Human Growth Hormone and Your Cholesterol

Human growth hormone plays many roles in the body, and having a deficiency of it can lead to a high total cholesterol and a higher LDL cholesterol level. Synthetic HGH abuse by athletes without deficiencies may be problematic.

Test tube filled with blood and cholesterol test form document
GIPhotoStock/Getty Images

How Does Human Growth Hormone Affect Cholesterol Levels?

Human growth hormone (HGH or GH) is a chemical produced by the pituitary gland in your brain. HGH stimulates bone growth in childhood, allowing children to grow to a normal adult height. In addition, it helps the body destroy excess lipid molecules and remove them from the bloodstream along with triglycerides.

HGH also plays a role in stimulating protein production, counteracting insulin in the bloodstream and helping the body retain electrolytes, including phosphate, sodium, and water.

HGH Deficiency

Your body produces HGH throughout your life beginning before birth and reaching peak levels around puberty. HGH production gradually declines throughout adulthood. Occasionally the pituitary gland malfunctions and the body doesn't produce enough of this hormone. If this occurs in childhood, normal growth can be affected. In adulthood, the most common effect is altered body composition, with higher amounts of body fat and less lean muscle mass. In adults, the main cause of low HGH levels is a tumor in the pituitary gland. Brain surgery can also disrupt HGH production.

HGH deficiency in adults is exceptionally rare. A 1999 study that focused on HGH deficiency in France concluded that 12 out of every 1 million adults (0.0012%) have this problem. Among children, such deficiencies are more common, but are still quite uncommon, occurring in approximately 2.4 out of 100,000 children (0.0024%).

How Low HGH Affects Cholesterol

In addition to raising levels of fat stored in the body and lowering levels of lean muscle mass, low HGH levels also lead to high total cholesterol, heart disease, low bone density, altered psychological function and a greater risk of dying overall.

In addition to changes in the balance of fat and lean body mass, people with untreated HGH deficiency have higher levels of "bad cholesterol" (LDL) compared with the rest of the population. This form of cholesterol tends to stick to artery walls, forming plaques that produce the type of cardiovascular disease known as atherosclerosis. Atherosclerotic plaques can rupture, triggering blood clots and potentially blocking blood flow to the heart or brain, which cause a heart attack or stroke.

Effects of HGH Injections on Cholesterol

HGH can be replaced with injections of a synthetic growth hormone known as recombinant human growth hormone (rHGH). These injections have been found to stimulate growth in children, increase lean muscle mass in both children and adults, and improve the other factors affected by low levels of HGH.

Because of its ability to boost muscle mass, rHGH has sometimes been abused by athletes and others seeking to change their physical appearance and enhance athletic performance. Unfortunately, since this sort of use tends to be secretive, physicians and scientists don't have much information about the positive or negative effects, including the impact on cholesterol and cardiovascular risk of rHGH use by individuals who have normal levels of HGH.

Research on the impact of rHGH on cholesterol has been mixed. Some studies have found that the synthetic hormone doesn't change cholesterol levels, whereas others have shown a drop in "bad cholesterol" levels. One study demonstrated a drop in both "bad cholesterol" and total cholesterol levels during the first 3 months, but thereafter despite continued use of rHGH participants' cholesterol levels returned more or less to where they had been before starting the hormone injections.

Other studies have reported negative consequences of rHGH use, including higher levels of lipoprotein(a). As with "bad cholesterol," higher levels of lipoprotein(a) contribute to atherosclerotic plaques in artery walls. However, research also suggests that rHGH lowers blood levels of C-reactive protein (CRP), and reduced CRP levels are seen as a sign of decreased risk for heart problems.

People who take rHGH should only do so as prescribed by their doctor or nurse practitioner. They should also be sure to keep track of their cholesterol levels because low HGH levels can significantly increase cholesterol levels. Some people taking rHGH may also need a cholesterol-lowering medication, such as a statin, to bring down cholesterol levels and reduce the risk of having a heart attack or stroke.

Those using rHGH without the advice of a licensed healthcare provider should be aware that this hormone can have significant (and potentially harmful) effects on cholesterol levels and heart health. Although rHGH treatment can benefit people who have low natural levels of HGH, experts don't know the cardiovascular effects or other ramifications of rHGH use in those with normal HGH levels.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  • Melmat, Shlomo. "Physiology of Growth Hormone." 2015.

  • Rogol, Alan D. "Treatment of Growth Hormone Deficiency in Children." June, 2015.

  • Snyder, Peter J. "Growth Hormone Deficiency in Adults." 2015.

  • Snyder, Peter J. "Use of Androgens and Other Drugs by Athletes." 2016.

  • Bates, A.S., et al. "The Effect of Hypopituitarism on Life Expectancy." Journal of Clinical Endocrinology and Metabolism 81 (1996):1169-72.
  • Baum, H.B., et al. "Effects of Physiologic Growth Hormone Therapy on Bone Density and Body Composition in Patients With Adult-Onset Growth Hormone Deficiency: A Randomized, Placebo-Controlled Trial." Annals of Internal Medicine 125 (1996):883-90.
  • Bengtsson, B.A., et al. "Treatment of Adults with Growth Hormone (GH) Deficiency With Recombinant Human GH." Journal of Clinical Endocrinology and Metabolism 76 (1993):309-17.
  • Biller, B.M., et al. "Withdrawal of Long-Term Physiological Growth Hormone (GH) Administration: Differential Effects on Bone Density and Body Composition in Men With Adult-Onset GH Deficiency." Journal of Clinical Endocrinology and Metabolism 85 (2000):970-6.
  • Carroll, P.V., et al. "Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review." Journal of Clinical Endocrinology and Metabolism 83 (1998):382-95.
  • Koranyi, J., et al. "Baseline Characteristics and the Effects of Five Years of GH Replacement Therapy in Adults With GH Deficiency of Childhood or Adulthood Onset: A Comparative, Prospective Study." Journal of Clinical Endocrinology and Metabolism 86 (2001): 4693-9.
  • Sassolas, G., et al. "GH Deficiency in Adults: An Epidemiological Approach." European Journal of Endocrinology 141 (1999):595-600.
  • Sesmilo, G., et al. "Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men With Growth Hormone Deficiency: A Randomized, Controlled Clinical Trial." Annals of Internal Medicine 133(2000):111-22.
  • Stochholm, K., et al. "Incidence of GH Deficiency - A Nationwide Study." European Journal of Endocrinology 155 (2006):61-71.

By Heather M. Ross
Heather M. Ross, PhD, DNP, FAANP is a nurse practitioner and PhD in Human and Social Dimensions of Science and Technology.