Hepatitis The Immune System and Its Role in Hepatitis By Charles Daniel Charles Daniel Charles Daniel, MPH, CHES is an infectious disease epidemiologist, specializing in hepatitis. Learn about our editorial process Updated on February 23, 2022 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Jay N. Yepuri, MD, MS Medically reviewed by Jay N. Yepuri, MD, MS Facebook LinkedIn Twitter Jay Yepuri, MD, MS, is a board-certified gastroenterologist and a practicing partner at Digestive Health Associates of Texas (DHAT). Learn about our Medical Expert Board Fact checked Verywell Health content is rigorously reviewed by a team of qualified and experienced fact checkers. Fact checkers review articles for factual accuracy, relevance, and timeliness. We rely on the most current and reputable sources, which are cited in the text and listed at the bottom of each article. Content is fact checked after it has been edited and before publication. Learn more. by Nick Blackmer Fact checked by Nick Blackmer LinkedIn Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years’ experience in consumer-oriented health and wellness content. Learn about our editorial process Print The immune system is a collection of organs, cells, and tissues that work together to protect your body from pathogens (such as bacteria, viruses, parasites, and fungi) that can cause disease. It’s a very complex defense system that not only helps your body respond to infectious diseases (sometimes with help from immunizations), but it can also cause trouble in the form of allergies and autoimmune diseases. Autoimmune diseases are the result of a process in which the immune system mistakes an organ or body system for an invader, and attacks it as such. This results in inflammation and damage to the organ. Justin Sullivan / Staff / Getty Images Autoimmune Hepatitis The immune system is involved in one way or another in patients with many types of hepatitis, which is an inflammation of the liver. For people with chronic viral hepatitis, the immune system attacks the virus and the resulting long-term inflammation can cause damage to the liver. Autoimmune hepatitis, when the body’s immune system mistakes normal liver tissue for an invader and attacks accordingly, is a chronic disease that causes inflammation and liver damage. If left untreated, autoimmune hepatitis can worsen over time and lead to cirrhosis and liver failure. The disease can cause symptoms that resemble those of viral or other types of hepatitis such as: Fatigue Joint pain Nausea Loss of appetite Pain or discomfort over the liver Skin rashes Dark yellow urine Light-colored stools Jaundice, or yellowing of the skin and whites of the eyes Vaccines There are currently two vaccines to prevent against two different types of viral hepatitis—hepatitis A and hepatitis B. Vaccines, or immunizations, use a trigger (such as inactivated or weakened viral material) to create an immune response against the invader. The immune system then essentially has a developed and effective response available when a true pathogen becomes a threat. Treatments For patients with autoimmune hepatitis, the goal of treatment is to prevent liver damage that occurs as a result of the immune system’s assault on the liver. One way modern medicine is able to achieve this goal is by using treatments, such as steroids or steroids plus azathioprine, that suppress the immune system to help prevent further damage. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 2 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. National Institute of Diabetes and Digestive and Kidney Diseases. Symptoms & causes of autoimmune hepatitis. Mack CL, Adams D, Assis DN, et al. Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases. Hepatology. 2020;72(2):671-722. doi:10.1002/hep.31065