Digestive Health Irritable Bowel Syndrome Related Conditions IBS and Other Overlapping Health Problems By Barbara Bolen, PhD Barbara Bolen, PhD Twitter Barbara Bolen, PhD, is a licensed clinical psychologist and health coach. She has written multiple books focused on living with irritable bowel syndrome. Learn about our editorial process Updated on March 04, 2021 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Robert Burakoff, MD, MPH Medically reviewed by Robert Burakoff, MD, MPH LinkedIn Robert Burakoff, MD, MPH, is board-certified in gastroentrology. He is the vice chair for ambulatory services for the department of medicine at Weill Cornell Medical College in New York, where he is also a professor. He was the founding editor and co-editor in chief of Inflammatory Bowel Diseases. Learn about our Medical Expert Board Print Following the old chestnut "when it rains it pours," patients with Irritable Bowel Syndrome (IBS) often find themselves dealing with other health problems in addition to their IBS. Medical professionals call these parallel conditions "comorbid disorders." As researchers continue in their quest for a better understanding of the underlying causes of IBS, an active area of inquiry focuses on the tendency of patients with IBS to experience extra-intestinal symptoms and illnesses at a higher rate than normal. Here is an overview of what is known so far about IBS and its relationship with other health problems. As you read this, please keep in mind that this tendency toward parallel conditions is not seen in every person with IBS. BSIP/UIG / Getty Images Common Comorbid GI Illnesses Although it is a lousy experience for the patient, it doesn't seem so surprising that an IBS patient would also experience a co-existing gastrointestinal disorder. It may well be that a shared factor is underlying each disorder. Here are some GI illnesses that have been shown to occur at a higher rate in IBS patients than in non-IBS patients (click on each link to get more information): Diverticulitis Dysphagia (difficulty with swallowing) Esophageal Spasm Fecal incontinence Gastroesophageal reflux disease (GERD) Peptic ulcer disease and functional dyspepsia (symptoms with no identified ulcer) Common Non-GI Related Comorbid Disorders More perplexing is the fact that IBS patients are more likely to experience non-gastrointestinal disorders than would normally be expected. Intuitively, it is harder to grasp why this would be the case. Chronic fatigue syndrome Chronic prostatitis (chronic pelvic pain syndrome) Dysmenorrhea (severe menstrual pain) Interstitial cystitis Fibromyalgia Migraine headaches Temporomandibular joint (TMJ) disorders Comorbid Psychiatric Illnesses A higher rate of psychiatric illness in IBS patients is a well-established fact. Unfortunately, this information has often been distorted such that IBS patients are told that their digestive problems are all psychological. It is fair to say that there may be underlying factors that contribute to the onset and maintenance of both IBS and any co-existing mental health difficulties. Here are some of the psychiatric disorders that are seen alongside IBS: Anxiety Panic disorder Obsessive-Compulsive Disorder (OCD) Depression Why There Is a Higher Rate of Comorbid Illness As of now, there are no clear-cut reasons to explain the phenomenon of comorbid illness and IBS. The puzzle is confounded by the fact that not all IBS patients experience a co-existing disorder. In fact, although overall there is an increased risk of comorbid illness in IBS patients, comorbid illness still affects less than 20% of IBS sufferers. In some cases, shared explanations could perhaps be identified as the culprit. This possibility is more likely when the comorbid disorder shares similar features, such as a possible overall problem with digestive motility. Similarly, the link with psychiatric illness could be explained by a shared imbalance of certain neurotransmitters within the central nervous system. Another possible explanation is that some IBS patients have a tendency to be hyper-aware of physical sensations and symptoms. This excessive attention leads them to be more likely to seek medical advice about their symptoms and thus the greater rates of illness diagnoses. Evidence for this theory comes from the fact that for some disorders there are no shared biological factors that could explain the various illnesses. Like the chicken-and-the-egg, it is unclear whether this hypersensitivity contributes to their IBS, or if experiencing IBS lends one to be more aware of bodily sensations. Modern science is sure to come up with better answers. One newer area of inquiry is a look at a pathway in the body known as the hypothalamic-pituitary-adrenal axis. This pathway affects many of our bodily systems and appears to be related to how our bodies deal with stress. It has been theorized that a dysfunction in this pathway sets the stage for increased inflammation which contributes to these comorbid problems. What This Means for You If you find yourself in the unenviable position of dealing with other health problems in addition to your IBS, talk with your doctor about the possibility of common causal factors. This information may then aid in the development of a shared plan for symptom management. You may find that a whole body approach is more helpful than treatments that target specific symptoms. Options for improving your overall health include improved nutrition, the use of herbal remedies, and engaging in the process of psychotherapy. Was this page helpful? Thanks for your feedback! One of the most challenging aspects of having IBS is trying to figure out what's safe to eat. Our recipe guide makes it easier. Sign up and get yours now! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 9 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Chey WD, Kurlander J, Eswaran S. 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The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations. J Mol Psychiatry. 2014;2(1):4. doi:10.1186/2049-9256-2-4 Turna J, Grosman Kaplan K, Patterson B, et al. Higher prevalence of irritable bowel syndrome and greater gastrointestinal symptoms in obsessive-compulsive disorder. Journal of Psychiatric Research. 2019;118:1-6. doi:10.1016/j.jpsychires.2019.08.004 Longarzo M, Quarantelli M, Aiello M, et al. The influence of interoceptive awareness on functional connectivity in patients with irritable bowel syndrome. Brain Imaging and Behavior. 2017;11(4):1117-1128. doi:10.1007/s11682-016-9595-5 Kano M, Muratsubaki T, Van Oudenhove L, et al. Altered brain and gut responses to corticotropin-releasing hormone (Crh) in patients with irritable bowel syndrome. Sci Rep. 2017;7(1):12425. doi:10.1038/s41598-017-09635-x Additional Reading American Gastroenterological Association. Irritable bowel syndrome. International Foundation of Gastrointestinal Disorders. About irritable bowel syndrome.