitrates or calcium channel blockers—as well as beta blockers and ACE inhibitors to help prevent heart failure.

Lifestyle Issues After a Heart Attack

Just as important as drug therapy are the lifestyle changes that will reduce your long-term risk after an MI. These include achieving and maintaining an optimal weight, beginning a heart-healthy diet, ending tobacco use, achieving excellent control of diabetes and hypertension (if present), and engaging in regular exercise. 

Everyone understands that making these lifestyle changes is a lot more difficult than taking a pill. But remember: receiving a diagnosis of CAD is really a call to arms. You have a disease that will get worse over time unless you approach it like you would a cancer diagnosis. The treatment is not easy but usually quite effective. So steel yourself, get focused, and make the lifestyle changes that you need to make.

An important aspect of helping you achieve these critical lifestyle changes is for your healthcare provider to refer you to a good cardiac rehabilitation program. Too many healthcare providers, unfortunately, neglect this important step. If yours forgets, remind him or her.

You will also want to ask your healthcare provider specifically when it's safe for you to resume driving, sexual intercourse, and any other potentially strenuous or dangerous activities.

Frequently Asked Questions

  • Will a second heart attack feel like the first one?

    Not necessarily. The symptoms can be different. What's more, some people experience angina (chest pain) when they're physically active and may mistake it for a second heart attack. Talk to your healthcare provider about what to be aware of and when to call 9-1-1.

  • How much aspirin should I take to prevent a second heart attack?

    Ask your cardiologist: While a daily low-dose aspirin may benefit some people at high risk for a heart attack, including those who've already had one, it isn't advisable or even safe for everyone, such as people over 70 and those with a bleeding disorder. Do not take aspirin without guidance from your healthcare provider.

  • How should I prepare for the possibility of a second heart attack?

    Make sure you're clear about what to do if you suspect you're having another heart attack, such as taking nitroglycerin or chewing an aspirin. Also, make lists of your medications, the names and contact information of your healthcare providers and emergency contacts, and any other medical conditions you have.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Malanchini G, Stefanini G, Panico C et al. 1201Predictors of early recurrent events after acute coronary syndromes: a large-scale analysis based on National Healthcare System administrative dataEur Heart J. 2017;38(suppl_1). doi:10.1093/eurheartj/ehx502.1201

  2. Bentzon JF, Otsuka F, Virmani R, Falk E. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852-66. doi:10.1161/CIRCRESAHA.114.302721

  3. Ittaman SV, Vanwormer JJ, Rezkalla SH. The role of aspirin in the prevention of cardiovascular disease. Clin Med Res. 2014;12(3-4):147-54. doi:10.3121/cmr.2013.1197

  4. American College of Cardiology. Life after a heart attack.

  5. Johns Hopkins Medicine. Is taking aspirin good for your heart?

By Richard N. Fogoros, MD
Richard N. Fogoros, MD, is a retired professor of medicine and board-certified in internal medicine, clinical cardiology, and clinical electrophysiology.