Hepatitis B vs. Hepatitis C: What Are the Differences?

Table of Contents
View All
Table of Contents

A viral hepatitis infection is an inflammation of the liver, resulting in liver damage. There are different types of hepatitis viruses, including hepatitis B (HBV) and hepatitis C (HCV), which are distinct viruses that share some similarities.

Though both viral strains can be transmitted through contact with infected blood, HBV can also be spread through other bodily fluids. Either can cause an acute (short-term) or chronic (long-term) infection, and symptoms can present similarly.

Read on to learn more about the similarities and differences between hepatitis B and C, including causes, symptoms, diagnosis, treatment, and prevention strategies.

patient holding hands in hospital bed

RyanJLane / Getty Images


HBV and HCV have similar symptoms. Acute infections may cause physical symptoms. However, some people may only have mild symptoms while others may be asymptomatic (have no symptoms).

Symptoms of an acute infection may include:

  • Loss of appetite
  • Fatigue
  • Fever
  • Nausea and vomiting
  • Pain in the abdomen and joints
  • Dark-colored urine
  • Light-colored stools (bowel movements)
  • Jaundice

People with chronic HBV and HCV infections often have no symptoms. Some people with chronic infections report vague symptoms such as chronic fatigue and depression.


A viral infection due to HBV or HCV can occur when you come into contact with infected blood. HBV, however, can also be caused by contact with fluids from mucous membranes such as semen and saliva.

If you become infected with either virus, inflammation and significant liver damage can occur. The damage may include cirrhosis (liver scarring) or even liver cancer. It impacts liver functioning, which includes fighting infections, processing nutrients, and removing toxins from the body.

Hepatitis Transmission

HBV and HCV can be transmitted through similar behaviors and activities. However, the prevalence of each virus and how long they take to show symptoms differ.

Hepatitis B

There are a number of ways you may come into contact with HBV-infected blood and bodily fluids, including:

  • Having unprotected sex with someone who has an HBV infection
  • Sharing needles or other items related to injection drug use
  • Coming into contact with an infected person's blood or open wounds
  • Getting accidental needle stick injuries
  • Sharing personal items that have the potential to cause breaks in the skin, such as razors, nail clippers, and toothbrushes

Pregnant people may pass on an HBV infection to their baby as well.

From the time you're exposed to HBV to the time you may experience symptoms (also known as the incubation period) is between 60 days and 150 days. On average, the incubation period is about 90 days.

Prevalence of HBV Infections

In the United States, it's estimated that 850,000 people are living with hepatitis B. However, the numbers may be as high as 2.2 million.

Hepatitis C

The most common ways HCV is transmitted are through injection drug use and pregnancy.

Other possible, though less common, ways HCV may be transmitted include:

  • Tattoo procedures with non-sterile equipment
  • Unintentional needle sticks
  • Using shared personal items that may come into contact with infected blood, such as toothbrushes and razors
  • Undergoing invasive procedures or other injections in a healthcare setting

Transmitting the virus through sex is possible, though it's not common.

Coming into contact with donated blood or having a blood transfusion could possibly transmit HCV. However, the donated blood supply is now routinely tested for HCV, and people who have HBV or HCV infections can't donate blood.

If you do experience symptoms, it can take two to 12 weeks from when you're exposed to HCV to develop.

Prevalence of HCV Infections

About 2.4 million people are estimated to be living with HCV in the United States.

Risk Factors

Many of the factors that increase the likelihood of an HBV and HCV infection are the same, though there are some specific differences.

HBV Risk Factors
  • Being a child born to a pregnant person with HBV

  • Having sex with a partner who has HBV

  • Using injectable drugs

  • Having prolonged contact with people who have chronic HBV

  • Getting accidental needle stick injuries or having contact with infected blood or body fluids (often healthcare workers)

  • Living with a health condition that requires hemodialysis (treatment that filters water and waste from blood)

HCV Risk Factors
  • Being a child born to a pregnant person with HCV

  • Using injectable drugs, even if it was some time ago

  • Getting accidental needle stick injuries or having contact with infected blood

  • Living with a health condition that requires hemodialysis

  • Receiving a blood transfusion or organ transplant before July 1992 (before HCV screenings were available)


Healthcare providers will rely on blood tests to diagnose HBV or HCV infections. They will also ask about your medical history to determine any risk factors and perform a physical examination to look for signs of liver damage.


Treating HBV and HCV infections isn't quite the same. Treatment can depend on whether the infection is acute or chronic, and if tests reveal any liver damage that may have been a result of the infection.

Hepatitis B

Treating HBV is uncommon unless the infection is considered chronic. However, not all chronic HBV infections require treatment.

If tests determine that liver damage has occurred from a chronic infection, treatment will involve antiviral medications. The treatment duration will vary from person to person. Regular monitoring of any liver damage or cancer is common as well.

Hepatitis C

Treatment with antiviral medications can cure acute and chronic HCV infections. Healthcare providers may wait for an acute HCV infection to turn into a chronic one (if it does) before prescribing medication. It is possible for an acute infection to go away on its own.

The length of time you may take the antiviral medications for an HCV infection can be between eight and 24 weeks. A healthcare provider may also recommend getting the hepatitis A and hepatitis B vaccines.


Prevention strategies for HBV and HCV infections are similar. Avoiding contact with any bodily fluids that may transmit the virus is the primary mode of prevention. However, one major difference is that there is a vaccine to prevent HBV, but not HCV.

Hepatitis B

The primary way to prevent a hepatitis B infection is to get the hepatitis B vaccine. Experts recommend getting the vaccine before you may be exposed to the virus, typically as a baby, child, or teenager.

Other ways to prevent an HBV infection include:

  • Not sharing syringes if you use injectable drugs
  • Wearing gloves when in contact with another person's blood or open wounds
  • Using barrier methods during sex, such as condoms
  • Ensuring your tattoo artist uses sterile equipment
  • Not sharing personal items, such as a toothbrush or nail clippers

Hepatitis C

There is no vaccine for HCV. Prevention is associated with avoiding contact with infected blood, including not sharing needles, using sterile tattooing tools, and wearing gloves, which are similar to strategies for preventing an HBV infection.


There are many similarities between HBV and HCV but also some key differences. Both can be transmitted through infected blood. Other bodily fluids, like semen, may also transmit HBV and HCV. Many people with HBV or HCV have no symptoms. Those with symptoms may experience fever, fatigue, loss of appetite, light-colored stools, dark urine, and jaundice.

Blood tests, a physical exam, and a health history are used to diagnose HBV or HCV. HCV is treated with antiviral medication, but some acute infections may resolve on their own. Treatment may not be necessary for acute or chronic HBV infections unless there's liver damage.

Avoiding activities that may expose you to infected blood or bodily fluids can help prevent HBV and HCV. There is also a vaccine for HBV, but not for HCV.

A Word From Verywell

Since HBV and HCV can present similarly, it's encouraged that you speak with a healthcare provider if you suspect an infection. You can discuss behaviors and activities that increase your likelihood of infection, investigate any symptoms, and get the necessary treatment. Making sure you're also up-to-date on your vaccines, including the HBV vaccine, is also a key prevention strategy to keep you healthy.

Frequently Asked Questions

  • Which type of hepatitis is the most severe?

    Having hepatitis B and D infection at the same time (coinfection) is considered the most severe form of chronic viral hepatitis. This coinfection can rapidly lead to hepatocellular carcinoma (a liver cancer) and liver death.

  • Are hepatitis B and C curable?

    Hepatitis C infections can be cured with antiviral medications. While acute hepatitis B infections may go away on their own without treatment, chronic hepatitis B can be treated but not cured.

  • Which type of hepatitis is the most contagious?

    Hepatitis A is considered to be highly contagious. It is spread through contact with infected blood and stool. People with a hepatitis A infection can spread it to someone else before they even begin to feel sick.

13 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Institute of Diabetes and Digestive and Kidney Diseases. What is viral hepatitis?.

  2. Centers for Disease Control and Prevention. Hepatitis C questions and answers for health professionals.

  3. Centers for Disease Control and Prevention. Hepatitis B questions and answers for health professionals.

  4. Centers for Disease Control and Prevention. What is viral hepatitis?.

  5. U.S. Department of Health and Human Services. Viral hepatitis in the united states: data and trends.

  6. American Red Cross. Infectious disease, HLA, and ABO donor qualification testing.

  7. National Institute of Diabetes and Digestive and Kidney Diseases. Hepatitis c.

  8. Centers for Disease Control and Prevention. Hepatitis c.

  9. National Institute for Diabetes and Digestive and Kidney Diseases. Hepatitis b.

  10. World Health Organization. Hepatitis d.

  11. U.S. Food and Drug Administration. Hepatitis c treatments give patients more options.

  12. Centers for Disease Control and Prevention. Hepatitis b questions and answers for the public.

  13. Centers for Disease Control and Prevention. Hepatitis a questions and answers for the public.

By Katie Wilkinson, MPH, MCHES
Katie Wilkinson is a public health professional with more than 10 years of experience supporting the health and well-being of people in the university setting. Her health literacy efforts have spanned many mediums in her professional career: from brochures and handouts to blogs, social media, and web content.