Human Growth Hormone (HGH) and Aging

The human growth hormone (HGH) is a hormone that is made by your body in the pituitary gland and many claim that it has anti-aging properties. It is often marketed as an anti-aging hormone for adults. In children, it is important for normal growth. In adults, HGH helps regulate and maintain your tissues and organs. Children sometimes receive HGH injections because a lack of the hormone in their body is impacting their growth rate.

Older woman checking her face with a hand mirror
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HGH and Aging

Like many hormones, HGH levels decrease as a person gets older. This is a normal part of aging. HGH is becoming a popular anti-aging supplement. Because the hormone is only available in injection form (other forms of HGH have not been proven effective) it must be given by a doctor. The saddest part is that there has been little research on the hormone and aging.

Benefits and Costs

While human growth hormone is not the fountain of youth that people claim, there are some benefits to HGH supplementation. Of course, anyone whose body lacks the ability to make the hormone would benefit from this medical treatment. HGH also increases muscle mass (but not strength). Some people claim to have more energy and feel better on HGH supplementation, but no study has been done to rule out the placebo effect.

Why All the Buzz?

In 1990, an article appeared in the New England Journal of Medicine by Rudman that showed HGH improved the muscle tone and body composition of 12 older men. That tiny piece of research led to an unexpected boom in quacks and “anti-aging” doctors selling HGH-based “Cures for Aging.” Today, there are oral formulas of HGH, injections and even inhaled versions of human growth hormone. Other studies since 1990 have given mixed results. The only firm conclusion is that going to the gym can provide more benefits than HGH (if there are any benefits of HGH at all) with far less cost and risk.

Side Effects

The side effects of HGH are serious. They include diabetes, swelling, high blood pressure, and even heart failure. Inflammation can also occur, causing joint pain and carpal tunnel syndrome.

Bottom Line 

At the moment, there is not enough evidence to recommend HGH as an anti-aging supplement. These risks, dangers, and costs are far too great for anyone to be experimenting with human growth hormone. If you talk with a doctor who recommends HGH for anti-aging, find another doctor. 

4 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Harvard Health. Growth Hormone, Athletic Performance and Aging.

  2. Medeiros A, Siegel watkins E. Live Longer Better: The Historical Roots of Human Growth Hormone as Anti-Aging Medicine. J Hist Med Allied Sci. 2018;73(3):333-359. doi:10.1093/jhmas/jry001

  3. Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med 1990;323:1-6.

  4. Souza FM, Collett-solberg PF. Adverse effects of growth hormone replacement therapy in children. Arq Bras Endocrinol Metabol. 2011;55(8):559-65. doi:10.1590/s0004-27302011000800009

By Mark Stibich, PhD
Mark Stibich, PhD, FIDSA, is a behavior change expert with experience helping individuals make lasting lifestyle improvements.