IBD and the Menstrual Cycle

Having Crohn's disease or ulcerative colitis may have an effect on menstruation

Inflammatory bowel disease (IBD) affects the whole person. This means that people who live with Crohn’s disease, ulcerative colitis, or indeterminate colitis may also experience a variety of health issues that take place outside the digestive system. For people who menstruate, they may find that their IBD symptoms change during their period.

It may also be that your period may change as a result of how active IBD is at that time (how much inflammation is occurring). Anecdotally, patients will discuss having an uptick of symptoms during their period, or right before.

However, there has not been a lot of research into how having a period intersects with IBD. This article will discuss the menstrual cycle and IBD and how they may affect one another.

A calendar for tracking periods with a tampon and birth control pills.
Carol Yepes / Getty Images

Why Periods Are Important In IBD

IBD tends to be a disease of young people, with most affected individuals being diagnosed between the ages of 15 and 35 (a second, smaller group are diagnosed later in life). This means that many women may be diagnosed around the time of their first menstrual period or soon after.

This brings up questions about what’s considered “normal” for a menstrual cycle, because it is not one set of criteria—it is a range of them. Further, there may be confusion as to whether having IBD, or having active IBD, may affect periods. 

The menstrual cycle may change over time as well as in response to health conditions. As a result, it can be used as one measure of the overall health of a menstruating person.

In fact, in their committee opinion, the American College of Obstetricians and Gynecologists called the menstrual cycle a “vital sign” for girls and adolescents. They urge physicians to help educate young menstruators and their caregivers about what’s considered “normal” for a period.

Being able to determine when the pattern of one’s period is out of that normal range may help in identifying health problems.

Periods Before an IBD Diagnosis

Changes in the menstrual cycle may happen before IBD is diagnosed. One study showed that women often found that their monthly cycle had changed in some way in the year prior to being diagnosed with ulcerative colitis or Crohn’s disease.

Of the 121 women included in the research, 25% said the timing of their cycle had changed (further apart, closer together, or becoming irregular). There were 21% who said that the flow during their period changed in some way, either becoming heavier, lighter, or irregular.

Among the 40% (48 women) who had pain with their period (also called dysmenorrhea), 33% (16 women) found that their pain had increased in the year before diagnosis. However, the majority of women included in the study reported no change in their cycle.

The researchers don’t know why some people have these changes in their period and some don’t. Still, enough women experience differences that period changes are important to keep track of in IBD: discuss them with your doctor if necessary.

Periods After an IBD Diagnosis

There is some good news for the relationship between IBD and the menstrual cycle. After the first year of diagnosis, for most people, periods tended to revert to their regular pattern. This means that, for any one particular person, their periods had about the same pattern of cycle and flow length in the years following an IBD diagnosis.

The researchers thought that perhaps, around the time of an IBD diagnosis, there is additional stress on the body that could affect a monthly cycle. That might explain why some women have changes in their cycle in the year before a diagnosis and for a time afterward.

Having a regular period is important, especially in the setting of fertility. Women with IBD are shown to have about the same risk of infertility as women who don’t have IBD.  However, there is a persistent misconception that IBD, and especially Crohn’s disease, may lead to a greater risk of infertility.

The study showing that most people with IBD have regular periods may be a reason to think factors that influence fertility might not be affected. Indeed, other studies have shown IBD doesn’t usually have a major effect on fertility.

It also means that interventions for infertility (such as in-vitro fertilization, or IVF) may have the same chances for success in women with IBD.

IBD Medications and Menstruation

Researchers in one study found that when women were taking steroid medications, there was an increased risk of having an irregular cycle. However, those who were taking either a thiopurine (such as azathioprine or mercaptopurine) or an anti-TNF medication (such as Cimzia, Humira, Remicade, or Simponi) along with a steroid did not have the same risk.

This led the authors of the study to say that having a regular cycle is another reason IBD patients should have long-term therapy that helps them discontinue steroids.

Another study of 139 patients (72% with Crohn’s disease and 28% with ulcerative colitis) from Israel found that women receiving biologic medications experienced more of certain symptoms both before and during their period. Before their period, women reported irritability, nervousness, leg swelling, pelvic pain, and fatigue.

During their period, women reported pelvic pain, lower back pain, abdominal pain, and fatigue. These signs and symptoms were at higher levels in women taking biologics than in those who were not receiving this type of drug.

IBD and Irregular Periods

An irregular period is when the timing of the menstrual cycle is out of what is considered the normal range of variation. That could mean having periods that are sometimes closer together or sometimes further apart. One measurement that is used to define “irregular” is if the time between periods varies by more than 20 days from month to month.

Irregular periods are a reason to see a healthcare professional. The three times when an irregular period may be on the spectrum of “normal” are in the first year or two after menstruation starts, when entering perimenopause (the time leading up to the end of menstruation), or after a miscarriage, pregnancy termination, or giving birth.

In one study of 121 women, researchers used a type of survey called the Inflammatory Bowel Disease Questionnaire (IBDQ) to understand how their periods affected them. The IBDQ is often used in clinical studies and helps researechers to understand how IBD is affecting quality of life.

The researchers found a connection between IBDQ scores and more irregular cycles. Those people who said their menstrual cycle was “fairly regular” had lower IBDQ scores than those who said their cycle was “regular.” People who said their cycles were “irregular” also had lower IBDQ scores when compared to those who said their cycle was “fairly regular.”

Is It IBD or Is It My Period?

Some women, both those who are healthy and those who live with IBD, find they have gastrointestinal symptoms around the time of their period. This can include symptoms like nausea, vomiting, or lack of appetite.

Other symptoms that occur with IBD that might also happen at certain times in a woman’s cycle include trouble sleeping, depression, feeling irritable, and aches and pains. For this reason, it may be challenging to figure out when signs and symptoms arise from IBD as opposed to those that are associated with a menstrual period.

However, it’s important to know if any symptoms in the digestive system are related to menstruation and not IBD. This is in order to avoid a change in medications when it’s not truly needed, if it turns out that symptoms are not being caused by the IBD.

One study of 47 women with IBD and 44 healthy controls found that those with IBD had symptoms more often during their menstrual cycle. Some of the more common signs and symptoms included abdominal pain, nausea, and gas. However, the researchers note that IBD symptoms did not change much during this time.

Another study compared symptoms during menstruation. It compared 139 women with IBD and 258 healthy women. The researchers noted a number of symptoms, including irritability, nervousness, restlessness, headache, anxiety, nausea, vomiting, leg swelling, low back pain, constipation, excessive urination, abdominal pain, and fatigue were “significantly” more common in women with IBD.

Why Charting Periods May Help

People who menstruate are often asked by healthcare professionals about when they had their last period. Making a note of when a period starts, how many pads/tampons are needed each day, and how many days it lasts is helpful for your doctor to know when evaluating your IBD and menstural symptoms.

Keeping track of symptoms is also worthwhile. This can be done in a variety of ways, using anything from a paper calendar to apps that help track periods

A menstrual cycle is charted by keeping track of its length in days. The days that are counted should be from the first day of period bleeding to the next first day of period bleeding. This is the cycle length.

Tracking your cycle will help you keep on top of any patterns that develop. Are periods happening on a regular schedule? Is the amount of flow pretty much the same from period to period? Are there persistent symptoms like cramps, nausea, mood alterations, or problems sleeping?

It may also make sense to keep track of these symptoms alongside those that are associated with IBD. This could help in understanding if, for instance, a symptom like diarrhea happens more frequently during certain days of your menstrual cycle.

Treating Period Symptoms 

Some people who menstruate treat pain related to their cycle with non-steroidal anti-inflammatory drugs (NSAIDs). This includes common over-the-counter drugs such as aspirin and ibuprofen.

However, gastroenterologists often tell their patients with IBD to avoid these medications. This is because some research has shown that the frequent use of NSAIDs could be associated with an increase in IBD inflammation.

At least one study has shown that low doses might not have an effect on IBD. However, using NSAIDs more than five times a month was associated with active symptoms in Crohn’s disease. It’s important that people who live with IBD discuss the use of NSAIDs to treat pain in order to understand the risk.

When to Talk to a Doctor

For people who live with IBD, it can be difficult to know which physician to talk to about extra-intestinal problems. For questions about the menstrual cycle, an obstetrician-gynecologist may be the best person to provide answers.

However, it is important to also keep your IBD team (such as the gastroenterologist or IBD nurse) updated about issues with menstruation and gynecological health. It can also help to ask that your IBD team communicate with your OB-GYN.

This is especially true if there are issues with the menstrual cycle that may affect overall health. For instance, if periods are very heavy, and there is also bleeding because of active IBD, there could be an increased risk of anemia. 

Some of the reasons to seek out help from an OB-GYN about menstruation include when:

  • Periods haven’t started within three years after breast development starts
  • Periods haven’t started started by age 14 in girls who have excessive body hair growth (hirsutism), have a history of an eating disorder, or who may be over-exercising
  • Periods haven’t started by the age of 15
  • Periods are closer together than every 21 days
  • Periods are further apart than every 45 days
  • There are 90 days or more between periods (even one time)
  • A period lasts for more than seven days
  • A period is so heavy that pads or tampons need to be changed every one to two hours
  • Periods are heavy, and there’s also a history of a bleeding disorder (either personally or in the family) or excessive bruising or bleeding

For those who may want to become pregnant, it’s also going to be important to start that conversation early. Understanding the menstrual cycle and how it may or may not affect IBD will be part of planning conception and pregnancy.

A Word From Verywell

There hasn't been a significant amount of research done on the intersection of IBD and the menstrual cycle. Furthermore, the studies that have been performed have some drawbacks.

One problem is that minority populations are not included in significant-enough numbers in these studies. This means that White women are over-represented and women of Black, Hispanic, Asian, Native American, and other backgrounds are under-represented.

Another is that some studies may include more women who are older. That brings a concern that some of the research may include too many women who may be experiencing changes in their menstrual cycle because of perimenopause.

People who menstruate may notice that they experience diarrhea or other symptoms before or during their period, but may not connect it to IBD or mention it to a gastroenterologist or an OB-GYN. It’s worth discussing these changes with your healthcare team in order to keep track of any changes that may happen over time.

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  1. Crohn’s and Colitis Foundation. The facts about inflammatory bowel diseases. November 2014.

  2. ACOG Committee Opinion No. 651: Menstruation in girls and adolescents: using the menstrual cycle as a vital signObstet Gynecol. 2015;126:e143-e146. doi:10.1097/AOG.0000000000001215

  3. Saha S, Zhao YQ, Shah SA, et al. Menstrual cycle changes in women with inflammatory bowel disease: a study from the ocean state Crohn's and colitis area registry. Inflamm Bowel Dis. 2014;20:534-540. doi:10.1097/01.MIB.0000441347.94451.cf 

  4. Tavernier N, Fumery M, Peyrin-Biroulet L, Colombel JF, Gower-Rousseau C. Systematic review: fertility in non-surgically treated inflammatory bowel diseaseAliment Pharmacol Ther. 2013;38:847-853. doi:10.1111/apt.12478

  5. Lahat A, Falach-Malik A, Haj O, Shatz Z, Ben-Horin S. Change in bowel habits during menstruation: are IBD patients different? Therap Adv Gastroenterol. 2020;13:1756284820929806. doi:10.1177/1756284820929806

  6. Munro MG, Critchley HO, Fraser IS. The FIGO systems for nomenclature and classification of causes of abnormal uterine bleeding in the reproductive years: who needs them? Am J Obstet Gynecol. 2012;207:259-265. doi:10.1016/j.ajog.2012.01.046 

  7. Lim SM, Nam CM, Kim YN, et al. The effect of the menstrual cycle on inflammatory bowel disease: a prospective study. Gut Liver. 2013;7:51-57. doi:10.5009/gnl.2013.7.1.51

  8. Long MD, Kappelman MD, Martin CF, Chen W, Anton K, Sandler RS. Role of nonsteroidal anti-Inflammatory drugs in exacerbations of inflammatory bowel disease. J Clin Gastroenterol. 2016;50:152-156. doi:10.1097/MCG.0000000000000421