How Do People Die From Lung Cancer?

"How do people die from lung cancer?" It's a question we really don't want to raise, but, at the same time, it’s an important question for some people for a few reasons. Some of the events that lead to death are unavoidable, such as increasing tumor burden, yet others, such as blood clots or infections are sometimes preventable. Even when not preventable, however, having an idea about what you may expect may help people with lung cancer and their loved ones better prepare for death.

We will look at some of the specific ways that lung cancer can cause death, but first talk about who may wish to (and who may not) look at this information.

Reasons to Ask How Lung Cancer Causes Death

Perhaps the most important reason to ask how lung causes death is that, if we know how death may occur, some lung cancer deaths may be prevented. For example, by knowing that blood clots in the legs (which can break off, causing pulmonary emboli) cause a certain percentage of lung cancer deaths, family members can familiarize themselves with the signs of blood clots and help their loved one seek medical care if the presence of a clot is likely.

Knowing the causes may also help us improve the quality of life for people in the advanced stages of lung cancer. While some of these causes can't be directly treated, the symptoms that result may be lessened by appropriate therapies.

Another reason to discuss what causes death from lung cancer is for the benefit of family members—at least family members who ask the question many of us have when faced with a loved one who has late-stage cancer: "How will he die?" In some cases, the answer to the question may give you some idea on when to call your family to gather near. Family members also frequently fear that their loved one will have a lot of pain. Having some idea what may happen may help you anticipate—and be ready to help—in any way possible.

Before reading on, we are aware of how difficult it can be to read these words if you have a loved one who is nearing death. Even if it’s totally expected, death is never easy. If you are alone, it might be best to wait until you can look at this information with a friend or loved one, who can be a shoulder to lean on. And keep in mind that not everyone wants to know this information. If you do not want to know how a loved one may physically die from lung cancer, please skip this article altogether. It is simply provided here for those people who wish to have some idea of what may occur and may be hesitant to ask their loved one's oncologist. You do not need to know this information to provide the best of care and love to your family member or friend.

Causes of Death From Lung Cancer

There hasn’t been a lot written about the specific causes of death in lung cancer patients, but one study broke down the immediate and contributing causes of death for 100 people. The percentages might vary between studies, but this study does give us an idea of what to expect if a loved one is in the later stages of lung cancer.

Tumor Burden

The presence of tumor was the cause of death in 30% of people with lung cancer, a statistic that was further broken down to 4% of people dying from "tumor load" in the lungs, and 26% due to "tumor load" from metastases. What this means is that the amount of cancer tissue present either in the lungs, or regions that lung cancer spreads too (most often the liver, bones, the brain, and the adrenal glands), led to death.


Infections were responsible for death in 20% of the patients. For 12 of these people, it was pneumonia; for 8, it was sepsis. Sepsis is best described as an overwhelming infection that begins in the bloodstream and spreads through the entire body.

Complications of Metastatic Disease

When lung cancer spreads to other regions of the body, it can interfere with the normal functioning of those organs. For example, if lung cancer has spread to the brain, it may interfere with normal brain functions such as the ability to walk, talk, and swallow, or even result in a hemorrhagic stroke. The spread of lung cancer to the liver can interfere with the liver's ability to do its job of removing toxins from the body, and the buildup of toxins may in turn cause death (this is usually painless, as people slowly become less alert). The spread of lung cancer to the pericardium (the lining surrounding the heart) can result in bleeding between this lining and the heart, resulting in compression of the heart and subsequent death (this is often rapid and painless). These complications were responsible for 18% of deaths.

Pulmonary Hemorrhage

Pulmonary hemorrhage, or bleeding into the lungs, was responsible for 12% of deaths. Even a small amount of bleeding in the lungs (which often results in the symptom of coughing up blood) can be a medical emergency. This is a symptom which many people which to address, as bleeding into the lungs in smaller amounts can result in a feeling of suffocation. When massive bleeding occurs, however, death is usually rapid.

Pulmonary Embolism

Blood clots (deep venous thrombosis) in the legs that break off and travel to the lungs (pulmonary emboli) caused 10% of lung cancer deaths in this study—a significant finding, as blood clots are sometimes preventable, and often treatable.

Blood clots may occur any time after a diagnosis and are sometimes the first symptom of the disease. They are particularly common among people with lung adenocarcinoma.

Looking at the causes of death with lung cancer from a functional standpoint, respiratory failure was the immediate cause of death 38% of the time, whether caused by tumor load, pneumonia or hemorrhage. It’s important to note that most people had more than one mechanism contributing to death.

Other Possible Causes of Death With Lung Cancer

This was just one study. Looking at the causes of death from all types of cancer, other possible causes may include:

  • Complications of treatments such as chemotherapy and radiation therapy A low white blood cell count from chemotherapy, with a resultant overwhelming infection, is not uncommon for those in that later stages of cancer.
  • Medical and medication errors. Unfortunately, hospital errors rank far too high in ultimate causes of death. The risk of these can be minimized by asking a lot of questions, asking further questions if you do not understand something or are uncomfortable with something that is happening, and taking an active role in the care of your loved one.
  • Complications of surgery, such as anesthesia complications and bleeding.
  • Conditions unrelated to cancer, such as heart attacks due to blockages unrelated to cancer.

In asking about the causes of death, what many people fear is that their loved one will suffer as he/she dies. It's important to note that, even though it's common for people to stop eating and drinking near the end of life, the sensation of hunger and thirst also declines. Regarding pain and difficulty with breathing, the majority of people can be kept comfortable under both conditions in the comfort of their own home.

The care and comfort of people who are dying have changed drastically with the use of hospice programs, which can also be a tremendous source of support for the families of those who are dying.

Will Death Be Painful?

One of the biggest fears for those living with cancer and their loved ones is that pain at the end of life will be severe. In fact, in asking these questions, "How will I die,' many people are really asking, "Will dying be painful?" Some people do have severe pain at the end of life while some people have very little pain. The important point is that nobody needs to die in pain. Absolutely nobody should die with uncontrolled pain.

The Dying Process

If you're wondering about how your loved one may die, you may also be wondering what happens in the final stages of lung cancer. This can be a terrifying time, yet at the same time, a beautiful time in many ways. Take a moment to learn about what may happen physically, emotionally, and spiritually.

It's important to note that it's not uncommon for people to know they will die soon, something referred to as nearing death awareness. Your loved one may speak of talking to other loved ones who have died before. While this can be frightening and many people believe their loved one is hallucinating, hospice nurses will tell you that this happens often, and those who are dying may become very agitated and upset if you don't appear to believe them.

Instead of facing this time with fear, families who are aware of this occurrence may take comfort from what hospice nurses experience often. In their book "Final Gifts: Understanding the Special Awareness, Needs, and Communications of the Dying," hospice nurses Maggie Callanan and Patricia Kelley relate the common but misunderstood comments from those who are dying and appear to have one foot in each of two worlds.

Anticipatory Grief

When talking about death, many people experience grief that’s not unlike the grief that occurs after an actual loss (anticipatory grief). Grieving before death is not only normal but may allow families to come together to heal from past hurts and form memories that will never die. You may be coping with feelings of grief even though your loved one is still alive.

A Word From Verywell

Talking about the potential ways that people die from lung cancer can be very painful. If you are coping with a loved one who is facing death, reach out for support. Those who care for people with lung cancer are the unsung heroes and need support as well. Remember to take time to care for and nurture yourself in the journey.

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  1. Schiller, JH, Cipau, A. 100 Questions & Answers about Lung Cancer. Burlington, MA: Jones & Bartlett Learning; 2012.

  2. Nichols L, Saunders R, Knollmann FD. Causes of death of patients with lung cancer. Arch Pathol Lab Med. 2012;136(12):1552-7. doi:10.5858/arpa.2011-0521-OA

  3. Srivastava G, Rana V, Wallace S, et al. Risk of intracranial hemorrhage and cerebrovascular accidents in non-small cell lung cancer brain metastasis patients. J Thorac Oncol. 2009;4(3):333-7. doi:10.1097/JTO.0b013e318194fad4

  4. Depuydt P, Soares M. A bleeding problem in lung cancer patients. Eur Respir J. 2015;45(3):601-3. doi:10.1183/09031936.00199914

  5. Weill Cornell Medicine, Sandra and Edward Myer Cancer Center. Lung cancer: How to protect yourself from blood clots. Updated August 9, 2017.

  6. Peck, DL, Bryant, CD. Encyclopedia of Death and the Human Experience. Newbury Park, CA: SAGE Publishing; 2009.

  7. Medical errors are third cause of deaths in United States. Updated May 26, 2016.

  8. Wong SL, Revels SL, Yin H, et al. Variation in hospital mortality rates with inpatient cancer surgery. Ann Surg. 2015;261(4):632-6. doi:10.1097/SLA.0000000000000690

  9. Hendawi, M. Heart disease as a major cause of death in cancer patients: an epidemiologic analysis of 6 million cancer patients from the United States. Journal of the American College of Cardiology. 2019 March 12 (73)(9): p. 1815. doi:10.1016/S0735-1097(19)32421-0

  10. Cameron, D. Food and fluids in dying patients: some thoughts after the death of a patient. South African Family Practice. 2004:46(4): 6-7. doi:10.1080/20786204.2004.10873064

  11. Callanan, M, Kelley, P. Final Gifts: Understanding the Special Awareness, Needs, and Communications of the Dying. New York, NY: Simon & Schuster; 2012.

  12. Anticipatory grief: preparing for a loved one's end of life. Updated October 12, 2018.

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