How to Give an Intramuscular Injection

Syringe being filled

TEK Image / Science Photo Library / Getty Images

If you have never done it before, the thought of giving an intramuscular (IM) injection can be overwhelming and frightening. However, it's not as difficult as it may seem. If you have ever gotten a flu shot, you know that while it may be uncomfortable to receive an IM shot, it is not painful.

Whether you are giving the shot to yourself or administering it for someone else, doing it for the first time may be a little nerve-wracking. Read through these step-by-step instructions a few times to make yourself familiar and comfortable with the process.

How to Give an Injection

Many medications can only be given with an intramuscular injection. Here's how it's done:

  1. Assemble all the supplies you'll need: the medication to be given, syringe and needle (usually 21g or 22g, and 1 1/2" long), alcohol prep pad, gauze, band-aid.
  2. Wash your hands.
  3. Prepare, or mix the medication according to your instructions and draw the medication into the syringe.
  4. Attach a new needle to the syringe.
  5. You'll be giving this medication in the muscle in the buttock, so have the person lower their pants slightly and lie down on their stomach.
  6. Divide one buttock into quadrants. You will always want to give the injection in the outer, upper quadrant, almost toward the hip.
  7. Select the site: It should be free of scars or bumps.
  8. Clean the site with an alcohol pad and allow it to dry. Do not blow on it or fan the site to quicken the drying process. That just pushes the bacteria back onto the site.
  9. Spread the skin with your fingers and inject the needle straight down in a dart-like motion all the way.
  10. Pull back on the plunger a little. If you see blood enter the syringe, pull the needle out a little and inject the medication. If you do not see blood, simply inject.
  11. Pull the needle out and dispose of properly in a sharps container. Do not put medical or sharp waste in the regular garbage.
  12. Use the gauze to dab up any blood, if necessary, and cover with a bandage.
  13. Wash your hands.

When To Call 911

Intramuscular injections are typically safe, however, allergic reactions may occur. Seek immediate medical help or call 911 if any of the following symptoms occur after getting an injection:

  • rash
  • itchiness
  • difficulty breathing (shortness of breath)
  • swelling of the mouth, lips, or face


  1. Apply ice on the site to numb the area just prior to cleaning it.
  2. Have the patient relax their buttock. Tension in the muscle makes the injection more painful.
  3. Massage the area afterward to enhance the absorption of the medication.
  4. After drawing up the medication, change the needle. The sharper the needle is, the less painful the injection will be.
  5. Hold the syringe by the barrel and not the plunger. Keeping a finger on the plunger may cause you to inadvertently push the plunger before the needle is entirely in the tissue. This can help prevent you from wasting medication.
Was this page helpful?

Article Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. U.S. National Library of Medicine: MedlinePlus. Giving an IM (Intramuscular) Injection.